rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2007-1-66-77rmt-1089Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSЛёгочный сурфактант и его применение при заболеваниях лёгкихLung Surfactant and Its Use in Lung DiseasesРозенбергО. А.RosenbergO. A.Отдел медицинской биотехнологии Центрального научно-исследовательского рентгенорадиологического института Минздрава РФ, Санкт-ПетербургDepartment of Medical Biotechnology, Central Research Institute of Roentgenology and Radiology, Ministry of Health of the Russian Federation, Saint Petersburg20072002200731Том III № 1 2007 г.6677Copyright © Розенберг О.А., 20072007Розенберг О.А.Rosenberg O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1089

В обзоре рассмотрены современные представления о функциях легочного сурфактанта (ЛС), сделан акцент на защитных и барьерных свойствах, а также свойствах поддержания врожденного локального и адаптивного иммунитета. Проведен анализ состава коммерческих препаратов ЛС, представлены сведения о качественных и количественных нарушениях ЛС при различных видах патологии новорожденных и взрослых. Проведен детальный анализ результатов клинических испытаний различных препаратов ЛС при лечении ОРДС у взрослых. Представлены новые сведения о результатах и перспективах сурфактант-терапии бронхиальной астмы, ХОБЛ и туберкулеза легких.

 

The review considers the present views of lung surfactant (LS) functions with emphasis on its protective and barrier properties and ability to maintain local and adaptive immunity. The composition of commercial LS formulations is analyzed. Data on qualitative and quantitative LS abnormalities are presented in various diseases in neonates and adults. The results of clinical trials of different LS formulations in the treatment of acute respiratory distress syndrome in adults are analyzed in detail. Recent data on the results of and prospects for surfactant therapy for bronchial asthma, chronic obstructive pulmonary disease and pulmonary tuberculosis are given.

 

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The authors declare that there are no conflicts of interest present.