rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2006-2-14-19rmt-1167Research ArticleНАРУШЕНИЯ ГЕМОДИНАМИКИHEMODYNAMIC DISORDERSГемодинамика и газообменные эффекты ингаляционного оксида азота при ОРДС у кардиохирургических больныхHemodynamics and Gas Exchange Effects of Inhaled Nitrous Oxide in Patients with Acute Respiratory Distress SyndromeПопцовВ. Н.PoptsovV. N.ФГУ НИИ Трансплантологии и искусственных органов РОСЗДРАВАResearch Institute of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation20062004200622Том II № 2 2006 г.1419Copyright © Попцов В.Н., 20062006Попцов В.Н.Poptsov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1167

В последнее десятилетие в зарубежной клинической практике при лечении острого респираторного дистресс-синдрома (ОРДС) стала применяться терапия ингаляционным оксидом азота иNO), направленная на улучшение оксиге-нирующей функции лёгких и снижение напряженности ИВЛ. Целью исследования явилась оценка гемодинамических и газообменных эффектов иNO при ОРДС, развившемся после кардиохирургических операций. Обследовали 58 больных (43 мужчин и 15 женщин) в возрасте от 21 до 76 (55,2±2,4) лет. Исследование продемонстрировало, что в 48,3% наблюдений начальная стадия ОРДС сопровождается повышением тонуса лёгочных сосудов, обусловленных нарушением NO-зависимой вазодилатации. У этих больных иNO-терапия является эффективным лечебным методом коррекции расстройств гемодинамики и оксигенирующей функции лёгких.

Inhaled nitrous oxide (iNO) therapy aimed at improving pulmonary oxygenizing function and at decreasing artificial ventilation (AV) load has been used in foreign clinical practice in the past decade. The study was undertaken to evaluate the hemodynamic and gas exchange effects of iNO in acute respiratory distress syndrome (ARDS) that developed after car-diosurgical operations. Fifty-eight (43 males and 15 females) patients aged 21 to 76 (55.2±2.4) years were examined. The study has demonstrated that in 48.3% of cases, the early stage of ARDS is attended by the increased tone pulmonary vessels due to impaired NO-dependent vasodilatation. In these patients, iNO therapy is an effective therapeutic method for correcting hemodynamic disorders and lung oxygenizing function.

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The authors declare that there are no conflicts of interest present.