rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2014-1-58-67rmt-1334Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНА OPRM1 118A/G НА ПЕРЦЕПЦИЮ БОЛИ И ФАРМАКОДИНАМИКУ НАРКОТИЧЕСКИХ АНАЛГЕТИКОВThe Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic AnalgesicsЖенилоВ. М.ZheniloV. M.МахаринО. А.MakharinO. A.olegmaharin@yandex.ruРостовский государственный медицинский университет, кафедра фармакологии и клинической фармакологии, РостовнаДонуРоссияDepartment of Pharmacology and Clinical Pharmacology, Rostov State Medical University, RostovonDonRussian Federation2014150620141015867Copyright © Женило В.М., Махарин О.А., 20142014Женило В.М., Махарин О.А.Zhenilo V.M., Makharin O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1334

Полиморфизм μ-опиоидного рецептора является одним из наиболее изученных полиморфизмов, влияющих на активность наркотических аналгетиков. Несмотря на большое количество публикаций, посвященных данной проблеме, полученные результаты в настоящее время не применяются в клинической практике. Целью данного обзора является описание влияний данного полиморфизма на восприятие болевого стимула и чувствительности к наркотическим аналгетикам. Показано, что носители генотипа 118G/G μ-опиоидного рецептора толерантны к действию наркотических аналгетиков и для достижения желаемого эффекта им требуется большая доза по сравнению с носителями нормального генотипа. При этом вероятность возникновения побочных эффектов, связанных с назначением наркотических аналгетиков, существенно не отличается между носителями мажорного генотипа и носителями генотипов 118A/G, 118G/G. 

The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently used in clinical practice. The purpose of this review is to describe the impact of this polymorphism on the perception of pain and sensitivity to narcotic analgesics. It is shown that patients with the G118G genotype of μ-opioid receptor are tolerant to narcotic analgesics and need a larger dose to achieve the desired effect than that in normal genotype. At the same time, the likelihood of side effects associated with the use of narcotic analgesics does not significantly differ between the carriers of normal genotype and those of the A118G, G118G genotypes.

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The authors declare that there are no conflicts of interest present.