References

rmt

Общая реаниматология

General Reanimatology

1813-97792411-7110

FSBI "SRIGR" RAMS

10.15360/1813-9779-2006-6-15-25

rmt-1355

Research Article

РЕДАКЦИОННАЯ СТАТЬЯ

EDITORIAL

The Safar Center for Resuscitation Research: Searching for Breakthroughs in the New Millennium

Kochanek

P. M.

Kochanek

P. M.

Bayir

Berger

R. P.

Berger

R. P.

Dixon

C. E.

Dixon

C. E.

Jenkins

Kline

A. E.

Kline

A. E.

Tisherman

Wagner

A. K.

Wagner

A. K.

Clark

R. S.B.

Clark

R. S.B.

Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USADepartment of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA

Department of Pediatrics Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, USADepartment of Pediatrics Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, USA

Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USADepartment of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA

Departments of Surgery and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USADepartments of Surgery and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA

2006

20122006

Том II № 5-6 2006 г.

1525

2006

Kochanek P.M., Bayir H., Berger R.P., Dixon C.E., Jenkins L., Kline A.E., Tisherman S., Wagner A.K., Clark R.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.reanimatology.com/rmt/article/view/1355

This review, written on the occasion of the 70 th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the University of Pittsburgh School of Medicine. Current and recent studies describing bench to bedside investigation in the areas of traumatic brain injury (TBI), cardiopulmonary arrest, hemorrhagic shock, and ultranovel approaches to resuscitation are discussed. Investigation in TBI across a variety of topics by many investigators including mechanism of neuronal death, oxidative and nitrative stress, proteomics, adenosine, serotonin, novel magnetic resonance imaging application, inflicted childhood neurotrauma, and TBI rehabilitation is addressed. Research discussed in the program of cardiopulmonary arrest includes optimization of the use of mild hypothermia and novel investigation in experimental asphyxial cardiac arrest. In the program on hemorrhagic shock, our recent work on the application of mild hypothermia to prolong the «golden hour» is presented. Finally, a brief overview of our studies of a novel approach to the resuscitation of exsanguination cardiac arrest using emergency preservation for resuscitation (EPR) is provided.

This review, written on the occasion of the 70th anniversary of the Institute for General Reanimatology of the Russian Academy of Medical Sciences, provides an update of recent research in the field of resuscitation medicine carried out at the Safar Center for Resuscitation Research at the University of Pittsburgh School of Medicine. Current and recent studies describing bench to bedside investigation in the areas of traumatic brain injury (TBI), cardiopulmonary arrest, hemorrhagic shock, and ultra-novel approaches to resuscitation are discussed. Investigation in TBI across a variety of topics by many investigators including mechanism of neuronal death, oxidative and nitrative stress, proteomics, adenosine, serotonin, novel magnetic resonance imaging application, inflicted childhood neurotrauma, and TBI rehabilitation is addressed. Research discussed in the program of cardiopulmonary arrest includes optimization of the use of mild hypothermia and novel investigation in experimental asphyxial cardiac arrest. In the program on hemorrhagic shock, our recent work on the application of mild hypothermia to prolong the «golden hour» is presented. Finally, a brief overview of our studies of a novel approach to the resuscitation of exsan-guination cardiac arrest using emergency preservation for resuscitation (EPR) is provided.

Traumatic Brain InjuryResuscitationChild AbuseInflicted Childhood NeurotraumaHemorrhagic ShockEmergency Preservation and ResuscitationApoptosisAdenosineProteomics

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The authors declare that there are no conflicts of interest present.