rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2006-6-184-190rmt-1383Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSАпоптоз при критических состоянияхApoptosis in Critical ConditionsГолубевА. М.GolubevA. M.МоскалеваЕ. Ю.MoskalevaE. Yu.СеверинС. Е.SeverinS. E.ВеснянкоТ. П.VesnyankoT. P.КузовлевА. Н.KouzovlevA. N.АлкадарскийА. С.AlkadarskyA. S.ПорошенкоГ. Г.PoroshenkoG. G.ГУ НИИ общей реаниматологии РАМН, МоскваResearch Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowГУЗ Московский НИИ медицинской экологии Департамента здравоохранения, МоскваMoscow Research Institute of Medical Ecology, Department of Public Health, MoscowResearch Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow20062012200626Том II № 5-6 2006 г.184190Copyright © Голубев А.М., Москалева Е.Ю., Северин С.Е., Веснянко Т.П., Кузовлев А.Н., Алкадарский А.С., Порошенко Г.Г., 20062006Голубев А.М., Москалева Е.Ю., Северин С.Е., Веснянко Т.П., Кузовлев А.Н., Алкадарский А.С., Порошенко Г.Г.Golubev A.M., Moskaleva E.Y., Severin S.E., Vesnyanko T.P., Kouzovlev A.N., Alkadarsky A.S., Poroshenko G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1383

Апоптоз — вариант программируемой гибели клетки. Данный термин ввел Керр (Kerr) и соавт. в 1972 г., но информация о важной роли апоптоза отдельных клеток при критических состояниях появилась лишь в последние годы. В обзоре литературы рассмотрены основные механизмы индукции, развития и регуляции апоптоза. На основе современных данных литературы проанализирована роль апоптоза в патогенезе различных критических состояний: острого повреждения легких (нейтрофиль-ная и эпителиальная гипотезы), сепсиса, инфаркта миокарда и ишемического инсульта (апоптоз при ишемии-реперфузии), острой почечной недостаточности (апоптоз клеток тубулярного эпителия), дисфункции печени при сепсисе, миопатий при критических состояниях. Приведены данные исследований о влиянии ингаляционных и неингаляционных анестетиков на апоптоз нейронов головного мозга и лимфоцитов. В обзоре литературы приводятся варианты терапевтического модулирования апоптоза при помощи фармакологических методов.

 

Apoptosis is a variant of programmed cell death. This term was introduced by Kerr et al. in 1972, but information on the important role of apoptosis of some cells in critical conditions has recently appeared. The review of literature considers the basic mechanisms of induction, development, and regulation of apoptosis. Based on a literature update, the authors analyze the role of apoptosis in the pathogenesis of various critical conditions: acute lung lesion (neutrophilic and epithelial hypotheses), sepsis, myocardial infarction, and ischemic stroke (apoptosis of tubular epithelial cells), hepatic dysfunction in sepsis, myopathies in critical conditions. The data of studies dealing with the effects of inhaled and non-inhaled anesthetics on the apoptosis of neurons of the brain and lymphocytes are given. The review of literature presents the options of therapeutic apoptosis modulation by pharmacological methods.

 

 

 

 

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The authors declare that there are no conflicts of interest present.