rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2012-4-111rmt-1391Research ArticleФУНДАМЕНТАЛЬНЫЕ ОСНОВЫ АНЕСТЕЗИОЛОГИИ-РЕАНИМАТОЛОГИИFUNDAMENTALS OF ANESTHESIOLOGY AND REANIMATOLOGYИзбранные вопросы патогенеза и интенсивного лечения тяжелой сочетанной травмыSelected Issues of the Pathogenesis and Intensive Treatment of Severe Contaminant InjuryГерасимовЛ. В.GerasimovL. V.lev-gerasimov@yandex.ruКарпунН. А.KarpunN. A.ПирожковаО. С.PirozhkovaO. S.20122606201484Том VIII № 4 2012 г.111111Copyright © Герасимов Л.В., Карпун Н.А., Пирожкова О.С., 20122012Герасимов Л.В., Карпун Н.А., Пирожкова О.С.Gerasimov L.V., Karpun N.A., Pirozhkova O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1391

В статье приводятся результаты ряда отечественных исследований за последние 10 лет, посвященных изучению патогенеза и разработке новых методов лечения тяжелой сочетанной травмы, сопровождающейся шоком и кровопотерей. В частности, рассматриваются новые экспериментальные и клинические данные об изменениях гормонального статуса, липидного обмена, гемореологии, микроциркуляции, состояния оксидантно-антиоксидантной, нейроиммунноэндокринной систем, транспорта кислорода. Одновременно обосновываются соответствующие патогенетические принципы лечения больных и пострадавших, при этом особое внимание уделяется возможности применения препаратов с антигипоксантными свойствами и перспективам эфферентных методов терапии. Также приводятся работы, посвященные патогенезу и коррекции гипоксии у отдельных категорий травматических больных, в частности, больных с тупой травмой грудной клетки и пострадавших с минно-взрывными ранениями 

The paper gives the results of a number of Russian studies in the past 10 years on the pathogenesis of severe concomitant injury accompanied by shock and blood loss and development of its new treatment options. In particular, it considers new experimental and clinical data on changes in hormonal status, lipid metabolism, hemorheology, microcirculation, oxidant-antioxidant balance, neuroimmune endocrine system, and oxygen transport. At the same time the respective pathogenetic principles in the treatment of patients and victims are justified, with special emphasis on the use of antihypoxants and prospects for efferent therapeutic techniques. There are also papers on the pathogenesis and correction of hypoxia in individual categories of trauma patients, those with blunt chest injury and mine blast victims in particular. 

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The authors declare that there are no conflicts of interest present.