rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2014-4-6-10rmt-1408Research ArticleРЕДАКЦИОННАЯ СТАТЬЯEDITORIALНОВЫЕ ДИАГНОСТИЧЕСКИЕ КАНДИДАТНЫЕ МОЛЕКУЛЯРНЫЕ БИОМАРКЕРЫ ОСТРОГО РЕСПИРАТОРНОГО ДИСТРЕСССИНДРОМАNew Diagnostic Candidate Molecular Biomarkers of Acute Respiratory Distress SyndromeМорозВ. В.MorozV. V.ГолубевА. М.GolubevA. M.КузовлевА. Н.KuzovlevA. N.artem_kuzovlev@mail.ruПисаревВ. М.PisarevV. M.НИИ общей реаниматологии им. В. А. Неговского, МоскваРоссияV. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowRussian Federation201426082014104610Copyright © Мороз В.В., Голубев А.М., Кузовлев А.Н., Писарев В.М., 20142014Мороз В.В., Голубев А.М., Кузовлев А.Н., Писарев В.М.Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1408

Редакционная статья посвящена разработке алгоритма диагностики и прогноза течения острого респираторного дистресс синдрома (ОРДС), основанного на использовании данных, полученных в НИИ общей реаниматологии им. В. А. Неговского в 2012—2014 гг. Представлены современные подходы к диагностике и лечению ОРДС. Приведены собственные данные и данные зарубежной литературы последних лет, свидетельствующие о потенциале количественного определения сурфактатных белков SPA и SPD, продуцируемых клетками дыхательного эпителия, для раннего диагноза и прогноза течения ОРДС. Предложен новый алгоритм ранней диагностики и прогноза развития ОРДС, основанный на использовании поэтапного определения количественного содержания SPA и SPD в плазме больных при критических состояниях. Циркулирующие молекулы SPA и SPD рассматриваются в качестве кандидатных биомаркеров, имеющих существенную ценность для создания мультипараметрической панели биомаркеров для диагноза и прогноза ОРДС как жизнеугрожающего критического состояния.

Editorial dedicated to the development of the algorithm of diagnosis and prognosis of acute respiratory distress syndrome (ARDS), based on the use of recent data (2012—2014) from the V. A. Negovsky Institute of General reanimatology. Modern approaches to the diagnosis and treatment of ARDS are discussed. Available modern data including results of own recent investigation have clearly demonstrated the potential of quantifying surfactant proteins SPA and SPD, which pro duced by cells of the respiratory epithelium, for the early diagnosis and prognosis of ARDS. A new algorithm for diagnosis and prognosis of ARDS based on a sequential quantification of SPA and SPD molecules in the plasma of patients in crit ical conditions is suggested. Circulating SPA and SPD are considered as valuable candidate biomarkers for developingmultiparametric panel of biomarkers for diagnosis and prognosis of ARDS in patients with lifethreatening critical illness.

..ReferencesMoroz V.V., Golubev A.M. Klassifikatsiya ostrogo respiratornogo dis tresssindroma. Obshchaya Reanimatologiya. [Classification of acute respiratory distress syndrome. General Reanimatology]. 2007; 3 (5—6): 7—9. [In Russ.]Moroz V.V., Golubev A.M. Klassifikatsiya ostrogo respiratornogo dis tresssindroma. Obshchaya Reanimatologiya. [Classification of acute respiratory distress syndrome. General Reanimatology]. 2007; 3 (5—6): 7—9. [In Russ.]Moroz V.V., Golubev A.M. Printsipy diagnostiki rannikh proyavlenii ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Principles in the diagnosis of early manifestations of acute lung lesion. General Reanimatology]. 2006; 2 (4): 5—7. [In Russ.]Moroz V.V., Golubev A.M. Printsipy diagnostiki rannikh proyavlenii ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Principles in the diagnosis of early manifestations of acute lung lesion. General Reanimatology]. 2006; 2 (4): 5—7. [In Russ.]Moroz V.V. (red.). Ostryi respiratornyi distresssindrom: klassifikat siya, diagnostika, differentsirovannoe lechenie. Uchebnometodich eskoe posobie. [Acute respiratory distress syndrome: Classification, diagnosis, differentiated treatment. A teaching guide]. Moscow: NIIOR RAMN; 2013: 99. [In Russ.]Moroz V.V. (red.). Ostryi respiratornyi distresssindrom: klassifikat siya, diagnostika, differentsirovannoe lechenie. Uchebnometodich eskoe posobie. [Acute respiratory distress syndrome: Classification, diagnosis, differentiated treatment. A teaching guide]. Moscow: NIIOR RAMN; 2013: 99. [In Russ.]Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Patogenez i differentsialnaya diagnostika ostrogo respiratornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etiologicheskimi faktorami. Obshchaya Reanimatologiya. [The pathogenesis and differential diagnosis of acute respiratory dis tress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (3): 5—13. [In Russ.]Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Patogenez i differentsialnaya diagnostika ostrogo respiratornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etiologicheskimi faktorami. Obshchaya Reanimatologiya. [The pathogenesis and differential diagnosis of acute respiratory dis tress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (3): 5—13. [In Russ.]Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Differentsirovannoe lechenie ostrogo respira tornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etio logicheskimi faktorami. Obshchaya Reanimatologiya. [Differentiated treat ment for acute respiratory distress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (4): 5—15. [In Russ.]Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Differentsirovannoe lechenie ostrogo respira tornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etio logicheskimi faktorami. Obshchaya Reanimatologiya. [Differentiated treat ment for acute respiratory distress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (4): 5—15. [In Russ.]Marchenkov Yu.V., Vlasenko A.V., Moroz V.V., Yakovlev V.N. Evolyutsiya diagnostiki i lecheniya ostrogo respiratornogo distress sindroma na osnove noveishikh meditsinskikh tekhnologii. Obshchaya Reanimatologiya. [Evolution of the diagnosis and treatment of acute respiratory distress syndrome on the basis of uptodate medical tech nologies. General Reanimatology]. 2012; 8 (4): 22—30. [In Russ.]Marchenkov Yu.V., Vlasenko A.V., Moroz V.V., Yakovlev V.N. Evolyutsiya diagnostiki i lecheniya ostrogo respiratornogo distress sindroma na osnove noveishikh meditsinskikh tekhnologii. Obshchaya Reanimatologiya. [Evolution of the diagnosis and treatment of acute respiratory distress syndrome on the basis of uptodate medical tech nologies. General Reanimatology]. 2012; 8 (4): 22—30. [In Russ.]Agrawal A., Zhuo H., Brady S., Levitt J., Steingrub J., Siegel M.D., Soto G., Peterson M.W., Chesnutt M.S., Matthay M.A., Liu K.D. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am. J. Physiol. Lung Cell Mol. Physiol. 2012; 303 (8): L634—L639. http://dx.doi.org /10.1152/ajplung.00195.2012. PMID: 22865551Agrawal A., Zhuo H., Brady S., Levitt J., Steingrub J., Siegel M.D., Soto G., Peterson M.W., Chesnutt M.S., Matthay M.A., Liu K.D. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am. J. Physiol. Lung Cell Mol. Physiol. 2012; 303 (8): L634—L639. http://dx.doi.org /10.1152/ajplung.00195.2012. PMID: 22865551Cross L., Matthay M. Biomarkers of acute lung injury: insights into the pathogenesis pf acute lung injury. Crit. Care Clin. 2011; 27 (2): 355—377. http://dx.doi.org/10.1016/j.ccc.2010.12.005. PMID: 21440206Cross L., Matthay M. Biomarkers of acute lung injury: insights into the pathogenesis pf acute lung injury. Crit. Care Clin. 2011; 27 (2): 355—377. http://dx.doi.org/10.1016/j.ccc.2010.12.005. PMID: 21440206Flori H.R., Ware L.B., Glidden D., Matthay M.A. Early elevation of plas ma soluble intercellular adhesion molecule1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr. Crit. Care Med. 2003; 4 (3): 315–321. http://dx.doi.org/10. 1097/01.PCC.0000074583.27727.8E. PMID: 12831413Flori H.R., Ware L.B., Glidden D., Matthay M.A. Early elevation of plas ma soluble intercellular adhesion molecule1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr. Crit. Care Med. 2003; 4 (3): 315–321. http://dx.doi.org/10. 1097/01.PCC.0000074583.27727.8E. PMID: 12831413Proudfoot A., Hind M., Griffiths M. Biomarkers of acute lung injury: worth their salt? BMC Med. 2011; 9: 132—140. http://dx.doi.org/10.1186/174170159132. PMID: 22152131Proudfoot A., Hind M., Griffiths M. Biomarkers of acute lung injury: worth their salt? BMC Med. 2011; 9: 132—140. http://dx.doi.org/10.1186/174170159132. PMID: 22152131Grigoryev Ye.V, Churlyaev Yu.A., Razumov A.S. Biomarkery ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Biomarkers of acute lung lesion. General Reanimatology]. 2006; 2 (4): 94—99.Grigoryev Ye.V, Churlyaev Yu.A., Razumov A.S. Biomarkery ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Biomarkers of acute lung lesion. General Reanimatology]. 2006; 2 (4): 94—99.Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Shabanov A.K., Golubev М.А. Surfaktantnyi protein D – biomarker ostrogo respira tornogo distresssindroma. Obshchaya Reanimatologiya. [Surfactant protein D is a biomarker of acute respiratory distress syndrome. General Reanimatology]. 2013; 9 (4): 11—18. [In Russ.]Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Shabanov A.K., Golubev М.А. Surfaktantnyi protein D – biomarker ostrogo respira tornogo distresssindroma. Obshchaya Reanimatologiya. [Surfactant protein D is a biomarker of acute respiratory distress syndrome. General Reanimatology]. 2013; 9 (4): 11—18. [In Russ.]Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Polovnikov S.G., Shabanov A.K., Golubev М.А. Surfaktantnyi protein A (SPA) – prog nostichesky molekulyarnyi biomarker pri ostrom respiratornom dis tresssindrome. Obshchaya Reanimatologiya. [Surfactant protein A (SPA) is a prognostic molecular biomarker in acute respiratory dis tress syndrome. General Reanimatology]. 2013; 9 (3): 5—13. [In Russ.]Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Polovnikov S.G., Shabanov A.K., Golubev М.А. Surfaktantnyi protein A (SPA) – prog nostichesky molekulyarnyi biomarker pri ostrom respiratornom dis tresssindrome. Obshchaya Reanimatologiya. [Surfactant protein A (SPA) is a prognostic molecular biomarker in acute respiratory dis tress syndrome. General Reanimatology]. 2013; 9 (3): 5—13. [In Russ.]Cheng I.W., Ware L.B., Greene K.E., Nuckton T.J., Eisner M.D., Matthay M.A. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003; 31 (1): 20–27. http://dx.doi.org/10.1097/0000324620030100000003. PMID: 12544988Cheng I.W., Ware L.B., Greene K.E., Nuckton T.J., Eisner M.D., Matthay M.A. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003; 31 (1): 20–27. http://dx.doi.org/10.1097/0000324620030100000003. PMID: 12544988Eisner M.D., Parsons P., Matthay M.A., Ware L., Greene K.; Acute Respiratory Distress Syndrome Network. Plasma surfactant protein lev els and clinical outcomes in patients with acute lung injury. Thorax. 2003; 58 (11): 983–988. http://dx.doi.org/10.1136/thorax.58.11.983. PMID: 14586055Eisner M.D., Parsons P., Matthay M.A., Ware L., Greene K.; Acute Respiratory Distress Syndrome Network. Plasma surfactant protein lev els and clinical outcomes in patients with acute lung injury. Thorax. 2003; 58 (11): 983–988. http://dx.doi.org/10.1136/thorax.58.11.983. PMID: 14586055Ware L.B., Koyama T., Zhao Z., Janz D.R., Wickersham N., Bernard G.R., May A.K., Calfee C.S., Matthay M.A. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit. Care. 2013; 17 (5): R253. PMID: 24156650Ware L.B., Koyama T., Zhao Z., Janz D.R., Wickersham N., Bernard G.R., May A.K., Calfee C.S., Matthay M.A. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit. Care. 2013; 17 (5): R253. PMID: 24156650

The authors declare that there are no conflicts of interest present.