rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2014-5-69-86rmt-1423Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSПРЕПАРАТЫ ЛЕГОЧНОГО СУРФАКТАНТА ПРИ ОСТРЫХ И ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЯХ ЛЕГКИХ (Часть II)Pulmonary Surfactants for Acute and Chronic Lung Diseases (Part II)РозенбергО. А.RozenbergO. A.

197758, г. СанктПетербург, Песочный, ул. Ленинградская, 70, Россия

70, Leningradskaya St., Pesochnyi, Saint Petersburg 197758, Russia

rozenberg@biosurf.ruРоссийский научный центр радиологии и хирургических технологий Минздрава РФ, СанктПетербург, РоссияРоссияRussian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, Saint Petersburg, RussiaRussian Federation2014211020141056986Copyright © Розенберг О.А., 20142014Розенберг О.А.Rozenberg O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1423

Во второй части обзора рассматривается проблема сурфактанттерапии острого респираторного дистресссиндрома (ОРДС) у взрослых и детей младшего и старшего возраста. Излагаются сведения о результатах сурфактанттерапии и профилактики ОРДС у больных с тяжелой комбинированной травмой, ингаляционными поражениями, осложнениями при тяжелых расширенных операциях на грудной клетке, при тяжелых пневмониях, в том числе при двусторонней пневмонии на фоне гриппа A/H1N1. Представлены данные о применении сурфактанта в акушерской клинике и профилактике первичной дисфункции легочного трансплантата при трансплантации легких. Обсуждаются результа ты многолетнего использования сурфактанттерапии в России, свидетельствующие о возможности существенного (до 20%) снижения уровня смертности при ОРДС. Кроме того, рассмотриваются примеры сурфактанттерапии других заболеваний легких, таких как стойкие ателектазы, ХОБЛ и бронхиальная астма, а также туберкулез легких.

Part 2 of the review considers the problem of surfactant therapy for acute respiratory distress syndrome (ARDS) in adults and young and old children. It gives information on the results of surfactant therapy and prevention of ARDS in patients with severe concurrent trauma, inhalation injuries, complications due to complex expanded chest surgery, or severe pneumonias, including bilateral pneumonia in the presence of A/H1N1 influenza. There are data on the use of a surfactant in obstetric care and prevention of primary graft dysfunction during lung transplantation. The results of longterm use of surfactant therapy in Russia, suggesting that death rates from ARDS may be substantially reduced (to 20%) are discussed. Examples of surfactant therapy for other noncritical lung diseases, such as permanent athelectasis, chronic obstructive pulmonary diseases, and asthma, as well tuberculosis, are also considered.

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The authors declare that there are no conflicts of interest present.