rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2015-5-45-66rmt-1486Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSЭКСТРАКОРПОРАЛЬНЫЕ МЕТОДЫ ЛЕЧЕНИЯ АБДОМИНАЛЬНОГО СЕПСИСАExtracorporeal Treatments for Abdominal SepsisБажинаЕ. С.BazhinaE. S.НикулинА. В.NikulinA. V.ХорошиловС. Е.KhoroshilovS. E.intensive@list.ruНИИ общей реаниматологии им. В. А. Неговского Россия, 107031, Москва, ул. Петровка, д. 25, стр. 2РоссияV. A. Negovsky Research Institute of General Reanimatology 25, Petrovka St., Build. 2, Moscow 107031, RussiaRussian FederationНИИ общей реаниматологии им. В. А. Неговского Россия, 107031, Москва, ул. Петровка, д. 25, стр. 2 Главный военный клинический госпиталь им. акад. Н. Н. Бурденко МО РФ Россия, 105094, Москва, Госпитальная пл., д. 3РоссияV. A. Negovsky Research Institute of General Reanimatology 25, Petrovka St., Build. 2, Moscow 107031, Russia Acad. N. N. Burdenko Main Military Clinical Hospital, Ministry of Defense of the Russian Federation 3, Gospitalnaya Sq., Moscow 105094, RussiaRussian Federation2015281020151154566Copyright © Бажина Е.С., Никулин А.В., Хорошилов С.Е., 20152015Бажина Е.С., Никулин А.В., Хорошилов С.Е.Bazhina E.S., Nikulin A.V., Khoroshilov S.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1486

Несмотря на значительный прогресс в интенсивном лечении абдоминального сепсиса, летальность от данного заболевания остается крайне высокой. Системный воспалительный ответ на инфекцию характери зуется высвобождением в кровоток эндотоксина и медиаторов воспаления, которые вызывают расстройст ва кровообращения и формирование полиорганной недостаточности. Ультразвуковая высокочастотная допплерография дает возможность динамической оценки тканевой перфузии под воздействием эфферент ного лечения. 

Цель обзора — изложение современных подходов экстракорпорального лечения абдоминального сепси са в свете актуальных представлений о патогенезе бактериальной транслокации, системного воспалитель ного ответа, а также расстройств макрогемодинамики и тканевой перфузии. 

In spite of considerable progress in the intensive treatment of abdominal sepsis, mortality from this disease remains very high. A systemic inflammatory response to infection is characterized by the blood flow release of endotoxin and inflammatory mediators, which cause circulatory disorders and multiple organ dysfunctions. High frequency Doppler ultrasound allows dynamic estimation of tissue perfusion during efferent treatment. 

Objective: to give an account of current approaches to extracorporeal treatment for abdominal sepsis in the light of urgent views on the pathogenesis of bacterial translocation and a systemic inflammatory response, as well as macrohemodynamic disorders and tissue perfusion failure. 

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The authors declare that there are no conflicts of interest present.