rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2015-6-48-60rmt-1499Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSНЕЙРОПРОТЕКТИВНАЯ РОЛЬ ОСНОВНОГО ФАКТОРА РОСТА ФИБРОБЛАСТОВ BFGF ПРИ ИШЕМИЧЕСКОМ ПОВРЕЖДЕНИИ ГОЛОВНОГО МОЗГА (ОБЗОР)NEUROPROTECTIVE ROLE OF BASIC FIBROBLAST GROWTH FACTOR IN ISCHEMIC BRAIN LESION: A REVIEWОстроваИ. В.OstrovaI. V.

Россия, 107031 Москва, ул. Петровка, д. 25, стр. 2

25, Petrovka St., Build. 2, Moscow 107031, Russia

irinaostrova@mail.ruАврущенкоМ. Ш.AvrushchenkoM. Sh.

Россия, 107031 Москва, ул. Петровка, д. 25, стр. 2

25, Petrovka St., Build. 2, Moscow 107031, Russia

irinaostrova@mail.ruНИИ общей реаниматологии им. В. А. НеговскогоРоссияV. A. Negovsky Research Institute of General ReanimatologyRussian Federation2015170120161164860Copyright © Острова И.В., Аврущенко М.Ш., 20162016Острова И.В., Аврущенко М.Ш.Ostrova I.V., Avrushchenko M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1499

Обзор посвящен одному из наиболее известных представителей семейства нейротрофических факторов – основному фактору роста фибробластов bFGF. Обсуждаются его функции в ЦНС в норме и при патологическом воздействии, некоторые механизмы нейропротективного действия, терапевтический потенциал bFGF для лечения функциональных и структурных нарушений нервной системы при ишемии головного мозга различной этиологии, а также при нейродегенеративных заболеваниях. Рассмотрены альтернативные способы доставки этого белка к поврежденным областям головного мозга.

The review deals with basic fibroblast growth factor (bFGF), one of the most known representatives of the family of neutrotrophic factors. It discusses its function in the central nervous system in health and disease, some mechanisms of neuroprotective action, the therapeutic potential of bFGF for the treatment of functional and structural disorders of the nervous system in brain ischemia of different etiologies, and in neurodegenerative diseases. Alternative routes for delivery of this protein to injured cerebral regions are considered.

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The authors declare that there are no conflicts of interest present.