rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2016-5-65-94rmt-1555Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSОСТРАЯ КРОВОПОТЕРЯ: РЕГИОНАРНЫЙ КРОВОТОК И МИКРОЦИРКУЛЯЦИЯ (Обзор, часть II)Acute Blood Loss: Regional Blood Flow and Microcirculation (Review, Part II)МорозВ. В.MorozV. V.

Россия, 107031, г. Москва, ул. Петровка, д. 25, стр. 2

25, Petrovka Str., Build. 2, Moscow 107031, Russia

РыжковИ. А.RyzhkovI. A.

Россия, 107031, г. Москва, ул. Петровка, д. 25, стр. 2

25, Petrovka Str., Build. 2, Moscow 107031, Russia

riamed21@gmail.comНИИ общей реаниматологии им. В. А. НеговскогоРоссияV. A. Negovsky Research Institute of General ReanimatologyRussian Federation2016240120171256594Copyright © Мороз В.В., Рыжков И.А., 20172017Мороз В.В., Рыжков И.А.Moroz V.V., Ryzhkov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1555

первой части обзора было показано, что нарушения системной гемодинамики и микроциркуляции при острой кровопотере ведут к развитию метаболических нарушений и повреждению клеток. Во второй части обзора освещены методы исследования микроциркуляции и оксигенации тканей. Основное внимание уделено современным видам биомикроскопии и методам, основанным на лазерных технологиях. В частности, обсуждается методология использования математического анализа колебаний микрокровотока (флаксмоций) для оценки механизмов регуляции микрогемоциркуляции. Рассмотрены особенности регионарного кровотока и микроциркуляции в различных сосудистых бассейнах организма при острой кровопотере, а также при последующей реперфузии. Показано, что изменения на микроциркуляторном уровне в том или ином органе в значительной степени определяются структурными и функциональными особенностями его кровоснабжения, а также ролью данного органа в патогенезе острой кровопотери. Эти изменения могут иметь как адаптивное, так и патологическое значение в зависимости от стадии и тяжести патологического процесса.

It was shown in the first part of the review that the alterations of systemic hemodynamics and microcirculation in acute blood loss led to the development of metabolic disorders and cell damage. The second part of the review highlights the methods of microcirculation and tissue oxygenation investigation. The focus is on modern biomicroscopy varieties and methods based on the laser technology. In particular, we discuss a method based on the mathematical analysis of microvascular blood flow oscillations (fluxmotion) to evaluate the regulatory mechanisms of microcirculation. The features of regional blood flow and microcirculation in different vascular regions of the body in acute blood loss, as well as during the subsequent reperfusion are considered. It was shown that microcirculatory alterations in a particular organ are largely determined by the structural and functional features of its blood supply, as well as by the role of this organ in the pathogenesis of acute blood loss. These changes can possess both adaptive and pathological significance depending on blood loss stage and severity.

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The authors declare that there are no conflicts of interest present.