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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rmt</journal-id><journal-title-group><journal-title xml:lang="ru">Общая реаниматология</journal-title><trans-title-group xml:lang="en"><trans-title>General Reanimatology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-9779</issn><issn pub-type="epub">2411-7110</issn><publisher><publisher-name>FSBI "SRIGR" RAMS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15360/1813-9779-2017-3-</article-id><article-id custom-type="elpub" pub-id-type="custom">rmt-1565</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФУНДАМЕНТАЛЬНЫЕ ОСНОВЫ АНЕСТЕЗИОЛОГИИ-РЕАНИМАТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FUNDAMENTALS OF ANESTHESIOLOGY AND REANIMATOLOGY</subject></subj-group></article-categories><title-group><article-title>ИНТРАОПЕРАЦИОННАЯ ДИНАМИКА КИСЛОРОДНОГО БАЛАНСА У ПОСТРАДАВШИХ С ПОВРЕЖДЕНИЯМИ ОРГАНОВ БРЮШНОЙ ПОЛОСТИ, ОСЛОЖНЕННЫМИ ОСТРОЙ МАССИВНОЙ КРОВОПОТЕРЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>INTRAOPERATIVE DYNAMICS OF OXYGEN BALANCE IN PATIENTS WITH INJURIES OF ABDOMINAL CAVITY ORGANS COMPLICTED BY ACUTE MASSIVE BLOOD LOSS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конохов</surname><given-names>Павел Вячеславович</given-names></name><name name-style="western" xml:lang="en"><surname>Konokhov</surname><given-names>Pavel Vyacheslavovich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Окончил Амурскую Государственную Академию, специальность "лечебное дело. Ординатура в НИИ СП им. Н.В. Склифосовского по анестезиологии реаниматологии, младший научный соотрудник отделения анестезиологии.</p></bio><email xlink:type="simple">Konohov.pavlik@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ СП им. Н.В. Склифосовского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute of Emergency Care n.a. N.V. Sklifosovskiy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>25</day><month>01</month><year>2018</year></pub-date><volume>13</volume><issue>3</issue><elocation-id>1565</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Конохов П.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Конохов П.В.</copyright-holder><copyright-holder xml:lang="en">Konokhov P.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.reanimatology.com/rmt/article/view/1565">https://www.reanimatology.com/rmt/article/view/1565</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: провести анализ состояния кислородного баланса у пострадавших с повреждениями органов брюшной полости и острой кровопотерей в период оперативного вмешательства и остановки кровотечения.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: в исследованную группу были включены 50 пострадавших - 49 мужчин и 1 женщина среднего возраста 33 (25,75; 44,5) года, с повреждениями органов брюшной полости, осложнившимися острой массивной кровопотерей, требующими проведения экстренного оперативного вмешательства. Тяжесть состояния пациентов по шкале ISS оценивалась в 38 (27,75; 48) баллов. В работе исследовались: объём кровопотери, уровень гемоглобина, гематокрит, газовый состав крови, показатели кислородного баланса, кислотно-основное состояние, содержание электролитов, состояние тканевого метаболизма. Проводилось непрерывное миниинвазивное определение показателей центральной гемодинамики. Статистическую обработку материала проводили с помощью программы SPSS (SPSS Inc., USA).</p></sec><sec><title>Результаты</title><p>Результаты: при поступлении в операционную показатели системной гемодинамики пострадавших не отражали тяжести их состояния. Имелись признаки гиповолемии при нормальных сосудистом тонусе и сердечном выбросе. В то же время тяжесть состояния пострадавших демонстрировали показатели кислородного баланса - высокие ИПО2 и КЭO2, и низкая SvО2. Эти данные свидетельствовали о том, что в период травмы пострадавшие перенесли тяжёлый эпизод дыхательной или циркуляторной гипоксии, которая к моменту поступления в операционную была корригирована в период оказания первичной помощи и при транспортировке, и пострадавшие имели лабораторные признаки «кислородной задолженности». К завершению операции показатели ИПО2 сохранялись высокими вместе с ростом КЭO2. Но низкие значения CvO2, PvO2, SvО2 свидетельствовали о сохраняющейся циркуляторной недостаточности.</p></sec><sec><title>Выводы</title><p>Выводы: Пациенты с развившимися в послеоперационном периоде осложнениями уже поступали в операционную с выраженными нарушениями транспорта кислорода. Пострадавшие не выходили из состояния шока, ведущую роль в сохранении которого играла низкая производительность сердца. Выявлено наличие связи между летальными исходами в послеоперационном периоде и величиной СИ в конце операции у данной категории пострадавших. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to analyze the oxygen balance in patients with injuries of abdominal cavity organs and acute blood loss during the operation and arrest of bleeding.</p></sec><sec><title>Material and methods</title><p>Material and methods: the study group included 50 patients (49 men and 1 woman, average age 33 (25,75; 44,5) years old) suffered from injuries of abdominal cavity organs complicated by acute massive blood loss requiring emergency surgical intervention. The severity of patients’ state was 38 (27,75; 48) scores according to ISS.</p><p>The investigators examined the following parameters: volume of blood loss, hemoglobin (Hg) level, hematocrit (HCT), blood gas composition, indices of oxygen balance, acid-base balance, electrolytes level, and tissue metabolism status. The continuous minimally invasive evaluation of central hemodynamics parameters was conducted.</p><p>The statistical analysis of received data was performed using SPSS software (SPSS Inc., USA).</p></sec><sec><title>Results</title><p>Results: the parameters of central hemodynamics were not representative of the severity of patients’ state at their admission into operative theatre. The signs of hypovolemia were observed along with normal vascular tone and cardiac output. Meanwhile such parameters of oxygen balance as high oxygen consumption index (VO2I) and oxygen extraction ratio (О2ER) as well as low central venous saturation (SvО2) confirmed the critical state of patients. These data testified that patients suffered from severe incident of respiratory or circulatory hypoxia during trauma, which had been corrected during first aid treatment and transportation until patient’s admission into operative theatre, so patients had laboratory findings of «oxygen debt». The high values of VO2I accompanied by increase of О2ER were still observed at the end of surgery while the low values of CvO2, PvO2 and SvО2 testified the continuous circulatory hypoxia.</p></sec><sec><title>Conclusion</title><p>Conclusion: All patients with postoperative complications suffered from severe disturbances of oxygen delivery during preoperative period. The low cardiac efficiency was the main reason for ongoing state of shock at such patients.  The correlation between postoperative lethal outcomes and the value of cardiac index (CI) at the end of surgery in such group of patients was revealed. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Кислородный баланс</kwd><kwd>кислородная задолженность</kwd><kwd>острая кровопотеря</kwd><kwd>циркуляторная недостаточность</kwd><kwd>гипоксия.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oxygen balance</kwd><kwd>oxygen debt</kwd><kwd>acute blood loss</kwd><kwd>circulatory insufficiency</kwd><kwd>hypoxia.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Valetova V.V., Ermolov A.S., Timerbaev V.H., Dragunov A.V. The influence of intraoperative infusion-transfusion therapy on massive blood loss patients lethality. Anesteziologiya i Reanimatologiya. 2012; 2: 23-27. 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