rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2017-3-83-93rmt-1594Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSПатофизиологические аспекты гипероксии в практике анестезиолога реаниматолога (мини-обзор)Pathophysiological Aspects of Hyperoxia in Anesthesiologist-Reanimatologist's PracticeДолгихВ. Т.DolgikhVladimir T.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

prof_dolgih@mail.ruГовороваН. В.GovorovaNatalia V.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

ОрловЮ. П.OrlovYury P.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

КорпачеваО. В.KorpachevaOlga V.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

ДоровскихГ. Н.DorovskikhGalina N.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

ЕршовА. В.ErshovAnton V.

644099, г. Омск, ул. Ленина, д. 12.

12 Lenin Str., Omsk 644099

Омский государственный медицинский университет Минздрава РоссииРоссияOmsk State Medical University, Ministry of Health of RussiaRussian Federation2017300620171338393Copyright © Долгих В.Т., Говорова Н.В., Орлов Ю.П., Корпачева О.В., Доровских Г.Н., Ершов А.В., 20172017Долгих В.Т., Говорова Н.В., Орлов Ю.П., Корпачева О.В., Доровских Г.Н., Ершов А.В.Dolgikh V.T., Govorova N.V., Orlov Y.P., Korpacheva O.V., Dorovskikh G.N., Ershov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1594

Цель обзора — представить потенциально негативные эффекты гипероксии у различных групп боль- ных, находящихся в критическом состоянии, в том числе после остановки сердца, черепно-мозговой трав- мы, инсульта, в случаях развития сепсиса. Приведены доказательства повреждающего эффекта гипероксии и необходимости индивидуального использования кислорода в соответствии с текущей потребностью при ряде патологических процессов и нозологических форм. Описаны механизмы адаптации организма к гипероксии и возможность уменьшения токсических эффектов кислорода с помощью сукцинатов. 

The aim of the review is to present potentially negative effects of hyperoxia in various groups of critically ill patients, including those after cardiac arrest, brain injury or stroke, and in cases of sepsis. It was noted that in cases of these pathological processes and nosological forms there were evidences that hyperoxia could have a damaging effect, and that oxygen should be prescribed on an individual basis depending on the assessment of the current oxy- gen requirement. It has been established that hyperoxia commonly represent the last reserve to abrogate the progressive hypoxia. The mechanisms of adaptation of the body to hyperoxia are described and the possibility to reduce the toxic effects of oxygen with the aid of succinates is discussed. 

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The authors declare that there are no conflicts of interest present.