<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rmt</journal-id><journal-title-group><journal-title xml:lang="ru">Общая реаниматология</journal-title><trans-title-group xml:lang="en"><trans-title>General Reanimatology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-9779</issn><issn pub-type="epub">2411-7110</issn><publisher><publisher-name>FSBI "SRIGR" RAMS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15360/1813-9779-2018-1-12-22</article-id><article-id custom-type="elpub" pub-id-type="custom">rmt-1634</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРИТИЧЕСКИЕ СОСТОЯНИЯ НОВОРОЖДЕННЫХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CRITICAL ILLNESS IN NEWBORNS</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности лечения новорожденных с преходящей ишемией миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the Efficacy of Treatment of Newborns with Transient Myocardial Ischemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Довнар</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dovnar</surname><given-names>Yulia N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Отделение реанимации и интенсивной терапии для новорожденных детей</p><p>125480, г. Москва, ул. Героев Панфиловцев, д. 28 </p></bio><bio xml:lang="en"><p>Neonatal Intensive Care Unit</p><p>28 Heroes Panfilovtsev Str., 125480 Moscow</p></bio><email xlink:type="simple">vesenka@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>Alla A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>2/1 Barricadnaiay Str., Build. 1, 125993 Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Острейков</surname><given-names>И. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostreykov</surname><given-names>Ivan F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Отделение реанимации и интенсивной терапии для новорожденных детей</p><p>125480, г. Москва, ул. Героев Панфиловцев, д. 28 </p><p>125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>Neonatal Intensive Care Unit</p><p>28 Heroes Panfilovtsev Str., 125480 Moscow</p><p>2/1 Barricadnaiay Str., Build. 1, 125993 Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подкопаев</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Podkopaev</surname><given-names>Vladimir N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Отделение реанимации и интенсивной терапии для новорожденных детей</p><p>125480, г. Москва, ул. Героев Панфиловцев, д. 28 </p></bio><bio xml:lang="en"><p>Neonatal Intensive Care Unit</p><p>28 Heroes Panfilovtsev Str., 125480 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Детская Городская Клиническая Больница им. З. А. Башляевой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Z. A. Bashlyaeve Municipal Children's Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного последипломного образования Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Post-Graduate Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Детская Городская Клиническая Больница им. З. А. Башляевой; Российская медицинская академия непрерывного последипломного образования Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Z. A. Bashlyaeve Municipal Children's Clinical Hospital; Russian Medical Academy of Continuous Post-Graduate Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>11</day><month>03</month><year>2018</year></pub-date><volume>14</volume><issue>1</issue><fpage>12</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Довнар Ю.Н., Тарасова А.А., Острейков И.Ф., Подкопаев В.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Довнар Ю.Н., Тарасова А.А., Острейков И.Ф., Подкопаев В.Н.</copyright-holder><copyright-holder xml:lang="en">Dovnar Y.N., Tarasova A.A., Ostreykov I.F., Podkopaev V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.reanimatology.com/rmt/article/view/1634">https://www.reanimatology.com/rmt/article/view/1634</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: комплексная оценка эффективности лечения новорожденных с преходящей ишемией миокарда в отделении реанимации.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. 102 новорожденным с преходящей ишемией миокарда, перенесших анте- и/или интранатальную гипоксию, в возрасте от 1 до 7-и суток жизни со сроком гестации от 29 до 42 недель было проведено клинико-инструментальное исследование сердца до и в процессе терапии. 1-ю группу составили 30 детей с 1-й степенью недостаточности кровообращения, 2-ю группу – 39 детей с 2 А и 3-ю группу – 33 с 2 Б степенью. Все дети получали кардиотрофические препараты, дети 2-й и 3-й групп – кардиотонические препараты.</p></sec><sec><title>Результаты</title><p>Результаты. Установили увеличение биохимических показателей крови (миокардиальной креатинфосфокиназы, лактатдегидрогиназы, аспартатаминотрансферазы, коэффициента де Ритиса), проявлений субэндокардиальной ишемии на электрокардиограмме (депрессия сегмента ST в одном и более отведениях в сочетании с нарушением зубца Т), изменений показателей систолической функции сердца при эхокардиографии (ударного объема, фракций изгнания и укорочения, индекса TEI левого желудочка, минутного объема сердца, сердечного индекса) по мере нарастания степени ишемии миокарда и недостаточности кровообращения и их обратное развитие в процессе лечения. Выявили различные коррелятивные связи между показателями систолической функции левого желудочка и биохимии крови до и в процессе лечения, отражающие дисфункцию миокарда, имеющую постепенное обратное развитие.</p></sec><sec><title>Заключение</title><p>Заключение. У новорожденных с преходящей ишемией миокарда отмечаются нарушения клинико-функционального состояния сердца, зависящие от степени ишемии и недостаточности кровообращения и имеющие постепенное обратное развитие в процессе комплексной интенсивной терапии. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The purpose of the study</title><p>The purpose of the study: a comprehensive assessment of the effectiveness of the treatment of newborns with transient myocardial ischemia in the intensive care unit.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. 102 newborns with transient myocardial ischemia, with a history of ante- and/or intranatal hypoxia, at the age of 1 to 7 days, with a gestational age from 29 to 42 weeks, underwent a clinical and instrumental examination of the heart before and during the treatment. The Group 1 consisted of 30 infants with 1 degree circulatory failure (CF); the Group 2 was comprised of 39 infants with 2A degree of CF, and the Group 3 included 33 infants with the 2B degree of CF. All children received cardiotropic drugs; infants from Groups 2 and 3 received cardiotonic drugs.</p></sec><sec><title>Results</title><p>Results. The study demonstrated an increase in biochemical parameters of blood (myocardial CPK, lactate dehydrogenase, aspartate aminotransferase, de Ritis ratio), manifestations of subendocardial ischemia in the electrocardiogram (depression of ST segment in one or more leads in combination with a T-wave defect), changes in systolic cardiac function during echocardiography (stroke volume, ejection and shortening factions, left ventricular TEI index, cardiac output, and cardiac index) that correlated with the severity of myocardial ischemia and circulatory failure and their reverse development during the treatment. Various correlative links between parameters of left ventricular systolic function and blood biochemistry before and during the treatment reflecting the myocardial dysfunction with a gradual reverse development have been found.</p></sec><sec><title>Conclusion</title><p>Conclusion. Infants with transient myocardial ischemia suffered from disorders of the clinical and functional state of the heart depending on the degree of ischemia and circulatory failure. Most infants exebited gradual reverse development during a complex intensive therapy. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>новорожденные</kwd><kwd>преходящая ишемия миокарда</kwd><kwd>интранатальная гипоксия</kwd><kwd>биохимические маркеры ишемии миокарда</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>newborns</kwd><kwd>transient myocardial ischemia</kwd><kwd>intranatal hypoxia</kwd><kwd>biochemical markers of myocardial ischemia</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Перепелица С.А., Голубев А.М., Мороз В.В., Алексеева С.В. Причины острой интранатальной и постнатальной гипоксии у новорожденных. Общая реаниматология. 2012; 8 (6): 17-22. DOI: 10.15360/1813- 9779-2012-6-17</mixed-citation><mixed-citation xml:lang="en">Perepelitsa S.A., Golubev A.M., Moroz V.V., Alekseyeva S.V. Causes of acute intranatal and postnatal hypoxia in neonatal infants . Obshchaya Reanimatologiya = General Reanimatology. 2012; 8 (6): 17-22. DOI: 10.15360/1813-9779-2012-6-17. [In Russ., In Engl.]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Перепелица С.А. Ранняя постнатальная адаптация новорожденного от матери с сахарным диабетом I типа. Общая реаниматология. 2016; 12 (1): 43-49. DOI: 10.15360/1813-9779-2016-1-43-49</mixed-citation><mixed-citation xml:lang="en">Perepelitsa S.A. Early postnatal adaptation of a newborn from a mother with type I diabetes mellitus. Obshchaya Reanimatologiya = General Reanimatology. 2016; 12 (1): 43-49. DOI: 10.15360/1813-9779-2016-1-43- 49. [In Russ., In Engl.]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Голуб И.Е., Зарубин А.А., Михеева Н.И., Ваняркина А.С., Иванова О.Г. Влияние тяжелой асфиксии в родах на систему гемостаза у ново- рожденных в течении первого часа жизни. Общая реаниматология. 2017; 13 (1): 17-23. DOI: 10.15360/1813-9779-2017-1-17-23</mixed-citation><mixed-citation xml:lang="en">Golub I.E., Zarubin A.A., Mikheyeva N.I., Vanyarkina A.S., Ivanova O.G. The effect of severe birth asphyxia on the hemostasis system in newborns during the first hour of life. Obshchaya Reanimatologiya = General Reanimatology. 2017; 13 (1): 17-23. DOI: 10.15360/1813-9779-2017-1-17- 23. [In Russ., In Engl.]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cherif M., Caputo M., Nakaoka Y., Angelini G.D., Ghorbel M.T. Gab1 is modulated by chronic hypoxia in children with cyanotic congenital heart defect and its overexpression reduces apoptosis in rat neonatal cardiomyocytes. Biomed. Res. Int. 2015; 2015: 718492. DOI: 10.1155/2015/718492. PMID: 26090437</mixed-citation><mixed-citation xml:lang="en">Cherif M., Caputo M., Nakaoka Y., Angelini G.D., Ghorbel M.T. Gab1 is modulated by chronic hypoxia in children with cyanotic congenital heart defect and its overexpression reduces apoptosis in rat neonatal cardiomyocytes. Biomed. Res. Int. 2015; 2015: 718492. DOI: 10.1155/2015/718492. PMID: 26090437</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Neary M.T., Breckenridge R.A. Hypoxia at the heart of sudden infant death syndrome? Pediatr. Res. 2013; 74 (4): 375–379. DOI: 10.1038/pr.2013.122. PMID: 23863852</mixed-citation><mixed-citation xml:lang="en">Neary M.T., Breckenridge R.A. Hypoxia at the heart of sudden infant death syndrome? Pediatr. Res. 2013; 74 (4): 375–379. DOI: 10.1038/pr.2013.122. PMID: 23863852</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Paradis A.N., Gay M.S., Wilson C.G., Zhang L. Newborn hypoxia/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart: role of endothelin-1. PLoS One. 2015; 10 (2): e0116600. DOI: 10.1371/journal.pone.0116600. PMID: 25692855</mixed-citation><mixed-citation xml:lang="en">Paradis A.N., Gay M.S., Wilson C.G., Zhang L. Newborn hypoxia/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart: role of endothelin-1. PLoS One. 2015; 10 (2): e0116600. DOI: 10.1371/journal.pone.0116600. PMID: 25692855</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wei Y., Xu J., Xu T., Fan J., Tao S. Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging. Pediatr. Cardiol. 2009; 30 (6): 741—746. DOI: 10.1007/s00246-009-9421-6. PMID: 19340476</mixed-citation><mixed-citation xml:lang="en">Wei Y., Xu J., Xu T., Fan J., Tao S. Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging. Pediatr. Cardiol. 2009; 30 (6): 741—746. DOI: 10.1007/s00246-009-9421-6. PMID: 19340476</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nestaas E., Støylen A., Brunvand L., Fugelseth D. Longitudinal strain and strain rate by tissue Doppler are more sensitive indices than fractional short ening for assessing the reduced myocardial function in asphyxiated neonates. Cardiol. Young. 2011; 21 (1): 1—7. DOI: 10.1017/S1047951109991314. PMID: 20923594</mixed-citation><mixed-citation xml:lang="en">Nestaas E., Støylen A., Brunvand L., Fugelseth D. Longitudinal strain and strain rate by tissue Doppler are more sensitive indices than fractional shortening for assessing the reduced myocardial function in asphyxiated neonates. Cardiol. Young. 2011; 21 (1): 1—7. DOI: 10.1017/S1047951109991314. PMID: 20923594</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson W.H.Jr., Moller J.H. Pediatric cardiology: the essential pocket guide. 3rd ed. John Wiley &amp; Sons; 2014: 392.</mixed-citation><mixed-citation xml:lang="en">Johnson W.H.Jr., Moller J.H. Pediatric cardiology: the essential pocket guide. 3rd ed. John Wiley &amp; Sons; 2014: 392.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Гутхайль Х., Линдингер А. ЭКГ детей и подростков. М.: ГЭОТАР- Медиа; 2012: 256.</mixed-citation><mixed-citation xml:lang="en">Gutheil H., Lindinger A. ECG of children and adolescents. Moscow: GEOTAR-Media; 2012: 256. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Лебедева Т.Ю., Шибаев А.Н., Гнусаев С.Ф., Федерякина О.Б. Дисфункция синусового узла по данным холтеровского мониторирова- ния у недоношенных новорожденных, перенесших перинатальную гипоксию. Вестн. аритмологии. 2013; 73: 43-48.</mixed-citation><mixed-citation xml:lang="en">Lebedeva T.Yu., Shibaev A.N., Gnusaev S.F., Federyakina O.B. Sinus node dysfunction in premature newborns after perinatal hypoxia according to the holter monitoring data. Vestnik Aritmologii. 2013; 73: 43-48. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wang L., Zhou Y., Li M.X. Evaluation of left ventricular dysfunction by Tei index in neonates with hypoxemia. Zhongguo Dang Dai Er Ke Za Zhi. 2011; 13 (2): 111—114. PMID: 21342618</mixed-citation><mixed-citation xml:lang="en">Wang L., Zhou Y., Li M.X. Evaluation of left ventricular dysfunction by Tei index in neonates with hypoxemia. Zhongguo Dang Dai Er Ke Za Zhi. 2011; 13 (2): 111—114. PMID: 21342618</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bokiniec R., Własienko P., Borszewska-Kornacka M.K., Madajczak D., Szymkiewicz-Dangel J. Myocardial performance index (Tei index) in term and preterm neonates during the neonatal period. Kardiol. Pol. 2016; 74 (9): 1002-1009. DOI: 10.5603/KP.a2016.0056. PMID: 27112943 Armstrong W.F., Thomas T. Feigenbaum’s Echocardiography. 7th</mixed-citation><mixed-citation xml:lang="en">Bokiniec R., Własienko P., Borszewska-Kornacka M.K., Madajczak D., Szymkiewicz-Dangel J. Myocardial performance index (Tei index) in term and preterm neonates during the neonatal period. Kardiol. Pol. 2016; 74 (9): 1002-1009. DOI: 10.5603/KP.a2016.0056. PMID: 27112943 Armstrong W.F., Thomas T. Feigenbaum’s Echocardiography. 7th</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">ed. Philadelphia: Lippincott Williams &amp; Wilkins; 2010: 816.</mixed-citation><mixed-citation xml:lang="en">ed. Philadelphia: Lippincott Williams &amp; Wilkins; 2010: 816.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова А.А. Ультразвуковая диагностика в кардиологии. В кн.: Пыков М.И., Ватолин К.В. Детская ультразвуковая диагностика. М.: Видар; 2001: 125-140.</mixed-citation><mixed-citation xml:lang="en">Tarasova A.A. Ultrasonic diagnostics in cardiology. In: Pykov M.I., Vatolin K.V. Children’s ultrasonic diagnostics. Moscow: Vidar; 2001. 125-140. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Eidem B.W., O’Leary P.W., Cetta F. Echocardiography in pediatric and adult congenital heart disease. Philadelphia: Lippincot Williams &amp; Wilkins; 2010: 500.</mixed-citation><mixed-citation xml:lang="en">Eidem B.W., O’Leary P.W., Cetta F. Echocardiography in pediatric and adult congenital heart disease. Philadelphia: Lippincot Williams &amp; Wilkins; 2010: 500.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Шабалов Н.П. Неонатология. Руководство. т.2. М.: МЕДпресс-информ; 2006: 256.</mixed-citation><mixed-citation xml:lang="en">Shabalov N.P. Neonatology. Guidance. vol.2. Moscow: MEDpress-Inform; 2006: 256. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Лобачева Г.В., Харькин А.В., Манерова А.Ф., Джобава Э.Р. Интенсивная терапия новорожденных и детей первого года жизни с острой сердечной недостаточностью после кардиохирургических вмешательств. Анестезиология и реаниматология. 2010; 5: 23—27. PMID: 21400728</mixed-citation><mixed-citation xml:lang="en">Lobacheva G.V., Kharkin A.V., Manerova A.F., Dzhobava E.R. Intensive care for newborns and babies of the first year of life with acute heart failure after cardiosurgical interventions. Anesteziologiya i Reanimatologiya. 2010; 5: 23—27. PMID: 21400728. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Кисленко О.А., Котлукова Н.П., Рыбалко Н.А. Диагностическое значение различных маркеров миокардиальной дисфункции у детей грудного возраста с патологией сердечно-сосудистой системы. Педиатрия. Журн. им. Г.Н. Сперанского. 2011; 90 (5): 6-11.</mixed-citation><mixed-citation xml:lang="en">Kislenko O.A., Kotlukova N.P., Rybalko N.A. Diagnostic value of various markers of myocardial dysfunction in infants with cardiovascular pathology. Pediatriya. Zhurnal Imeni G.N. Speranskogo. 2011; 90 (5): 6-11. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачук В.А. (ред.). Клиническая биохимия. 2-е изд. М.: ГЭОТАР- Медиа; 2004: 512.</mixed-citation><mixed-citation xml:lang="en">Tkachuk V.A. (ed.). Clinical biochemistry. 2nd ed. Moscow: GEOTARMedia; 2004: 512. [In Russ.]</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Cetin I., Kantar A., Unal S., Cakar N.The assessment of time-dependent myocardial changes in infants with perinatal hypoxia. J. Matern. Fetal. Neonatal. Med. 2012; 25 (9): 1564-1568. DOI: 10.3109/14767058.2011.644365. PMID: 22122298</mixed-citation><mixed-citation xml:lang="en">Cetin I., Kantar A., Unal S., Cakar N.The assessment of time-dependent myocardial changes in infants with perinatal hypoxia. J. Matern. Fetal. Neonatal. Med. 2012; 25 (9): 1564-1568. DOI: 10.3109/14767058.2011.644365. PMID: 22122298</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Сизова Т.М. Статистика. СПб.: СПб НИУ ИТМО; 2013: 176.</mixed-citation><mixed-citation xml:lang="en">Sizova T.M. Statistics. Sankt-Peterburg: Sankt-Peterburg NIU ITMO; 2013: 176. [In Russ.]</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
