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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rmt</journal-id><journal-title-group><journal-title xml:lang="ru">Общая реаниматология</journal-title><trans-title-group xml:lang="en"><trans-title>General Reanimatology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-9779</issn><issn pub-type="epub">2411-7110</issn><publisher><publisher-name>FSBI "SRIGR" RAMS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15360/1813-9779-2018-4-21-34</article-id><article-id custom-type="elpub" pub-id-type="custom">rmt-1699</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МОНИТОРИНГ И ИСХОД КРИТИЧЕСКИХ СОСТОЯНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MONITORING AND OUTCOME OF CRITICAL STATES</subject></subj-group></article-categories><title-group><article-title>Мониторинг эффективности интенсивной терапии и реабилитации по функциональной активности автономной нервной системы у пациентов с повреждениями головного мозга</article-title><trans-title-group xml:lang="en"><trans-title>Monitoring of the Effectiveness of Intensive Care and Rehabilitation by Evaluating the Functional Activity of the Autonomic Nervous System in Patients with Brain Damage</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирячков</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiryachkov</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Yury Yu. Kiryachkov</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><email xlink:type="simple">kirychyu@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гречко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grechko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Andrey V. Grechko</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесов</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesov</surname><given-names>D. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Dmitriy L. Kolesov</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Alexey A. Loginov</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Marina V. Petrova</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубанес</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubanes</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="en"><p>Mohan Rubanes</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пряников</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pryanikov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2</p></bio><bio xml:lang="en"><p>Igor V. Pryanikov</p><p>25 Petrovka Str., Build. 2, 107031 Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный научный клинический центр реаниматологии и реабилитологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution><country>Малайзия</country></aff><aff xml:lang="en"><institution>Peoples Friendship University of Russia</institution><country>Malaysia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2018</year></pub-date><volume>14</volume><issue>4</issue><fpage>21</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кирячков Ю.Ю., Гречко А.В., Колесов Д.Л., Логинов А.А., Петрова М.В., Рубанес М., Пряников И.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кирячков Ю.Ю., Гречко А.В., Колесов Д.Л., Логинов А.А., Петрова М.В., Рубанес М., Пряников И.В.</copyright-holder><copyright-holder xml:lang="en">Kiryachkov Y.Y., Grechko A.V., Kolesov D.L., Loginov A.A., Petrova M.V., Rubanes M., Pryanikov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.reanimatology.com/rmt/article/view/1699">https://www.reanimatology.com/rmt/article/view/1699</self-uri><abstract><sec><title>Цель</title><p>Цель: оценка клинической значимости параметрического мониторинга эффективности интенсивной терапии и реабилитации на основании анализа функционального состояния автономной нервной системы у пациентов с повреждениями головного мозга различного генеза.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включили 66 пациентов на 20—50-е сутки после черепно-мозговой травмы, аноксического повреждения головного мозга; острого нарушения мозгового кровообращения. Выделение клинических групп и последующий анализ клинического статуса основали на оценке функционального состояния автономной нервной системы (АНС) исходя из динамики параметров вариабельности ритма сердца (ВРС). В качестве параметров нормы и патологии функционального состояния АНС апробировали цифровые значения, полученные у 500-а пациентов в периоперационном периоде при 5-и минутной длительности записи ВРС [<xref ref-type="bibr" rid="cit1">1</xref>]. Парасимпатическую гиперактивность принимали в пределах значений для SDNN (стандартное отклонение от средней длительности всех синусовых R-R интервалов) &gt; 41,5 мс; для rMSSD (среднеквадратичное отклонение разности двух смежных отсчетов R-R кардиоинтервалов) &gt; 42,4 мс; для pNN50% (доля соседних синусовых R-R интервалов, которые различаются более чем на 50 мсек) &gt; 8,1%; для SI (стресс-индекс напряжения Баевского, нормализованные единицы) &lt; 80 н. е.; для TP (общая мощность спектра частот) &gt; 2000 мс2. Симпатическая гиперактивность принималась в пределах значений для SDNN &lt; 4,54 мс; для rMSSD &lt; 2,25 мс; для pNN50% &lt; 0,109%; для SI &gt;900 н.е.; для TP &lt; 200 мс2. Норма параметров ВРС принималась в пределах значений для SDNN [13,31—41,4 мс]; для rMSSD [5,78—42,3мс]; для pNN50% [0,110—8,1%]; для SI [80—900 н.е.]; для TP [200—2000 мс2]. Для верификации парасимпатической или симпатической гиперактивности в указанных пределах принимали 3 из 5 параметров [<xref ref-type="bibr" rid="cit1">1</xref>].</p></sec><sec><title>Результаты</title><p>Результаты. По динамике параметров ВРС до и на 30—60-е сутки интенсивной терапии и реабилитации пациентов с травматическими и нетравматическими повреждениями головного мозга выявили 5 клинических групп пациентов. 1-я группа (n=27) — пациенты с нормальными показателями функциональной активности АНС, как в момент поступления в стационар, так и на 30—60-е сутки интенсивной терапии и реабилитации. 2-я группа (n=9) — пациенты с показателями симпатической гиперактивности АНС исходно при поступлении в отделение интенсивной терапии и нормой функциональной активности АНС на 30—60-е сутки проведения курса интенсивной терапии и реабилитации. 3-я группа (n=8) — пациенты с исходными показателями нормы функционального состояния АНС и показателями симпатической гиперактивности АНС на 30—60-е сутки проведения курса интенсивной терапии и реабилитации. 4-я группа (n=15) — пациенты с показателями симпатической гиперактивности АНС как исходно, так и на 30—60-е сутки проведения курса интенсивной терапии и реабилитации. 5-я группа (n=7) — пациенты с показателями парасимпатической гиперактивности АНС (по параметрам ВРС) как исходно при поступлении в отделение интенсивной терапии, так и на 30—60-е сутки проведения интенсивной терапии и реабилитации.</p></sec><sec><title>Заключение</title><p>Заключение. Нормализация параметров ВРС сопровождается выходом пациентов из вегетативного состояния и комы на минимальное сознание или норму сознания, происходит снижение индекса инвалидности и рост социальной реинтеграции по шкале DRS (M. Rappaport, 1982), снижение зависимости от искусственной вентиляции легких, нормализация мышечного тонуса.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: evaluation of the clinical significance of parametric monitoring of the effectiveness of intensive care and rehabilitation based on the analysis of the functional state of the autonomous nervous system in patients with brain damage of different genesis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 66 patients on day 20—50 after the traumatic brain injury; anoxic damage; and stroke consequences. The isolation of clinical groups and subsequent analysis of clinical status is based on the analysis of the functional state of the autonomic nervous system based on the dynamics of the heart rate variability (HRV) parameters. Findings obtained in studies of 500 patients in the postoperative period with a 5-minute HRV were tested as normal and abnormal ANS parameters [<xref ref-type="bibr" rid="cit1">1</xref>]. Parasympathetic hyperactivity was measured within the limits for SDNN (standard deviation of all normal-to-normal R-R intervals) &gt; 41.5 ms; for rMSSD (root-meansquare of the successive normal sinus R-R interval difference) &gt; 42.4 ms; for pNN50% (the percentage of interval differences in successive NN intervals greater than 50 ms (NN50) / total number of NN intervals) &gt; 8.1%; for SI (Baevsky stress index, in normalized units) &lt; 80 n. u.; for TP (total power of variance of all NN intervals) &gt; 2000 ms2. Sympathetic hyperactivity was determined within the limits for following parameters: SDNN, &lt; 4.54 ms; rMSSD, &lt; 2.25 ms; pNN50%, &lt; 0.109%; SI, &gt; 900 n. u.; TP &lt; 200 ms2. Normal HRV parameters were selected within the limits of the values for: SDNN [13.31-41.4ms]; rMSSD [5.78—42.3 ms]; pNN50% [0.110—8.1%]; SI [80—900 nu]; for TP [200—2000 ms2]. To verify the parasympathetic or sympathetic hyperactivity within these limits, 3 of 5 parameters were chosen [<xref ref-type="bibr" rid="cit1">1</xref>].</p></sec><sec><title>Results</title><p>Results. Based on the dynamics of the HRV parameters before the intensive care and on days 30—60 of the intensive therapy and rehabilitation of patients with traumatic and non-traumatic brain injuries, 5 main clinical groups of patients were identified. Group 1 (n=27) consisted of patients with normal parameters of the ANS functional activity (both at the time of admission to the hospital and on the 30—60th day of the intensive therapy and rehabilitation). Group 2 (n=9) included patients with the baseline sympathetic hyperactivity of the ANS at admission to the intensive care unit and normal functional activity of the ANS on the 30—60th day of the intensive care and rehabilitation. Group 3 (n=8) included patients with baseline normal functional state of the ANS and the signs of sympathetic hyperactivity of the ANS on the 30—60th day of the intensive care and rehabilitation. Group 4 (n=15) consisted of patients with signs of sympathetic hyperactivity of the ANS both initially and on the 30—60th day of the intensive care and rehabilitation. Group 5 (n=7) included patients with signs of parasympathetic hyperactivity of the ANS (according to the parameters of HRV) both at baseline, at admission to the intensive care unit, and on the 30—60th day of the intensive care and rehabilitation.</p></sec><sec><title>Conclusion</title><p>Conclusion: The normalization of HRV parameters is accompanied by patients’ recovery from the vegetative state and coma to minimal consciousness or normal consciousness; the index of disability rate decreases, the social reintegration grows, according to the DRS scale (M. Rappaport, 1982); dependence on mechanical ventilation reduces, and the muscle tone normalizes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нейромониторинг</kwd><kwd>вариабельность сердечного ритма</kwd><kwd>симпатическая и парасимпатическая гиперактивность</kwd><kwd>клинический кластер синдромов последствий черепно-мозговой травмы</kwd><kwd>аноксии мозга</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuromonitoring</kwd><kwd>heart rate variability</kwd><kwd>sympathetic and parasympathetic hyperactivity</kwd><kwd>craniocerebral trauma</kwd><kwd>brain anoxia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кирячков Ю.Ю., Салтанов А.И., Хмелевский Я.М. Компьютерный анализ вариабельности ритма сердца. Новые возможности для анестезиолога и врачей других специальностей. 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