rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2018-5-58-84rmt-1714Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSСистема гемостаза в норме и при трансплантации печени (обзор)The System of Blood Coagulation in Normal and in Liver Transplantation (Review)РешетнякВ. И.ReshetnyakV. I.

Василий Решетняк

107031, Москва, ул. Петровка, д. 25, стр. 2

Vasiliy I. Reshetnyak

25 Petrovka Str., Build. 2, Moscow 107031

vasiliy.reshetnyak@yandex.ruЖуравельС. В.ZhuravelS. V.

129090, г. Москва, Большая Сухаревская пл., д. 3

Sergey V. Zhuravel

3 Bolshaya Sukharevskaya Square, Moscow 129090

КузнецоваН. К.KuznetsovaN. K.

129090, г. Москва, Большая Сухаревская пл., д. 3

Natalia K. Kuznetsova

3 Bolshaya Sukharevskaya Square, Moscow 129090

ПисаревВ. М.PisarevV. М.

107031, Москва, ул. Петровка, д. 25, стр. 2

Vladimir M. Pisarev

25 Petrovka Str., Build. 2, Moscow 107031

КлычниковаЕ. В.KlychnikovaE. V.

129090, г. Москва, Большая Сухаревская пл., д. 3

Elena V. Klychnikova

3 Bolshaya Sukharevskaya Square, Moscow 129090

СюткинВ. Е.SyutkinV. Е.

129090, г. Москва, Большая Сухаревская пл., д. 3

Vladimir E. Syutkin

3 Bolshaya Sukharevskaya Square, Moscow 129090

РешетнякТ. М.ReshetnyakТ. M.

115522, Москва, Каширское шоссе, д. 34А 

Tatiana M. Reshetnyak

34A Kashirskoye highway, Moscow 115522

НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРРоссияV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyRussian FederationНИИ скорой помощи им. Н. В. Склифосовского Департамента здравоохранения г. МосквыРоссияN.V. Sklifosovsky Research Institute of Emergency Care, Moscow Healthcare DepartmentRussian FederationНИИ ревматологии им. В. А. НасоновойРоссияV. A. Nasonova Research Institute of RheumatologyRussian Federation2018281020181455884Copyright © Решетняк В.И., Журавель С.В., Кузнецова Н.К., Писарев В.М., Клычникова Е.В., Сюткин В.Е., Решетняк Т.М., 20182018Решетняк В.И., Журавель С.В., Кузнецова Н.К., Писарев В.М., Клычникова Е.В., Сюткин В.Е., Решетняк Т.М.Reshetnyak V.I., Zhuravel S.V., Kuznetsova N.K., Pisarev V.М., Klychnikova E.V., Syutkin V.Е., Reshetnyak Т.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1714

Обзор посвящен проблеме нарушений в системе гемостаза и их коррекции в периоперационном периоде у пациентов, подвергающихся трансплантации печени. Обсуждаются: физиология системы гемостаза; нарушения функции свертывающей системы крови у пациентов на различных стадиях операции трансплантации печени; коррекция нарушений гемостаза во время и после ортотопической трансплантации печени. Трансплантация печени выполняется пациентам с заболеваниями печени в терминальной стадии печеночно-клеточной недостаточности. При этом изменения в системе гемостаза этих больных представляют значительный риск развития, как кровотечений, так и тромбозов во время и после трансплантации печени. Коррекция нарушений гемостаза при трансплантации печени должна проходить с учетом нозологической формы повреждения печени, механизмов развития нарушений гемостаза реципиента и этапа операции.

The review dwells on the problem of hemostatic disorders in patients undergoing liver transplantation and their correction in the perioperative period. The physiology of the hemostatic system, disorders of the blood coagulation system in patients at various stages of liver transplantation, correction of hemostatic disorders during and after orthotopic liver transplantation are discussed. Liver transplantation is performed in patients with liver diseases in the terminal stage of liver failure. At the same time, changes in the hemostatic system of these patients pose a significant risk of developing bleeding and/or thrombosis during and after liver transplantation. The hypothesis is suggested that the personalized correction of hemostasis disorder in liver transplantation should be based on considerating the nosological forms of the liver damage, mechanisms of development of recipient’s hemostatic disorders, and the stage of the surgery.

гемостазтрансплантация печенисвертывающая система кровипериоперационный периодhemostasisliver transplantationcoagulationperioperative periodReferencesStarzl T.E., Demetris A.J. Liver transplantation: a 31-year perspective. Chicago, London, Boca Raton, Littleton, Mass: Year book medical publishers, Inc.; 1990: 206. ISBN: 0-8151-7931-6Starzl T.E., Demetris A.J. Liver transplantation: a 31-year perspective. Chicago, London, Boca Raton, Littleton, Mass: Year book medical publishers, Inc.; 1990: 206. ISBN: 0-8151-7931-6Oldenburg J., Marinova M., Müller-Reible C., Watzka M. The vitamin K cycle. Vitam. Horm. 2008; 78: 35-62. DOI: 10.1016/S00836729(07)00003-9. PMID: 18374189Oldenburg J., Marinova M., Müller-Reible C., Watzka M. The vitamin K cycle. Vitam. Horm. 2008; 78: 35-62. DOI: 10.1016/S00836729(07)00003-9. PMID: 18374189Bandyopadhyay P.K., Garrett J.E., Shetty R.P., Keate T., Walker C.S., Olivera B.M. gamma-Glutamyl carboxylation: an extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates. Proc. Natl. Acad. Sci. USA. 2002; 99 (3): 12641269. DOI: 10.1073/pnas.022637099. PMID: 11818531Bandyopadhyay P.K., Garrett J.E., Shetty R.P., Keate T., Walker C.S., Olivera B.M. gamma-Glutamyl carboxylation: an extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates. Proc. Natl. Acad. Sci. USA. 2002; 99 (3): 12641269. DOI: 10.1073/pnas.022637099. PMID: 11818531Bandyopadhyay P.K. Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification. Vitam. Horm. 2008; 78: 157-184. DOI: 10.1016/S0083-6729(07)00008-8. PMID: 18374194Bandyopadhyay P.K. Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification. Vitam. Horm. 2008; 78: 157-184. DOI: 10.1016/S0083-6729(07)00008-8. PMID: 18374194Morrissey J.H. Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int. J. Hematol. 2004; 79 (2): 103-108. DOI: 10.1532/IJH97.03167. PMID: 15005335Morrissey J.H. Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int. J. Hematol. 2004; 79 (2): 103-108. DOI: 10.1532/IJH97.03167. PMID: 15005335Hanson S.R., Griffin J.H., Harker L.A., Kelly A.B., Esmon C.T., Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J. Clin. Invest. 1993; 92 (4): 2003-2012. DOI: 10.1172/JCI116795. PMID: 8408654Hanson S.R., Griffin J.H., Harker L.A., Kelly A.B., Esmon C.T., Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J. Clin. Invest. 1993; 92 (4): 2003-2012. DOI: 10.1172/JCI116795. PMID: 8408654Shaw A.W., Pureza V.S., Sligar S.G., Morrissey J.H. The local phospholipid environment modulates the activation of blood clotting. J. Biol. Chem. 2007; 282 (9): 6556-6563. DOI: 1074/jbc.M607973200. PMID: 17200119Shaw A.W., Pureza V.S., Sligar S.G., Morrissey J.H. The local phospholipid environment modulates the activation of blood clotting. J. Biol. Chem. 2007; 282 (9): 6556-6563. DOI: 1074/jbc.M607973200. PMID: 17200119Morrissey J.H., Pureza V., Davis-Harrison R.L., Sligar S.G., Ohkubo Y.Z., Tajkhorshid E. Blood clotting reactions on nanoscale phospholipid bilayers. Thromb. Res. 2008; 122 (Suppl 1): S23-S26. DOI: 10.1016/S00493848(08)70014-8. PMID: 18691494Morrissey J.H., Pureza V., Davis-Harrison R.L., Sligar S.G., Ohkubo Y.Z., Tajkhorshid E. Blood clotting reactions on nanoscale phospholipid bilayers. Thromb. Res. 2008; 122 (Suppl 1): S23-S26. DOI: 10.1016/S00493848(08)70014-8. PMID: 18691494Smith S.A., Morrissey J.H. Polyphosphate: a new player in the field of hemostasis. Curr. Opin. Hematol. 2014; 21 (5): 388-394. DOI: 10.1097/MOH.0000000000000069. PMID: 25010799Smith S.A., Morrissey J.H. Polyphosphate: a new player in the field of hemostasis. Curr. Opin. Hematol. 2014; 21 (5): 388-394. DOI: 10.1097/MOH.0000000000000069. PMID: 25010799Morrissey J.H., Davis-Harrison R.L., Tavoosi N., Ke K., Pureza V., Boettcher J.M., Clay M.C., Rienstra C.M., Ohkubo Y.Z., Pogorelov T.V., Tajkhorshid E. Protein-phospholipid interactions in blood clotting. Thromb. Res. 2010; 125 (Suppl 1): S23-S25. DOI: 10.1016/j.thromres.2010.01.027. PMID: 20129649Morrissey J.H., Davis-Harrison R.L., Tavoosi N., Ke K., Pureza V., Boettcher J.M., Clay M.C., Rienstra C.M., Ohkubo Y.Z., Pogorelov T.V., Tajkhorshid E. Protein-phospholipid interactions in blood clotting. Thromb. Res. 2010; 125 (Suppl 1): S23-S25. DOI: 10.1016/j.thromres.2010.01.027. PMID: 20129649Ke K., Yuan J., Morrissey J.H. Tissue factor residues that putatively interact with membrane phospholipids. PLoS One. 2014; 9 (2): e88675. DOI: 10.1371/journal.pone.0088675. PMID: 24516673Ke K., Yuan J., Morrissey J.H. Tissue factor residues that putatively interact with membrane phospholipids. PLoS One. 2014; 9 (2): e88675. DOI: 10.1371/journal.pone.0088675. PMID: 24516673Tavoosi N., Smith S.A., Davis-Harrison R.L., Morrissey J.H. Factor VII and protein C arephosphatidic acid-binding proteins. Biochemistry. 2013; 52 (33): 5545-5552. DOI: 10.1021/bi4006368. PMID: 23879866Tavoosi N., Smith S.A., Davis-Harrison R.L., Morrissey J.H. Factor VII and protein C arephosphatidic acid-binding proteins. Biochemistry. 2013; 52 (33): 5545-5552. DOI: 10.1021/bi4006368. PMID: 23879866Morawitz P. Beiträge zur Kenntnis der Blutgerinnung. Beitr. chem. Physiol. Pathol. 1904; 5: 133-141.Morawitz P. Beiträge zur Kenntnis der Blutgerinnung. Beitr. chem. Physiol. Pathol. 1904; 5: 133-141.Morawitz P. Beiträge zur Kenntnis der Blutgerinnung. 2. Mitteilung. Arch. Klin. Med. 1904; 79: 215-233.Morawitz P. Beiträge zur Kenntnis der Blutgerinnung. 2. Mitteilung. Arch. Klin. Med. 1904; 79: 215-233.Nahas L., Macfarlane R.G., Denson K.W. A study of the coagulant action of eight snake venoms. Thromb. Diath. Haemorrh. 1964; 12: 355-367. PMID: 14254694Nahas L., Macfarlane R.G., Denson K.W. A study of the coagulant action of eight snake venoms. Thromb. Diath. Haemorrh. 1964; 12: 355-367. PMID: 14254694Davie E.W., Ratnoff O.D. Waterfall sequence for intrinsic blood clotting. Science. 1964; 145 (3638): 1310-1312. DOI: 10.1126/science.145.3638.1310. PMID: 14173416Davie E.W., Ratnoff O.D. Waterfall sequence for intrinsic blood clotting. Science. 1964; 145 (3638): 1310-1312. DOI: 10.1126/science.145.3638.1310. PMID: 14173416Broze G.J.Jr. Tissue factor pathway inhibitor and the current concept of blood coagulation. Blood Coagul. Fibrinolysis. 1995; 6 (Suppl 1): S7-S13. DOI: 10.1097/00001721-199506001-00002. PMID: 7647225Broze G.J.Jr. Tissue factor pathway inhibitor and the current concept of blood coagulation. Blood Coagul. Fibrinolysis. 1995; 6 (Suppl 1): S7-S13. DOI: 10.1097/00001721-199506001-00002. PMID: 7647225Hoffman M.A., Monroe D.M.3rd. Сell-based model of hemostasis. Thromb. Haemost. 2001; 85 (6): 958-965. PMID: 11434702Hoffman M.A., Monroe D.M.3rd. Сell-based model of hemostasis. Thromb. Haemost. 2001; 85 (6): 958-965. PMID: 11434702Stout R.W., Crawford V. Seasonal variations in fibrinogen concentrations among elderly people. Lancet. 1991; 338 (8758): 9-13. DOI: 10.1016/0140-6736(91)90004-9. PMID: 1676131Stout R.W., Crawford V. Seasonal variations in fibrinogen concentrations among elderly people. Lancet. 1991; 338 (8758): 9-13. DOI: 10.1016/0140-6736(91)90004-9. PMID: 1676131Stout R.W., Crawford V.L., McDermott M.J., Rocks M.J., Morris T.C. Seasonal changes in haemostatic factors in young and elderly subjects. Age Ageing. 1996; 25 (3): 256-258. DOI: 10.1093/ageing/25.3.256. PMID: 8670564Stout R.W., Crawford V.L., McDermott M.J., Rocks M.J., Morris T.C. Seasonal changes in haemostatic factors in young and elderly subjects. Age Ageing. 1996; 25 (3): 256-258. DOI: 10.1093/ageing/25.3.256. PMID: 8670564Hermida R.C., Calvo C., Ayala D.E., López J.E., Fernández J.R., Mojón A., Domínguez M.J., Covelo M. Seasonal variation of fibrinogen in dipper and nondipper hypertensive patients. Circulation. 2003; 108 (9): 1101-1106. DOI: 10.1161/01.CIR.0000085992.67380.7B. PMID: 12912809Hermida R.C., Calvo C., Ayala D.E., López J.E., Fernández J.R., Mojón A., Domínguez M.J., Covelo M. Seasonal variation of fibrinogen in dipper and nondipper hypertensive patients. Circulation. 2003; 108 (9): 1101-1106. DOI: 10.1161/01.CIR.0000085992.67380.7B. PMID: 12912809Hall T.H., Dhir A. Anesthesia for liver transplantation. Semin. Cardiothorac. Vasc. Anesth. 2013; 17 (3): 180-194. DOI: 10.1177/108925321 3481115. PMID: 23482506Hall T.H., Dhir A. Anesthesia for liver transplantation. Semin. Cardiothorac. Vasc. Anesth. 2013; 17 (3): 180-194. DOI: 10.1177/1089253 213481115. PMID: 23482506Palomo Sanchez J.C., Jimenez C., Moreno Gonzalez E., Garcia I., Palma F., Loinaz C., Gonzalez Ghamorro A. Effects of intraoperative blood transfusion on postoperative complications and survival after orthotopic liver transplantation. Hepatogastroenterology. 1998; 45 (22): 1026–1033. PMID: 9756002Palomo Sanchez J.C., Jimenez C., Moreno Gonzalez E., Garcia I., Palma F., Loinaz C., Gonzalez Ghamorro A. Effects of intraoperative blood transfusion on postoperative complications and survival after orthotopic liver transplantation. Hepatogastroenterology. 1998; 45 (22): 1026–1033. PMID: 9756002Cleland S., Corredor C., Ye J.J., Srinivas C., McCluskey S.A. Massive haemorrhage inliver transplantation: сonsequences, prediction and management. World J. Transplant. 2016; 6 (2): 291-305. DOI: 10.5500/wjt.v6.i2.291. PMID: 27358774Cleland S., Corredor C., Ye J.J., Srinivas C., McCluskey S.A. Massive haemorrhage inliver transplantation: сonsequences, prediction and management. World J. Transplant. 2016; 6 (2): 291-305. DOI: 10.5500/wjt.v6.i2.291. PMID: 27358774Kang Y.G., Martin D.J., Marquez J., Lewis J.H., Bontempo F.A., Shaw B.W.Jr., Starzl T.E., Winter P.M. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth. Analg. 1985; 64 (9): 888–896. DOI: 10.1213/00000539198509000-00008. PMID: 3896028Kang Y.G., Martin D.J., Marquez J., Lewis J.H., Bontempo F.A., Shaw B.W.Jr., Starzl T.E., Winter P.M. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth. Analg. 1985; 64 (9): 888–896. DOI: 10.1213/00000539198509000-00008. PMID: 3896028Kriz N., Rinder C.S., Rinder H.M. Physiology of hemostasis: with relevance to current and future laboratory testing. Clin. Lab. Med. 2009; 29 (2): 159-174. DOI: 10.1016/j.cll.2009.06.004. PMID: 19665673Kriz N., Rinder C.S., Rinder H.M. Physiology of hemostasis: with relevance to current and future laboratory testing. Clin. Lab. Med. 2009; 29 (2): 159-174. DOI: 10.1016/j.cll.2009.06.004. PMID: 19665673Rana A., Petrowsky H., Hong J.C., Agopian V.G., Kaldas F.M., Farmer D., Yersiz H., Hiatt J.R., Busuttil R.W. Blood transfusion requirement during liver transplantation is an important risk factor for mortality. J. Am. Coll. Surg. 2013; 216 (5): 902–907. DOI: 10.1016/j.jamcollsurg.2012.12.047. PMID: 23478547Rana A., Petrowsky H., Hong J.C., Agopian V.G., Kaldas F.M., Farmer D., Yersiz H., Hiatt J.R., Busuttil R.W. Blood transfusion requirement during liver transplantation is an important risk factor for mortality. J. Am. Coll. Surg. 2013; 216 (5): 902–907. DOI: 10.1016/j.jamcollsurg.2012.12.047. PMID: 23478547Pereboom I.T., de Boer M.T., Haagsma E.B., Hendriks H.G., Lisman T., Porte R.J. Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth. Analg. 2009; 108 (4): 1083–1091. DOI: 10.1213/ane.0b013e3181948a59. PMID: 19299765Pereboom I.T., de Boer M.T., Haagsma E.B., Hendriks H.G., Lisman T., Porte R.J. Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth. Analg. 2009; 108 (4): 1083–1091. DOI: 10.1213/ane.0b013e3181948a59. PMID: 19299765Steib A., Freys G., Lehmann C., Meyer C., Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can. J. Anaesth. 2001; 48 (11): 1075– 1079. DOI: 10.1007/BF03020372. PMID: 11744582Steib A., Freys G., Lehmann C., Meyer C., Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can. J. Anaesth. 2001; 48 (11): 1075– 1079. DOI: 10.1007/BF03020372. PMID: 11744582Massicotte L., Beaulieu D., Roy J.D., Marleau D., Vandenbroucke F., Dagenais M., Lapointe R., Roy A. MELD score and blood product requirements during liver transplantation: no link. Transplantation. 2009; 87 (11): 16891694. DOI: 10.1097/TP.0b013e3181a5e5f1. PMID: 19502961Massicotte L., Beaulieu D., Roy J.D., Marleau D., Vandenbroucke F., Dagenais M., Lapointe R., Roy A. MELD score and blood product requirements during liver transplantation: no link. Transplantation. 2009; 87 (11): 16891694. DOI: 10.1097/TP.0b013e3181a5e5f1. PMID: 19502961Mangus R.S., Kinsella S.B., Nobari M.M., Fridell J.A., Vianna R.M., Ward E.S., Nobari R., Tector A.J. Predictors of blood product use in orthotopic liver transplantation using the piggyback hepatectomy technique. Transplant. Proc. 2007; 39 (10): 3207–3213. DOI: 10.1016/j.transproceed.2007.09.029. PMID: 18089355Mangus R.S., Kinsella S.B., Nobari M.M., Fridell J.A., Vianna R.M., Ward E.S., Nobari R., Tector A.J. Predictors of blood product use in orthotopic liver transplantation using the piggyback hepatectomy technique. Transplant. Proc. 2007; 39 (10): 3207–3213. DOI: 10.1016/j.transproceed.2007.09.029. PMID: 18089355Feng Z.Y., Jin X.D., Chen Y.Z. Predictors of massive blood transfusion in liver transplantation for patients with benign end-stage liver disease. Zhonghua Yi Xue Za Zhi. 2008; 88: 3040–3044. PMID: 19192401Feng Z.Y., Jin X.D., Chen Y.Z. Predictors of massive blood transfusion in liver transplantation for patients with benign end-stage liver disease. Zhonghua Yi Xue Za Zhi. 2008; 88: 3040–3044. PMID: 19192401Li C., Mi K., Wen T.F., Yan L.N., Li B., Wei Y.G., Yang J.Y., Xu M.Q., Wang W.T. Risk factors and outcomes of massive red blood cell transfusion following living donor liver transplantation. J. Dig. Dis. 2012; 13 (3): 161– 167. DOI: 10.1111/j.1751-2980.2011.00570.x. PMID: 22356311Li C., Mi K., Wen T.F., Yan L.N., Li B., Wei Y.G., Yang J.Y., Xu M.Q., Wang W.T. Risk factors and outcomes of massive red blood cell transfusion following living donor liver transplantation. J. Dig. Dis. 2012; 13 (3): 161– 167. DOI: 10.1111/j.1751-2980.2011.00570.x. PMID: 22356311Tao Y.F., Teng F., Wang Z.X., Guo W.Y., Shi X.M., Wang G.H., Ding G.S., Fu Z.R. Liver transplant recipients with portal vein thrombosis: a single center retrospective study. Hepatobiliary Pancreat. Dis. Int. 2009; 8 (1): 34–39. PMID: 19208512Tao Y.F., Teng F., Wang Z.X., Guo W.Y., Shi X.M., Wang G.H., Ding G.S., Fu Z.R. Liver transplant recipients with portal vein thrombosis: a single center retrospective study. Hepatobiliary Pancreat. Dis. Int. 2009; 8 (1): 34–39. PMID: 19208512Esmat Gamil M., Pirenne J., Van Malenstein H., Verhaegen M., Desschans B., Monbaliu D., Aerts R., Laleman W., Cassiman D., Verslype C., Van Steenbergen W., Van Pelt J., Nevens F. Risk factors for bleeding and clinical implications in patients undergoing liver transplantation. Transplant. Proc. 2012; 44 (9): 2857–2860. DOI: 10.1016/j.transproceed.2012.09.085. PMID: 23146542Esmat Gamil M., Pirenne J., Van Malenstein H., Verhaegen M., Desschans B., Monbaliu D., Aerts R., Laleman W., Cassiman D., Verslype C., Van Steenbergen W., Van Pelt J., Nevens F. Risk factors for bleeding and clinical implications in patients undergoing liver transplantation. Transplant. Proc. 2012; 44 (9): 2857–2860. DOI: 10.1016/j.transproceed.2012.09.085. PMID: 23146542Varotti G., Santori G., Andorno E., Morelli N., Ertreo M., Strada P., Porcile E., Casaccia M., Centanaro M., Valente U. Impact of Model for End-Stage Liver Disease score on transfusion rates in liver transplantation. Transplant. Proc. 2013; 45 (7): 2684–2688. DOI: 10.1016/j.transproceed.2013.07.006. PMID: 24034024Varotti G., Santori G., Andorno E., Morelli N., Ertreo M., Strada P., Porcile E., Casaccia M., Centanaro M., Valente U. Impact of Model for End-Stage Liver Disease score on transfusion rates in liver transplantation. Transplant. Proc. 2013; 45 (7): 2684–2688. DOI: 10.1016/j.transproceed.2013.07.006. PMID: 24034024De Santis G.C., Brunetta D.M., Nardo M., Oliveira L.C., Souza F.F., Cagnolati D., Mente К.D., Sankarankutty A.K., Covas D.T., de Castro e Silva O. Preoperative variables associated with transfusion requirements in orthotopic liver transplantation. Transfus. Apher. Sci. 2014; 50 (1): 99–105. DOI: 10.1016/j.transci.2013.10.006. PMID: 24291115De Santis G.C., Brunetta D.M., Nardo M., Oliveira L.C., Souza F.F., Cagnolati D., Mente К.D., Sankarankutty A.K., Covas D.T., de Castro e Silva O. Preoperative variables associated with transfusion requirements in orthotopic liver transplantation. Transfus. Apher. Sci. 2014; 50 (1): 99–105. DOI: 10.1016/j.transci.2013.10.006. PMID: 24291115Cywinski J.B., Alster J.M., Miller C., Vogt D.P., Parker B.M. Prediction of intraoperative transfusion requirements during orthotopic liver transplantation and the influence on postoperative patient survival. Anesth. Analg. 2014; 118 (2): 428–437. DOI: 10.1213/ANE.0b013e3182a76f19. PMID: 24445640Cywinski J.B., Alster J.M., Miller C., Vogt D.P., Parker B.M. Prediction of intraoperative transfusion requirements during orthotopic liver transplantation and the influence on postoperative patient survival. Anesth. Analg. 2014; 118 (2): 428–437. DOI: 10.1213/ANE.0b013e3182a76f19. PMID: 24445640Ramos E., Dalmau A., Sabate A., Lama C., Llado L., Figueras J., Jaurrieta E. Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl. 2003; 9 (12): 1320–1327. DOI: 10.1016/jlts.2003.50204. PMID: 14625833Ramos E., Dalmau A., Sabate A., Lama C., Llado L., Figueras J., Jaurrieta E. Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl. 2003; 9 (12): 1320–1327. DOI: 10.1016/jlts.2003.50204. PMID: 14625833Fan S.T., Yong B.H., Lo C.M., Liu C.L., Wong J. Right lobe living donor liver transplantation with or without venovenous bypass. Br. J. Surg. 2003; 90 (1): 48–56. DOI: 10.1002/bjs.4026. PMID: 12520574Fan S.T., Yong B.H., Lo C.M., Liu C.L., Wong J. Right lobe living donor liver transplantation with or without venovenous bypass. Br. J. Surg. 2003; 90 (1): 48–56. DOI: 10.1002/bjs.4026. PMID: 12520574Busque S., Esquivel C.O., Concepcion W., So S.K. Experience with the piggyback technique without caval occlusion in adult orthotopic liver transplantation. Transplantation. 1998; 65 (1): 77–82. DOI: 10.1097/00007890-199801150-00015. PMID: 9448148Busque S., Esquivel C.O., Concepcion W., So S.K. Experience with the piggyback technique without caval occlusion in adult orthotopic liver transplantation. Transplantation. 1998; 65 (1): 77–82. DOI: 10.1097/00007890-199801150-00015. PMID: 9448148Hosein Shokouh-Amiri M., Osama Gaber A., Bagous W.A., Grewal H.P., Hathaway D.K., Vera S.R., Stratta R.J., Bagous T.N., Kizilisik T. Choice of surgical technique influences perioperative outcomes in liver transplantation. Ann. Surg. 2000; 231 (6): 814–823. DOI: 10.1097/00000658200006000-00005. PMID: 10816624Hosein Shokouh-Amiri M., Osama Gaber A., Bagous W.A., Grewal H.P., Hathaway D.K., Vera S.R., Stratta R.J., Bagous T.N., Kizilisik T. Choice of surgical technique influences perioperative outcomes in liver transplantation. Ann. Surg. 2000; 231 (6): 814–823. DOI: 10.1097/00000658200006000-00005. PMID: 10816624Nishida S., Nakamura N., Vaidya A., Levi D.M., Kato T., Nery J.R., Madariaga J.R., Molina E., Ruiz P., Gyamfi A., Tzakis A.G. Piggyback technique in adult orthotopic liver transplantation: an analysis of 1067 liver transplants at a single center. HPB (Oxford). 2006; 8 (3): 182–188. DOI: 10.1080/13651820500542135. PMID: 18333273Nishida S., Nakamura N., Vaidya A., Levi D.M., Kato T., Nery J.R., Madariaga J.R., Molina E., Ruiz P., Gyamfi A., Tzakis A.G. Piggyback technique in adult orthotopic liver transplantation: an analysis of 1067 liver transplants at a single center. HPB (Oxford). 2006; 8 (3): 182–188. DOI: 10.1080/13651820500542135. PMID: 18333273Senzolo M., Burra P., Cholongitas E., Burroughs A.K. New insights into the coagulopathy of liver disease and liver transplantation. World J. Gas troenterol. 2006; 12 (48): 7725–7736. DOI: 10.3748/wjg.v12.i48.7725. PMID: 17203512Senzolo M., Burra P., Cholongitas E., Burroughs A.K. New insights into the coagulopathy of liver disease and liver transplantation. World J. Gastroenterol. 2006; 12 (48): 7725–7736. DOI: 10.3748/wjg.v12.i48.7725. PMID: 17203512Журавель С.В., Андрейцева О.И., Донова Л.В., Джаграев К.Р., Чжао А.В. Профилактика и лечение сосудистых осложнений после трансплантации печени. Трансплантология. 2012; 1-2: 33-37.Zhuravel S.V., Andreitseva O.I., Donova L.V., Dzhagraev K.R., Chzhao A.V. Prophylaxis end treatment of vascular complications after liver transplantation. Transplantologiya. 2012; 1-2: 33-37. [In Russ.]Bakker C.M., Metselaar H.J., Groenland T.N., Terpstra O.T., Stibbe J. Increased fibrinolysis in orthotopic but not in heterotopic liver transplantation: the role of the anhepatic phase. Transpl. Int. 1992; 5 (Suppl 1): S173-S174. DOI: 10.1007/978-3-642-77423-2_54. PMID: 14621767Bakker C.M., Metselaar H.J., Groenland T.N., Terpstra O.T., Stibbe J. Increased fibrinolysis in orthotopic but not in heterotopic liver transplantation: the role of the anhepatic phase. Transpl. Int. 1992; 5 (Suppl 1): S173-S174. DOI: 10.1007/978-3-642-77423-2_54. PMID: 14621767Bakker C.M., Metselaar H.J., Groenland T.N., Gomes M.J., Knot E.A., Hesselink E.J., Schalm S.W., Stibbe J., Terpstra O.T. Increased tissue-type plasminogen activator activity in orthotopic but not heterotopic liver transplantation: the role of the anhepatic period. Hepatology. 1992; 16 (2): 404-408. DOI: 10.1002/hep.1840160219. PMID: 1639350Bakker C.M., Metselaar H.J., Groenland T.N., Gomes M.J., Knot E.A., Hesselink E.J., Schalm S.W., Stibbe J., Terpstra O.T. Increased tissue-type plasminogen activator activity in orthotopic but not heterotopic liver transplantation: the role of the anhepatic period. Hepatology. 1992; 16 (2): 404-408. DOI: 10.1002/hep.1840160219. PMID: 1639350Azad S.C., Kratzer M.A., Groh J., Welte M., Haller M., Pratschke E. Intraoperative monitoring and postoperative reevaluation of hemostasis in orthotopic liver transplantation. Semin. Thromb. Hemost. 1993; 19 (3): 233-237. DOI: 10.1055/s-2007-994031. PMID: 8362253Azad S.C., Kratzer M.A., Groh J., Welte M., Haller M., Pratschke E. Intraoperative monitoring and postoperative reevaluation of hemostasis in orthotopic liver transplantation. Semin. Thromb. Hemost. 1993; 19 (3): 233-237. DOI: 10.1055/s-2007-994031. PMID: 8362253Paulsen A.W., Whitten C.W., Ramsay M.A., Klintmalm G.B. Considerations for anesthetic management during veno-venous bypassin adult hepatic transplantation. Anesth. Analg. 1989; 68 (4): 489-496. DOI: 10.1213/00000539-198904000-00012. PMID: 2648895Paulsen A.W., Whitten C.W., Ramsay M.A., Klintmalm G.B. Considerations for anesthetic management during veno-venous bypassin adult hepatic transplantation. Anesth. Analg. 1989; 68 (4): 489-496. DOI: 10.1213/00000539-198904000-00012. PMID: 2648895Scherer R., Giebler R., Erhard J., Lange R., Günnicker M., Schmutzler M., Paar D., Kox W.J. A new method of veno-venous bypass during human orthotopic liver transplantation. Anaesthesia. 1994; 49 (5): 398-402. DOI: 10.1111/j.1365-2044.1994.tb03471.x. PMID: 8209979Scherer R., Giebler R., Erhard J., Lange R., Günnicker M., Schmutzler M., Paar D., Kox W.J. A new method of veno-venous bypass during human orthotopic liver transplantation. Anaesthesia. 1994; 49 (5): 398-402. DOI: 10.1111/j.1365-2044.1994.tb03471.x. PMID: 8209979Shimauchi T., Yamaura K., Higashi M., Abe K., Yoshizumi T., Hoka S. Fibrinolysis in living donor liver transplantation recipients evaluated using thromboelastometry: impact on mortality. Transplant. Proc. 2017; 49 (9): 2117-2121. DOI: 10.1016/j.transproceed.2017.09.025. PMID: 29149971Shimauchi T., Yamaura K., Higashi M., Abe K., Yoshizumi T., Hoka S. Fibrinolysis in living donor liver transplantation recipients evaluated using thromboelastometry: impact on mortality. Transplant. Proc. 2017; 49 (9): 2117-2121. DOI: 10.1016/j.transproceed.2017.09.025. PMID: 29149971Bakker C.M., Blankensteijn J.D., Schlejen P., Porte R.J., Gomes M.J., Lampe H.I., Stibbe J., Terpstra O.T. The effects of long-term graft preservation on intraoperative hemostatic changes in liver transplantation. A comparison between orthotopic and heterotopic transplantation in the pig. HPB Surg. 1994; 7 (4): 265-280. DOI: 10.1155/1994/27915. PMID: 8204546Bakker C.M., Blankensteijn J.D., Schlejen P., Porte R.J., Gomes M.J., Lampe H.I., Stibbe J., Terpstra O.T. The effects of long-term graft preservation on intraoperative hemostatic changes in liver transplantation. A comparison between orthotopic and heterotopic transplantation in the pig. HPB Surg. 1994; 7 (4): 265-280. DOI: 10.1155/1994/27915. PMID: 8204546Wolberg A.S., Meng Z.H., Monroe D.M.3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J. Trauma. 2004; 56 (6): 1221–1228. DOI: 10.1097/01.TA.0000064328.97941.FC. PMID: 15211129Wolberg A.S., Meng Z.H., Monroe D.M.3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J. Trauma. 2004; 56 (6): 1221–1228. DOI: 10.1097/01.TA.0000064328.97941.FC. PMID: 15211129Martini W.Z. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. J. Trauma 2009; 67 (1): 202–208. DOI: 10.1097/TA.0b013e3181a602a7. PMID: 19590336Martini W.Z. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. J. Trauma 2009; 67 (1): 202–208. DOI: 10.1097/TA.0b013e3181a602a7. PMID: 19590336Han S.B., Gwak M.S., Choi S.J., Kim M.H., Ko J.S., Kim G.S., Joo H.S. Effect of active airway warming on body core temperature during adult liver transplantation. Transplant. Proc. 2013; 45(1): 251-254. DOI: 10.1016/j.transproceed.2012.05.088. PMID: 23375310Han S.B., Gwak M.S., Choi S.J., Kim M.H., Ko J.S., Kim G.S., Joo H.S. Effect of active airway warming on body core temperature during adult liver transplantation. Transplant. Proc. 2013; 45(1): 251-254. DOI: 10.1016/j.transproceed.2012.05.088. PMID: 23375310Ghadimi K., Levy J.H., Welsby I.J. Perioperative management of the bleeding patient. Br. J. Anaesth. 2016; 117 (Suppl 3): iii18-iii30. DOI: 10.1093/bja/aew358. PMID: 27940453Ghadimi K., Levy J.H., Welsby I.J. Perioperative management of the bleeding patient. Br. J. Anaesth. 2016; 117 (Suppl 3): iii18-iii30. DOI: 10.1093/bja/aew358. PMID: 27940453Reynolds L., Beckmann J., Kurz A. Perioperative complications of hypothermia. Best Pract. Res. Clin. Anaesthesiol. 2008; 22 (4): 645-657. DOI: 10.1016/j.bpa.2008.07.005. PMID: 19137808Reynolds L., Beckmann J., Kurz A. Perioperative complications of hypothermia. Best Pract. Res. Clin. Anaesthesiol. 2008; 22 (4): 645-657. DOI: 10.1016/j.bpa.2008.07.005. PMID: 19137808Pandey C.K., Singh A., Kajal K., Dhankhar M., Tandon M., Pandey V.K., Karna S.T. Intraoperative blood loss in orthotopic liver transplantation: the predictive factors. World J. Gastrointest. Surg. 2015; 7 (6): 86-93. DOI: 10.4240/wjgs.v7.i6.86. PMID: 26131330Pandey C.K., Singh A., Kajal K., Dhankhar M., Tandon M., Pandey V.K., Karna S.T. Intraoperative blood loss in orthotopic liver transplantation: the predictive factors. World J. Gastrointest. Surg. 2015; 7 (6): 86-93. DOI: 10.4240/wjgs.v7.i6.86. PMID: 26131330Senzolo M., Cholongitas E., Thalheimer U., Riddell A., Agarwal S., Mallett S., Ferronato C., Burroughs A.K. Heparin-like effect in liver disease and liver transplantation. Clin. Liver Dis. 2009; 13 (1): 43-53. DOI: 10.1016/j.cld.2008.09.004. PMID: 19150308Senzolo M., Cholongitas E., Thalheimer U., Riddell A., Agarwal S., Mallett S., Ferronato C., Burroughs A.K. Heparin-like effect in liver disease and liver transplantation. Clin. Liver Dis. 2009; 13 (1): 43-53. DOI: 10.1016/j.cld.2008.09.004. PMID: 19150308Tomescu D., Popescu M., Jipa L., Fota R., Ungureanu D., Zamfir R., Orban C., Dima S.O., Popescu I. The impact of donor liver graft quality on postoperative outcome in liver transplant recipients. A single centre experience. Rom. J. Anaesth. Intensive Care. 2016; 23 (1): 19-26. DOI: 10.21454/rjaic.7518.231.gft. PMID: 28913473Tomescu D., Popescu M., Jipa L., Fota R., Ungureanu D., Zamfir R., Orban C., Dima S.O., Popescu I. The impact of donor liver graft quality on postoperative outcome in liver transplant recipients. A single centre experience. Rom. J. Anaesth. Intensive Care. 2016; 23 (1): 19-26. DOI: 10.21454/rjaic.7518.231.gft. PMID: 28913473Moriau M., Kestens P.J., Masure R. Heparin and antifibrinolytic agents during experimental hepatectomy and liver transplantation. Pathol. Eur. 1969; 4 (2): 172–182. PMID: 4896202Moriau M., Kestens P.J., Masure R. Heparin and antifibrinolytic agents during experimental hepatectomy and liver transplantation. Pathol. Eur. 1969; 4 (2): 172–182. PMID: 4896202Porte R.J., Bontempo F.A., Knot E.A., Lewis J.H., Kang Y.G., Starzl T.E. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation. 1989; 47 (6): 978-984. DOI: 10.1097/00007890198906000-00012. PMID: 2499962Porte R.J., Bontempo F.A., Knot E.A., Lewis J.H., Kang Y.G., Starzl T.E. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation. 1989; 47 (6): 978-984. DOI: 10.1097/00007890198906000-00012. PMID: 2499962Hutchison D.E., Genton E., Porter K.A., Daloze P.M., Huguet C., Brettschneider L., Groth C.G., Starzl T.E. Platelet changes following clinical and experimental hepatic homotransplantation. Arch. Surg. 1968; 97 (1): 27–33. DOI: 10.1001/archsurg.1968.01340010057003. PMID: 4232038Hutchison D.E., Genton E., Porter K.A., Daloze P.M., Huguet C., Brettschneider L., Groth C.G., Starzl T.E. Platelet changes following clinical and experimental hepatic homotransplantation. Arch. Surg. 1968; 97 (1): 27–33. DOI: 10.1001/archsurg.1968.01340010057003. PMID: 4232038Reuvers C.B., Terpstra O.T., Groenland T.H., Boks A.L., Faithfull N.S., ten Kate F.W. Hemodynamics and coagulation in experimental auxiliary liver transplantation during fulminant hepatic failure. Ann. Surg. 1986; 204 (5): 552-558. DOI: 10.1097/00000658-198611000-00008. PMID: 3532973Reuvers C.B., Terpstra O.T., Groenland T.H., Boks A.L., Faithfull N.S., ten Kate F.W. Hemodynamics and coagulation in experimental auxiliary liver transplantation during fulminant hepatic failure. Ann. Surg. 1986; 204 (5): 552-558. DOI: 10.1097/00000658-198611000-00008. PMID: 3532973Kang Y., Audu P. Coagulation and liver transplantation. Int. Anesthesiol. Clin. 2006; 44 (4): 17-36. DOI: 10.1097/01.aia.0000210811.77663.1e. PMID: 17033477Kang Y., Audu P. Coagulation and liver transplantation. Int. Anesthesiol. Clin. 2006; 44 (4): 17-36. DOI: 10.1097/01.aia.0000210811.77663.1e. PMID: 17033477Шумаков В.И. (ред.). Трансплантология. М.: МИА; 2006: 310-330. ISBN: 5-89481-453-7Shumakov V.I. (ed.). Transplantation. Moscow: Meditsinskoe Informatsionnoe Agentstvo, 2006: 310-330. ISBN: 5-89481-453-7 [In Russ.]Schrem H., Klußmann A., Focken M., Emmanouilidis N., Oldhafer F., Klempnauer J., Kaltenborn A. Post-operative hemorrhage after liver transplantation: risk factors and long-term outcome. Ann. Transplant. 2016; 21: 46-55. DOI: 10.12659/AOT.895605. PMID: 26818716Schrem H., Klußmann A., Focken M., Emmanouilidis N., Oldhafer F., Klempnauer J., Kaltenborn A. Post-operative hemorrhage after liver transplantation: risk factors and long-term outcome. Ann. Transplant. 2016; 21: 46-55. DOI: 10.12659/AOT.895605. PMID: 26818716Yuki K., Bu W., Shimaoka M., Eckenhoff R. Volatileanesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. PLoSOne. 2013; 8 (4): e60415. DOI: 10.1371/journal.pone.0060415. PMID: 23573252Yuki K., Bu W., Shimaoka M., Eckenhoff R. Volatileanesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. PLoSOne. 2013; 8 (4): e60415. DOI: 10.1371/journal.pone.0060415. PMID: 23573252Faraday N. Platelets, perioperative hemostasis, and anesthesia. Anesthesiology. 2002; 96 (5): 1042-1043. DOI: 10.1097/00000542-20020500000003. PMID: 11981140Faraday N. Platelets, perioperative hemostasis, and anesthesia. Anesthesiology. 2002; 96 (5): 1042-1043. DOI: 10.1097/00000542-20020500000003. PMID: 11981140Ueda I. The effects of volatile general anesthetics on adenosine diphosphateinduced platelet aggregation. Anesthesiology. 1971; 34 (5): 405408. DOI: 10.1097/00000542-197105000-00006. PMID: 5554584Ueda I. The effects of volatile general anesthetics on adenosine diphosphateinduced platelet aggregation. Anesthesiology. 1971; 34 (5): 405408. DOI: 10.1097/00000542-197105000-00006. PMID: 5554584Журавель С.В., Чугунов А.О., Салиенко А.А., Донова Л.В. Трансплантация печени, осложненная острым тромбозом воротной вены. Вестн. интенс. терапии. 2009; 3: 70-72.Zhuravel S.V., Chugunov A.O., Salienko A.A., Donova L.V. Liver transplantation complicated by acute portal vein thrombosis. Vestnik Intensivnoi Terapii. 2009; 3: 70-72. [In Russ.]Abuelkasem E., Lu S., Tanaka K., Planinsic R., Sakai T. Comparison between thrombelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation..Br. J. Anaesth. 2016; 116 (4): 507-512. DOI: 10.1093/bja/aew023. PMID: 26934942Abuelkasem E., Lu S., Tanaka K., Planinsic R., Sakai T. Comparison between thrombelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation..Br. J. Anaesth. 2016; 116 (4): 507-512. DOI: 10.1093/bja/aew023. PMID: 26934942Ozier Y., Pessione F., Samain E., Courtois F.; French Study Group on Blood Transfusion in Liver Transplantation. Institutional variability in transfusion practice for liver transplantation. Anesth. Analg. 2003; 97 (3): 671– 679. DOI: 10.1213/01.ANE.0000073354.38695.7C. PMID: 12933381Ozier Y., Pessione F., Samain E., Courtois F.; French Study Group on Blood Transfusion in Liver Transplantation. Institutional variability in transfusion practice for liver transplantation. Anesth. Analg. 2003; 97 (3): 671– 679. DOI: 10.1213/01.ANE.0000073354.38695.7C. PMID: 12933381Hutten B.A., Lensing A.W., Kraaijenhagen R.A., Prins M.H. Safety of treatment with oral anticoagulants in the elderly. A systematic review. Drugs Aging. 1999; 14 (4): 303-312. DOI: 10.2165/00002512-19991404000005. PMID: 10319243Hutten B.A., Lensing A.W., Kraaijenhagen R.A., Prins M.H. Safety of treatment with oral anticoagulants in the elderly. A systematic review. Drugs Aging. 1999; 14 (4): 303-312. DOI: 10.2165/00002512-19991404000005. PMID: 10319243Anand S.S., Bates S., Ginsberg J.S., Levine M., Buller H., Prins M., Haley S., Kearon C., Hirsh J., Gent M. Reccurent venous thrombsis and heparin therapy: an evaluation of the importance of early activated partial tromboplastin times. Arch. Intern. Med. 1999; 159 (17): 2029-2032. DOI: 10.1001/archinte.159.17.2029. PMID: 10510988Anand S.S., Bates S., Ginsberg J.S., Levine M., Buller H., Prins M., Haley S., Kearon C., Hirsh J., Gent M. Reccurent venous thrombsis and heparin therapy: an evaluation of the importance of early activated partial tromboplastin times. Arch. Intern. Med. 1999; 159 (17): 2029-2032. DOI: 10.1001/archinte.159.17.2029. PMID: 10510988Algarni A.A., Mourad M.M., Bramhall S.R. Anticoagulation and antiplatelets as prophylaxis for hepatic artery thrombosis after liver transplantation. World J. Hepatol. 2015; 7 (9): 1238-1243. DOI: 10.4254/wjh.v7.i9.1238. PMID: 26019738Algarni A.A., Mourad M.M., Bramhall S.R. Anticoagulation and antiplatelets as prophylaxis for hepatic artery thrombosis after liver transplantation. World J. Hepatol. 2015; 7 (9): 1238-1243. DOI: 10.4254/wjh.v7.i9.1238. PMID: 26019738Wall W.J., Grant D.R., Duff J.H., Kutt J.L., Ghent C.N. Blood transfusion requirements and renal function in patient undergoing liver transplantation without venous bypass. Transplant. Proc. 1987; 19 (4 Suppl 3): 1720. PMID: 3303529Wall W.J., Grant D.R., Duff J.H., Kutt J.L., Ghent C.N. Blood transfusion requirements and renal function in patient undergoing liver transplantation without venous bypass. Transplant. Proc. 1987; 19 (4 Suppl 3): 1720. PMID: 3303529de Boer M.T., Molenaar I.Q., Hendriks H.G., Slooff M.J., Porte R.J. Minimizing blood loss in liver transplantation: progress through research and evolution of techniques. Dig. Surg. 2005; 22 (4): 265-275. DOI: 10.1159/000088056. PMID: 16174983de Boer M.T., Molenaar I.Q., Hendriks H.G., Slooff M.J., Porte R.J. Minimizing blood loss in liver transplantation: progress through research and evolution of techniques. Dig. Surg. 2005; 22 (4): 265-275. DOI: 10.1159/000088056. PMID: 16174983de Boer M.T., Christensen M.C., Asmussen M., van der Hilst C.S., Hendriks H.G., Slooff M.J., Porte R.J. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth. Analg. 2008; 106 (1): 32–44. DOI: 10.1213/01.ane.0000289638. 26666.ed. PMID: 18165548de Boer M.T., Christensen M.C., Asmussen M., van der Hilst C.S., Hendriks H.G., Slooff M.J., Porte R.J. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth. Analg. 2008; 106 (1): 32–44. DOI: 10.1213/01.ane.0000289638. 26666.ed. PMID: 18165548Cap A.P., Spinella P.C., Borgman M.A., Blackbourne L.H., Perkins J.G. Timing and location of blood product transfusion and outcomes in massively transfused combat casualties. J. Trauma Acute Care Surg. 2012; 73 (2 Suppl 1): S89–S94. DOI: 10.1097/TA.0b013e318260625a. PMID: 22847102Cap A.P., Spinella P.C., Borgman M.A., Blackbourne L.H., Perkins J.G. Timing and location of blood product transfusion and outcomes in massively transfused combat casualties. J. Trauma Acute Care Surg. 2012; 73 (2 Suppl 1): S89–S94. DOI: 10.1097/TA.0b013e318260625a. PMID: 22847102Phillips S.D., Maguire D., Deshpande R., Muiesan P., Bowles M.J., Rela M., Heaton N.D. A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation. Transplantation. 2006; 81 (4): 536–540. DOI: 10.1097/01.tp.0000199318.17013.c5. PMID: 16495800Phillips S.D., Maguire D., Deshpande R., Muiesan P., Bowles M.J., Rela M., Heaton N.D. A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation. Transplantation. 2006; 81 (4): 536–540. DOI: 10.1097/01.tp.0000199318.17013.c5. PMID: 16495800Massicotte L., Thibeault L., Beaulieu D., Roy J.D., Roy A. Evaluation of cell salvage autotransfusion utility during liver transplantation. HPB (Oxford). 2007; 9 (1): 52–57. DOI: 10.1080/13651820601090596. PMID: 18333113Massicotte L., Thibeault L., Beaulieu D., Roy J.D., Roy A. Evaluation of cell salvage autotransfusion utility during liver transplantation. HPB (Oxford). 2007; 9 (1): 52–57. DOI: 10.1080/13651820601090596. PMID: 18333113Massicotte L., Thibeault L., Roy A. Classical notions of coagulation revisited in relation with blood losses, transfusion rate for 700 consecutive liver transplantations. Semin. Thromb. Hemost. 2015; 41 (5): 538-546. DOI: 10.1055/s-0035-1550428. PMID: 26080304Massicotte L., Thibeault L., Roy A. Classical notions of coagulation revisited in relation with blood losses, transfusion rate for 700 consecutive liver transplantations. Semin. Thromb. Hemost. 2015; 41 (5): 538-546. DOI: 10.1055/s-0035-1550428. PMID: 26080304Kırnap M., Tezcaner T., Ayvazogl˘u Soy H.E., Akdur A., Yildirim S., Torgay A., Moray G., Haberal M. Efficacy of cell saver use in living-donor liver transplant. Exp. Clin. Transplant. 2015; 13 (Suppl 1): 315–317. DOI: 10.6002/ect.mesot2014.P153. PMID: 25894181Kırnap M., Tezcaner T., Ayvazogl˘u Soy H.E., Akdur A., Yildirim S., Torgay A., Moray G., Haberal M. Efficacy of cell saver use in living-donor liver transplant. Exp. Clin. Transplant. 2015; 13 (Suppl 1): 315–317. DOI: 10.6002/ect.mesot2014.P153. PMID: 25894181Liang T.B., Li D.L., Liang L., Li J.J., Bai X.L., Yu W., Wang W.L., Shen Y., Zhang M., Zheng S.S. Intraoperative blood salvage during liver transplan tation in patients with hepatocellular carcinoma: efficiency of leukocyte depletion filters in the removal of tumor cells. Transplantation. 2008; 85 (6): 863-869. DOI: 10.1097/TP.0b013e3181671f2e. PMID: 18360269Liang T.B., Li D.L., Liang L., Li J.J., Bai X.L., Yu W., Wang W.L., Shen Y., Zhang M., Zheng S.S. Intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: efficiency of leukocyte depletion filters in the removal of tumor cells. Transplantation. 2008; 85 (6): 863-869. DOI: 10.1097/TP.0b013e3181671f2e. PMID: 18360269Araujo R.L., Pantanali C.A., Haddad L., Rocha Filho J.A., D’Albuquerque L.A., Andraus W. Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence? World J. Gastrointest. Surg. 2016; 8 (2): 161-168. DOI: 10.4240/wjgs.v8.i2.161. PMID: 26981190Araujo R.L., Pantanali C.A., Haddad L., Rocha Filho J.A., D’Albuquerque L.A., Andraus W. Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence? World J. Gastrointest. Surg. 2016; 8 (2): 161-168. DOI: 10.4240/wjgs.v8.i2.161. PMID: 26981190Freire M.P., Soares Oshiro I.C., Bonazzi P.R., Guimarães T., Ramos Figueira E.R., Bacchella T., Costa S.F., Carneiro D’Albuquerque L.A., Abdala E. Surgical site infections in liver transplant recipients in the model for endstage liver disease era: an analysis of the epidemiology, risk factors, and outcomes. Liver Transpl. 2013; 19 (9): 1011–1019. DOI: 10.1002/lt.23682. PMID: 23744748Freire M.P., Soares Oshiro I.C., Bonazzi P.R., Guimarães T., Ramos Figueira E.R., Bacchella T., Costa S.F., Carneiro D’Albuquerque L.A., Abdala E. Surgical site infections in liver transplant recipients in the model for endstage liver disease era: an analysis of the epidemiology, risk factors, and outcomes. Liver Transpl. 2013; 19 (9): 1011–1019. DOI: 10.1002/lt.23682. PMID: 23744748Reichert B., Kaltenborn A., Becker T., Schiffer M., Klempnauer J., Schrem H. Massive blood transfusion after the first cut in liver transplantation predicts renal outcome and survival. Langenbecks Arch. Surg. 2014; 399 (4): 429–440. DOI: 10.1007/s00423-014-1181-y. PMID: 24682384Reichert B., Kaltenborn A., Becker T., Schiffer M., Klempnauer J., Schrem H. Massive blood transfusion after the first cut in liver transplantation predicts renal outcome and survival. Langenbecks Arch. Surg. 2014; 399 (4): 429–440. DOI: 10.1007/s00423-014-1181-y. PMID: 24682384Мороз В.В., Черныш А.М., Козлова Е.К., Сергунова В.А., Гудкова О.Е., Хорошилов С.Е., Онуфриевич А.Д., Костин А.И. Нарушения морфологии и наноструктуры мембран эритроцитов при длительном хранении эритроцитарной взвеси (исследование при помощи атомной силовой микроскопии). Бюл. эксперим. биологии и медицины. 2015; 159 (3): 390-394. DOI: 10.1007/s10517-015-2975-9. PMID: 26212816Moroz V.V., Chernysh A.M., Kozlova E.K., Sergunova V.A., Gudkova O.E., Khoroshilov S.E., Onufrievich A.D., Kostin A.I. Disorders in the morphology and nanostructure of erythrocyte membranes after long-term storage of erythrocyte suspension: atomic force microscopy study. Byulleten Experimentalnoi Biologii i Meditsiny. 2015; 159 (3): 406-410. DOI: 10.1007/s10517-015-2975-9. PMID: 26212816. [In Russ., In Engl.]Kozlova E., Chernysh A., Moroz V., Sergunova V., Gudkova O., Manchenko E. Morphology, membrane nanostructure and stiffness for quality assessment of packed red blood cells. Sci. Rep. 2017; 7 (1): 7846. DOI: 1038/s41598-017-08255-9. PMID: 28798476Kozlova E., Chernysh A., Moroz V., Sergunova V., Gudkova O., Manchenko E. Morphology, membrane nanostructure and stiffness for quality assessment of packed red blood cells. Sci. Rep. 2017; 7 (1): 7846. DOI: 1038/s41598-017-08255-9. PMID: 28798476Сергунова В.А., Гудкова О.Е., Манченко Е.А., Козлова Е.К., Бобринская И.Г., Черныш А.М., Козлов А.П. Влияние температуры эритроцитарной взвеси на морфологию и наноструктуру мембран клеток. Общая реаниматология. 2017; 13 (4): 30-37. DOI: 10.15360/1813-9779-20174-30-37Sergunova V.A., Gudkova O.E., Manchenko E.A., Kozlova E.K., Bobrinskaya I.G., Chernysh A.M., Kozlov A.P. The effect of the erythrocyte suspension temperature on the morphology and nanostructure of cell membranes. Obshchaya Reanimatologiya = General Reanimatology. 2017; 13 (4): 3037. DOI: 10.15360/1813-9779-2017-4-30-37. [In Russ., In Engl.]Wang S.C., Shieh J.F., Chang K.Y., Chu Y.C., Liu C.S., Loong C.C., Chan K.H., Mandell S., Tsou M.Y. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant. Proc. 2010; 42 (7): 2590–2593. DOI: 10.1016/j.transproceed.2010.05.144. PMID: 20832550Wang S.C., Shieh J.F., Chang K.Y., Chu Y.C., Liu C.S., Loong C.C., Chan K.H., Mandell S., Tsou M.Y. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant. Proc. 2010; 42 (7): 2590–2593. DOI: 10.1016/j.transproceed.2010.05.144. PMID: 20832550Hendriks H.G., Meijer K., de Wolf J.T., Klompmaker I.J., Porte R.J., de Kam P.J., Hagenaars A.J., Melsen T., Slooff M.J., van der Meer J. Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study. Transplantation. 2001; 71 (3): 402-405. DOI: 10.1097/00007890-200102150-00011. PMID: 11233901Hendriks H.G., Meijer K., de Wolf J.T., Klompmaker I.J., Porte R.J., de Kam P.J., Hagenaars A.J., Melsen T., Slooff M.J., van der Meer J. Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study. Transplantation. 2001; 71 (3): 402-405. DOI: 10.1097/00007890-200102150-00011. PMID: 11233901Pugliese F., Ruberto F., Summonti D., Perrella S., Cappannoli A., Tosi A., D’alio A., Bruno K., Martelli S., Celli P., Morabito V., Rossi M., Berloco P.B, Pietropaoli P. Activated recombinant factor VII in orthotopic liver transplantation. Transplant. Proc. 2007; 39 (6): 1883-1885. DOI: 10.1016/j.transproceed.2007.05.062. PMID: 17692642Pugliese F., Ruberto F., Summonti D., Perrella S., Cappannoli A., Tosi A., D’alio A., Bruno K., Martelli S., Celli P., Morabito V., Rossi M., Berloco P.B, Pietropaoli P. Activated recombinant factor VII in orthotopic liver transplantation. Transplant. Proc. 2007; 39 (6): 1883-1885. DOI: 10.1016/j.transproceed.2007.05.062. PMID: 17692642Chavez-Tapia N.C., Alfaro-Lara R., Tellez-Avila F., Barrientos-Gutiérrez T., González-Chon O., Mendez-Sanchez N., Uribe M. Prophylactic activated recombinant factor VII in liver resection and liver transplantation: systematic review and meta-analysis. PLoS One. 2011; 6 (7): e22581. DOI: 10.1371/journal.pone.0022581. PMID: 21818342Chavez-Tapia N.C., Alfaro-Lara R., Tellez-Avila F., Barrientos-Gutiérrez T., González-Chon O., Mendez-Sanchez N., Uribe M. Prophylactic activated recombinant factor VII in liver resection and liver transplantation: systematic review and meta-analysis. PLoS One. 2011; 6 (7): e22581. DOI: 10.1371/journal.pone.0022581. PMID: 21818342Scheffert J.L., Taber D.J., Pilch N.A., McGillicuddy J.W., Baliga P.K., Chavin K.D. Timing of factor VIIa in liver transplantation impacts cost and clinical outcomes. Pharmacotherapy. 2013; 33 (5): 483-488. DOI: 10.1002/phar.1230. PMID: 23468226Scheffert J.L., Taber D.J., Pilch N.A., McGillicuddy J.W., Baliga P.K., Chavin K.D. Timing of factor VIIa in liver transplantation impacts cost and clinical outcomes. Pharmacotherapy. 2013; 33 (5): 483-488. DOI: 10.1002/phar.1230. PMID: 23468226Helfritz F.A., Stiefel P., Manns M.P., Klempnauer J., Lehner F., Lenzen H., Ciesek S. Use of recombinant factor VIIA as a risk factor for graft loss after orthotopic liver transplantation due to hepatic artery thrombosis. J. Bioequiv. Availab. 2016; 8: 8-12. DOI: 10.4172/jbb.1000259Helfritz F.A., Stiefel P., Manns M.P., Klempnauer J., Lehner F., Lenzen H., Ciesek S. Use of recombinant factor VIIA as a risk factor for graft loss after orthotopic liver transplantation due to hepatic artery thrombosis. J. Bioequiv. Availab. 2016; 8: 8-12. DOI: 10.4172/jbb.1000259Trzebicki J., Flakiewicz E., Kosieradzki M., Blaszczyk B., Kołacz M., Jureczko L., Pacholczyk M., Chmura A., Lagiewska B., Lisik W., Wasiak D., Kosson D., Kwiatkowski A., Lazowski T. The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products. Ann. Transplant. 2010; 15 (3): 19–24. PMID: 20877262Trzebicki J., Flakiewicz E., Kosieradzki M., Blaszczyk B., Kołacz M., Jureczko L., Pacholczyk M., Chmura A., Lagiewska B., Lisik W., Wasiak D., Kosson D., Kwiatkowski A., Lazowski T. The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products. Ann. Transplant. 2010; 15 (3): 19–24. PMID: 20877262Molenaar I.Q., Warnaar N., Groen H., Tenvergert E.M., Slooff M.J., Porte R.J. Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis. Am. J. Transplant. 2007; 7 (1): 185–194. DOI: 10.1111/j.1600-6143.2006.01591.x. PMID: 17227567Molenaar I.Q., Warnaar N., Groen H., Tenvergert E.M., Slooff M.J., Porte R.J. Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis. Am. J. Transplant. 2007; 7 (1): 185–194. DOI: 10.1111/j.1600-6143.2006.01591.x. PMID: 17227567Kozek-Langenecker S.A., Afshari A., Albaladejo P., Santullano C.A., De Robertis E., Filipescu D.C., Fries D., Görlinger K., Haas T., Imberger G., Jacob M., Lancé M., Llau J., Mallett S., Meier J., Rahe-Meyer N., Samama C.M., Smith A., Solomon C., Van der Linden P., Wikkelsø A.J., Wouters P., Wyffels P. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur. J. Anaesthesiol. 2013; 30 (6): 270–382. DOI: 10.1097/EJA.0b013e32835f4d5b. PMID: 23656742Kozek-Langenecker S.A., Afshari A., Albaladejo P., Santullano C.A., De Robertis E., Filipescu D.C., Fries D., Görlinger K., Haas T., Imberger G., Jacob M., Lancé M., Llau J., Mallett S., Meier J., Rahe-Meyer N., Samama C.M., Smith A., Solomon C., Van der Linden P., Wikkelsø A.J., Wouters P., Wyffels P. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur. J. Anaesthesiol. 2013; 30 (6): 270–382. DOI: 10.1097/EJA.0b013e32835f4d5b. PMID: 23656742Ogren M., Bergqvist D., Björck M., Acosta S., Eriksson H., Sternby N.H. Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J. Gastroenterol. 2006; 12 (13): 2115-2119. DOI: 10.3748/wjg.v12.i13.2115. PMID: 16610067Ogren M., Bergqvist D., Björck M., Acosta S., Eriksson H., Sternby N.H. Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J. Gastroenterol. 2006; 12 (13): 2115-2119. DOI: 10.3748/wjg.v12.i13.2115. PMID: 16610067Хорошилов С.Е., Никулин А.В. Детоксикация при критических состояниях: понимание научной проблемы в XXI веке (обзор). Общая реаниматология. 2017; 13 (5): 85-108. DOI: 10.15360/18139779-2017-5-85-108Khoroshilov S.E., Nikulin A.V. Detoxication in critical conditions: an insight into the scientific problem in the XXI century (review). Obshchaya Reanimatologiya = General Reanimatology. 2017; 13 (5): 85-108. DOI: 10.15360/1813-9779-2017-5-85-108. [In Russ., In Engl.]Trzebicki J., Kosieradzki M., Flakiewicz E., Kuzminska G., Wasiak D., Pacholczyk M., Lagiewska B., Lisik W., Kosson D., Kulik A., Chmura A., Lazowski T. Detrimental effect of aprotinin ban on amount of blood loss during liver transplantation: single-center experience. Transplant. Proc. 2011; 43 (5): 1725–1727. DOI: 10.1016/j.transproceed.2011.01.182. PMID: 21693266Trzebicki J., Kosieradzki M., Flakiewicz E., Kuzminska G., Wasiak D., Pacholczyk M., Lagiewska B., Lisik W., Kosson D., Kulik A., Chmura A., Lazowski T. Detrimental effect of aprotinin ban on amount of blood loss during liver transplantation: single-center experience. Transplant. Proc. 2011; 43 (5): 1725–1727. DOI: 10.1016/j.transproceed.2011.01.182. PMID: 21693266Schofield N., Sugavanam A., Thompson K., Mallett S.V. No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin. Liver Transpl. 2014; 20 (5): 584–590. DOI: 10.1002/lt.23839. PMID: 24481770Schofield N., Sugavanam A., Thompson K., Mallett S.V. No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin. Liver Transpl. 2014; 20 (5): 584–590. DOI: 10.1002/lt.23839. PMID: 24481770Massicotte L., Lenis S., Thibeault L., Sassine M.P., Seal R.F., Roy A. Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantations. Liver Transpl. 2006; 12 (1): 117-123. DOI: 10.1002/lt.20559. PMID: 16382461Massicotte L., Lenis S., Thibeault L., Sassine M.P., Seal R.F., Roy A. Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantations. Liver Transpl. 2006; 12 (1): 117-123. DOI: 10.1002/lt.20559. PMID: 16382461Massicotte L., Beaulieu D., Thibeault L., Roy J.D., Marleau D., Lapointe R., Roy A. Coagulation defects do not predict blood product requirements during liver transplantation. Transplantation 2008; 85 (7): 956962. DOI: 10.1097/TP.0b013e318168fcd4. PMID: 18408574Massicotte L., Beaulieu D., Thibeault L., Roy J.D., Marleau D., Lapointe R., Roy A. Coagulation defects do not predict blood product requirements during liver transplantation. Transplantation 2008; 85 (7): 956962. DOI: 10.1097/TP.0b013e318168fcd4. PMID: 18408574Schroeder R.A., Collins B.H., Tuttle-Newhall E., Robertson K., Plotkin J., Johnson L.B., Kuo P.C. Intraoperative fluid management during orthotopic liver transplantation. J. Cardiothorac. Vasc. Anesth. 2004; 18 (4): 438–441. DOI: 10.1053/j.jvca.2004.05.020. PMID: 15365923Schroeder R.A., Collins B.H., Tuttle-Newhall E., Robertson K., Plotkin J., Johnson L.B., Kuo P.C. Intraoperative fluid management during orthotopic liver transplantation. J. Cardiothorac. Vasc. Anesth. 2004; 18 (4): 438–441. DOI: 10.1053/j.jvca.2004.05.020. PMID: 15365923Colomina M.J., Díez Lobo A., Garutti I., Gómez-Luque A., Llau J.V., Pita E. Perioperative use of prothrombin complex concentrates. Minerva Anestesiol. 2012; 78: 358-368. PMID: 22357373Colomina M.J., Díez Lobo A., Garutti I., Gómez-Luque A., Llau J.V., Pita E. Perioperative use of prothrombin complex concentrates. Minerva Anestesiol. 2012; 78: 358-368. PMID: 22357373Arshad F., Ickx B., van Beem R.T., Polak W., Grüne F., Nevens F., Ilmakunnas M., Koivusalo A.M., Isoniemi H., Strengers P.F., Groen H., Hendriks H.G., Lisman T., Pirenne J., Porte R.J. Prothrombin complex concentrate in the reduction of blood loss during orthotopicliver transplantation: PROTON-trial. BMC Surg. 2013; 13: 22. DOI: 0.1186/1471-2482-1322. PMID: 23815798Arshad F., Ickx B., van Beem R.T., Polak W., Grüne F., Nevens F., Ilmakunnas M., Koivusalo A.M., Isoniemi H., Strengers P.F., Groen H., Hendriks H.G., Lisman T., Pirenne J., Porte R.J. Prothrombin complex concentrate in the reduction of blood loss during orthotopicliver transplantation: PROTON-trial. BMC Surg. 2013; 13: 22. DOI: 0.1186/1471-2482-1322. PMID: 23815798Quintero J., Ortega J., Miserachs M., Bueno J., Bilbao I., Charco R. Low plasma levels of antithrombin III in the early post-operative period following pediatric liver transplantation: should they be replaced? A singlecenter pilot study. Pediatr. Transplant. 2014; 18 (2): 185-189. DOI: 10.1111/petr.12217. PMID: 24438318Quintero J., Ortega J., Miserachs M., Bueno J., Bilbao I., Charco R. Low plasma levels of antithrombin III in the early post-operative period following pediatric liver transplantation: should they be replaced? A singlecenter pilot study. Pediatr. Transplant. 2014; 18 (2): 185-189. DOI: 10.1111/petr.12217. PMID: 24438318Allingstrup M., Wetterslev J., Ravn F.B., Møller A.M., Afshari A. Antithrombin III for critically ill patients. Cochrane Database Syst. Rev. 2016; 2: CD005370. DOI: 10.1002/14651858.CD005370.pub3. PMID: 26858174Allingstrup M., Wetterslev J., Ravn F.B., Møller A.M., Afshari A. Antithrombin III for critically ill patients. Cochrane Database Syst. Rev. 2016; 2: CD005370. DOI: 10.1002/14651858.CD005370.pub3. PMID: 26858174

The authors declare that there are no conflicts of interest present.