rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2018-5-85-95rmt-1715Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSНарушения системы гемостаза у пациентов в остром периоде изолированной черепно-мозговой травмы (обзор)Hemostasis Disturbances in Patients in the Acute Period of Isolated Traumatic Brain Injury (Review)БараничА. И.BaranichA. I.

Анастасия Баранич

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Anastasia I. Baranich

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

anastasia.baranich@gmail.comСычевА. А.SychevA. A.

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Aleksandr A. Sychev

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

СавинИ. А.SavinI. А.

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Ivan A. Savin

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

ПолупанА. А.PolupanA. A.

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Aleksandr A. Polupan

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

ОшоровА. В.OshorovA. V.

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Andrei V. Oshorov

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

ПотаповА. А.PotapovA. A.

125047, Москва, 4-я Тверская-Ямская ул., д. 16 

Aleksandr A. Potapov

16 Tverskaya-Yamskaya 4th Str., 125047, Moscow

Национальный медицинский исследовательский центр нейрохирургии им. Н. Н. Бурденко Минздрава России РоссияРоссияN. N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Health of RussiaRussian Federation2018281020181458595Copyright © Баранич А.И., Сычев А.А., Савин И.А., Полупан А.А., Ошоров А.В., Потапов А.А., 20182018Баранич А.И., Сычев А.А., Савин И.А., Полупан А.А., Ошоров А.В., Потапов А.А.Baranich A.I., Sychev A.A., Savin I.А., Polupan A.A., Oshorov A.V., Potapov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1715

Острая изолированная черепно-мозговая травма (ЧМТ) часто связана с возникновением нарушений системы гемостаза, что может сопровождаться геморрагическими и ишемическими проявлениями в веществе головного мозга, в связи с чем нормальное функционирование свертывающей системы крови имеет критическое значение. Понимание патофизиологических механизмов данного явления может помочь адекватной профилактике вторичного повреждения головного мозга. Ранее, развитие синдрома диссеминированного внутрисосудистого свертывания (ДВС-синдрома) являлось общепринятой гипотезой механизма нарушений свертывающей системы при ЧМТ. Однако, за последние десятилетия появлялись новые данные о ключевой роли тканевого фактора, системного воспалительного ответа, тромбоцитопатии, эффекта протеина C в возникновении данной коагулопатии. Целью данного обзора литературы являлся предоставление новых данных о конкретных патофизиологических механизмах, лежащих в основе коагулопатии после ЧМТ.

Acute isolated traumatic brain injury (TBI) is frequently associated with occurrence of hemostasis disorders, which may be accompanied with hemorrhagic and ischemic events in the brain matter, hence, normal functioning of the blood coagulation system is critical. Understanding of the pathophysiological mechanisms of this phenomenon might help adequate prophylaxis of secondary brain damage. Earlier, development of disseminated intravascular coagulation syndrome (DIC) has been generally considered as a mechanism of coagulation disorders during TBI. However, over the recent decades, new data emerged concerning the key role of tissue factor, systemic inflammation response, thrombocytopathy, protein C effect in the occurrence of this coagulopathy. This overview of literature is aimed at providing the new data on specific pathophysiological mechanisms underlying coagulopathy following TBI.

ЧМТ-ассоциированная коагулопатияЧМТчерепно-мозговая травмагемостазкоагулопатиягеморрагические очагиишемические очагитромбоцитопатиямикротромбымикровезикулытканевой факторнейрохирургияTBI-associated coagulopathyTBItraumatic brain injuryhemostasiscoagulopathyhemorrhagic fociischemic fociplatelet disfunctionmicrothrombsmicrovesiclestissue factorneurosurgeryReferencesStein S.C., Chen X.H., Sinson G.P., Smith D.H. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J. Neurosurg. 2002; 97 (6): 1373-1377. DOI: 10.3171/jns.2002.97.6.1373. PMID: 12507136Stein S.C., Chen X.H., Sinson G.P., Smith D.H. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J. Neurosurg. 2002; 97 (6): 1373-1377. DOI: 10.3171/jns.2002.97.6.1373. PMID: 12507136Stein S.C., Young G.S., Talucci R.C., Greenbaum B.H., Ross S.E. Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery. 1992; 30 (2): 160-165. DOI: 10.1097/00006123-199202000-00002. PMID: 1545882Stein S.C., Young G.S., Talucci R.C., Greenbaum B.H., Ross S.E. Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery. 1992; 30 (2): 160-165. DOI: 10.1097/00006123-199202000-00002. PMID: 1545882Stein S.C., Spettell C., Young G., Ross S.E. Delayed and progressive brain injury in closed-head trauma: radiological demonstration. Neurosurgery. 1993; 32 (1): 25-30. DOI: 10.1097/00006123-199301000-00004. PMID: 8421553Stein S.C., Spettell C., Young G., Ross S.E. Delayed and progressive brain injury in closed-head trauma: radiological demonstration. Neurosurgery. 1993; 32 (1): 25-30. DOI: 10.1097/00006123-199301000-00004. PMID: 8421553Juratli T.A., Zang B., Litz R.J., Sitoci K.H., Aschenbrenner U., Gottschlich B., Daubner D., Schackert G., Sobottka S.B. Early hemorrhagic progression of traumatic brain contusions: frequency, correlation with coagulation disorders, and patient outcome: a prospective study. J. Neurotrauma. 2014; 31 (17): 1521-1527. DOI: 10.1089/neu.2013.3241. PMID: 24738836Juratli T.A., Zang B., Litz R.J., Sitoci K.H., Aschenbrenner U., Gottschlich B., Daubner D., Schackert G., Sobottka S.B. Early hemorrhagic progression of traumatic brain contusions: frequency, correlation with coagulation disorders, and patient outcome: a prospective study. J. Neurotrauma. 2014; 31 (17): 1521-1527. DOI: 10.1089/neu.2013.3241. PMID: 24738836Oertel M., Kelly D.F., McArthur D., Boscardin W.J., Glenn T.C., Lee J.H., Gravori T., Obukhov D., McBride D.Q., Martin N.A. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J. Neurosurg. 2002; 96 (1): 109-116. DOI: 10.3171/jns.2002.96.1.0109. PMID: 11794591Oertel M., Kelly D.F., McArthur D., Boscardin W.J., Glenn T.C., Lee J.H., Gravori T., Obukhov D., McBride D.Q., Martin N.A. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J. Neurosurg. 2002; 96 (1): 109-116. DOI: 10.3171/jns.2002.96.1.0109. PMID: 11794591Allard C.B., Scarpelini S., Rhind S.G., Baker A.J., Shek P.N., Tien H., Fernando M., Tremblay L., Morrison L.J., Pinto R., Rizoli S.B. Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage. J. Trauma. 2009; 67 (5): 959-967. DOI: 10.1097/TA.0b013e3181ad5d37. PMID: 19901655Allard C.B., Scarpelini S., Rhind S.G., Baker A.J., Shek P.N., Tien H., Fernando M., Tremblay L., Morrison L.J., Pinto R., Rizoli S.B. Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage. J. Trauma. 2009; 67 (5): 959-967. DOI: 10.1097/TA.0b013e3181ad5d37. PMID: 19901655Потапов А.А., Лихтерман Л.Б., Кравчук А.Д., Охлопков В.А., Александрова Е.В., Филатова М.М., Маряхин А.Д., Латышев Я.А. Легкая черепно-мозговая травма. Клинические рекомендации. М.; 2016: 23.Potapov A.A., Likhterman L.B., Kravchuk A.D., Okhlopkov V.A., Aleksandrova E.V., Filatova M.M., Maryakhin A.D., Latyshev Ya.A. Light craniocerebral injury. Clinical recommendations. Moscow; 2016: 23.Kaufman H.H., Hui K.S., Mattson J.C., Borit A., Childs T.L., Hoots W.K., Bernstein D.P., Makela M.E., Wagner K.A., Kahan B.D. Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury. Neurosurgery. 1984; 15 (1): 34-42. DOI: 10.1097/00006123-198407000-00007. PMID: 6472592Kaufman H.H., Hui K.S., Mattson J.C., Borit A., Childs T.L., Hoots W.K., Bernstein D.P., Makela M.E., Wagner K.A., Kahan B.D. Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury. Neurosurgery. 1984; 15 (1): 34-42. DOI: 10.1097/00006123-198407000-00007. PMID: 6472592Stein S.C., Graham D.I., Chen X.H., Smith D.H. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery. 2004; 54 (3): 687-691. DOI: 10.1227/01.NEU.0000108641.98845.88. PMID: 15028145Stein S.C., Graham D.I., Chen X.H., Smith D.H. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery. 2004; 54 (3): 687-691. DOI: 10.1227/01.NEU.0000108641.98845.88. PMID: 15028145Schwarzmaier S.M., Kim S.W., Trabold R., Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J. Neurotrauma. 2010; 27 (1): 121-130. DOI: 10.1089/neu.2009.1114. PMID: 19803784Schwarzmaier S.M., Kim S.W., Trabold R., Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J. Neurotrauma. 2010; 27 (1): 121-130. DOI: 10.1089/neu.2009.1114. PMID: 19803784Brohi K., Cohen M.J., Davenport R.A. Acute coagulopathy of trauma: mechanism, identification and effect. Curr. Opin. Crit. Care. 2007; 13 (6): 680685 DOI: 10.1097/MCC.0b013e3282f1e78f. PMID: 17975390Brohi K., Cohen M.J., Davenport R.A. Acute coagulopathy of trauma: mechanism, identification and effect. Curr. Opin. Crit. Care. 2007; 13 (6): 680685 DOI: 10.1097/MCC.0b013e3282f1e78f. PMID: 17975390Cohen M.J., Brohi K., Ganter M.T., Manley G.T., Mackersie R.C., Pittet J.F. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J. Trauma. 2007; 63 (6): 1254-1261. DOI: 10.1097/TA.0b013e318156ee4c. PMID: 18212647Cohen M.J., Brohi K., Ganter M.T., Manley G.T., Mackersie R.C., Pittet J.F. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J. Trauma. 2007; 63 (6): 1254-1261. DOI: 10.1097/TA.0b013e318156ee4c. PMID: 18212647van der Sande J.J., Emeis J.J., Lindeman J. Intravascular coagulation: a common phenomenon in minor experimental head injury. J. Neurosurg. 1981; 54 (1): 21-25. DOI: 10.3171/jns.1981.54.1.0021. PMID: 7463116van der Sande J.J., Emeis J.J., Lindeman J. Intravascular coagulation: a common phenomenon in minor experimental head injury. J. Neurosurg. 1981; 54 (1): 21-25. DOI: 10.3171/jns.1981.54.1.0021. PMID: 7463116Cortez S.C., McIntosh T.K., Noble L.J. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res. 1989; 482 (2): 271-282. DOI: 10.1016/0006-8993(89)91190-6. PMID: 2706487Cortez S.C., McIntosh T.K., Noble L.J. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res. 1989; 482 (2): 271-282. DOI: 10.1016/0006-8993(89)91190-6. PMID: 2706487Dietrich W.D., Alonso O., Halley M. Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J. Neurotrauma. 1994; 11 (3): 289-301. DOI: 10.1089/neu.1994.11.289. PMID: 7996583Dietrich W.D., Alonso O., Halley M. Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J. Neurotrauma. 1994; 11 (3): 289-301. DOI: 10.1089/neu.1994.11.289. PMID: 7996583Dietrich W.D., Alonso O., Busto R., Prado R., Dewanjee S., Dewanjee M.K., Ginsberg M.D. Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats. J. Cereb. Blood Flow Metab. 1996; 16 (3): 481489 DOI: 10.1097/00004647-199605000-00015. PMID: 8621753Dietrich W.D., Alonso O., Busto R., Prado R., Dewanjee S., Dewanjee M.K., Ginsberg M.D. Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats. J. Cereb. Blood Flow Metab. 1996; 16 (3): 481489 DOI: 10.1097/00004647-199605000-00015. PMID: 8621753Maeda T., Katayama Y., Kawamata T., Aoyama N., Mori T. Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. Acta Neurochir. Suppl. 1997; 70: 102-105. DOI: 10.1007/978-3-7091-6837-0_32. PMID: 9416292Maeda T., Katayama Y., Kawamata T., Aoyama N., Mori T. Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. Acta Neurochir. Suppl. 1997; 70: 102-105. DOI: 10.1007/978-3-7091-6837-0_32. PMID: 9416292Scherer R.U., Spangenberg P. Procoagulant activity in patients with isolated severe head trauma. Crit. Care Med. 1998; 26 (1): 149-156. DOI: 10.1097/00003246-199801000-00031. PMID: 9428558Scherer R.U., Spangenberg P. Procoagulant activity in patients with isolated severe head trauma. Crit. Care Med. 1998; 26 (1): 149-156. DOI: 10.1097/00003246-199801000-00031. PMID: 9428558Hulka F., Mullins R.J., Frank E.H. Blunt brain injury activates the coagulation process. Arch. Surg. 1996; 131 (9): 923-927. DOI: 10.1001/archsurg.1996.01430210021004. PMID: 8790176Hulka F., Mullins R.J., Frank E.H. Blunt brain injury activates the coagulation process. Arch. Surg. 1996; 131 (9): 923-927. DOI: 10.1001/archsurg.1996.01430210021004. PMID: 8790176Stein S.C., Smith D.H. Coagulopathy in traumatic brain injury. Neurocrit. Care. 2004; 1 (4): 479-488. DOI: 10.1385/NCC:1:4:479. PMID: 16174954Stein S.C., Smith D.H. Coagulopathy in traumatic brain injury. Neurocrit. Care. 2004; 1 (4): 479-488. DOI: 10.1385/NCC:1:4:479. PMID: 16174954Pathak A., Dutta S., Marwaha N., Singh D., Varma N., Mathuriya S.N. Change in tissue thromboplastin content of brain following trauma. Neurol. India. 2005; 53 (2): 178-182. DOI: 10.4103/0028-3886.16404. PMID: 16010055Pathak A., Dutta S., Marwaha N., Singh D., Varma N., Mathuriya S.N. Change in tissue thromboplastin content of brain following trauma. Neurol. India. 2005; 53 (2): 178-182. DOI: 10.4103/0028-3886.16404. PMID: 16010055Halpern C.H., Reilly P.M., Turtz A.R., Stein S.C. Traumatic coagulopathy: the effect of brain injury. J. Neurotrauma. 2008; 25 (8): 997-1001. DOI: 10.1089/neu.2008.0548. PMID: 18687038Halpern C.H., Reilly P.M., Turtz A.R., Stein S.C. Traumatic coagulopathy: the effect of brain injury. J. Neurotrauma. 2008; 25 (8): 997-1001. DOI: 10.1089/neu.2008.0548. PMID: 18687038Nemerson Y., Giesen P.L. Some thoughts about localization and expression of tissue factor. Blood Coagul. Fibrinolysis. 1998; 9 (Suppl 1): S45S47. PMID: 9819028Nemerson Y., Giesen P.L. Some thoughts about localization and expression of tissue factor. Blood Coagul. Fibrinolysis. 1998; 9 (Suppl 1): S45S47. PMID: 9819028Carrick M.M., Tyroch A.H., Youens C.A., Handley T. Subsequent development of trombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J. Trauma. 2005; 58 (4): 725-729. DOI: 10.1097/01.TA.0000159249.68363.78. PMID: 15824648Carrick M.M., Tyroch A.H., Youens C.A., Handley T. Subsequent development of trombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J. Trauma. 2005; 58 (4): 725-729. DOI: 10.1097/01.TA.0000159249.68363.78. PMID: 15824648Nekludov M., Bellander B.M., Blombäck M., Wallen H.N. Platelet dysfunction in patients with severe traumatic brain injury. J. Neurotrauma. 2007; 24 (11): 1699-1706. DOI: 10.1089/neu.2007.0322. PMID: 18001200Nekludov M., Bellander B.M., Blombäck M., Wallen H.N. Platelet dysfunction in patients with severe traumatic brain injury. J. Neurotrauma. 2007; 24 (11): 1699-1706. DOI: 10.1089/neu.2007.0322. PMID: 18001200Schnüriger B., Inaba K., Abdelsayed G.A., Lustenberger T., Eberle B.M., Barmparas G., Talving P., Demetriades D. The impact of platelets on the progression of traumatic intracranial hemorrhage. J. Trauma. 2010; 68 (4): 881-885. DOI: 10.1097/TA.0b013e3181d3cc58. PMID: 20386283Schnüriger B., Inaba K., Abdelsayed G.A., Lustenberger T., Eberle B.M., Barmparas G., Talving P., Demetriades D. The impact of platelets on the progression of traumatic intracranial hemorrhage. J. Trauma. 2010; 68 (4): 881-885. DOI: 10.1097/TA.0b013e3181d3cc58. PMID: 20386283Laroche M., Kutcher M.E., Huang M.C., Cohen M.J., Manley G.T. Coagulopathy after traumatic brain injury. Neurosurgery. 2012; 70 (6): 13341345. DOI: 10.1227/NEU.0b013e31824d179b. PMID: 22307074Laroche M., Kutcher M.E., Huang M.C., Cohen M.J., Manley G.T. Coagulopathy after traumatic brain injury. Neurosurgery. 2012; 70 (6): 13341345. DOI: 10.1227/NEU.0b013e31824d179b. PMID: 22307074Maegele M. Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options. Transfusion. 2013; 53 (Suppl 1): 28S-37S. DOI: 10.1111/trf.12033. PMID: 23301970Maegele M. Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options. Transfusion. 2013; 53 (Suppl 1): 28S-37S. DOI: 10.1111/trf.12033. PMID: 23301970Баранич А.И., Савин И.А., Табасаранский Т.Ф., Полупан А.А., Сычев А.А., Пилипенко Ю.В., Курдюмова Н.В., Микеладзе К.Г., Элиава Ш.Ш. Нарушения системы гемостаза у пациентов с аневризматическим субарахноидальным кровоизлиянием. Вопросы нейрохирургии им. Н.Н.Бурденко. 2018; 82 (4): 109-116. PMID: 30137045Baranich A.I., Savin I.A., Tabasaranskiy T.F., Polupan A.A., Sychev A.A., Kurdyumova N.V., Pilipenko Y.V., Mikeladze K.G., Eliava S.S. Disturbances of the hemostatic system in patients with aneurysmal subarachnoid hemorrhage. Voprosy Neirokhirurgii Imeni N.N.Burdenko. 2018; 82 (4): 109-116. PMID: 30137045. [In Russ.]Harhangi B.S., Kompanje E.J., Leebeek F.W., Maas A.I. Coagulation disorders after traumatic brain injury. Acta Neurochir. (Wien). 2008; 150 (2): 165-175. DOI: 10.1007/s00701-007-1475-8. PMID: 18166989Harhangi B.S., Kompanje E.J., Leebeek F.W., Maas A.I. Coagulation disorders after traumatic brain injury. Acta Neurochir. (Wien). 2008; 150 (2): 165-175. DOI: 10.1007/s00701-007-1475-8. PMID: 18166989Keimowitz R.M., Annis B.L. Disseminated intravascular coagulation associated with massive brain injury. J. Neurosurg. 1973; 39 (2): 178-180. DOI: 10.3171/jns.1973.39.2.0178. PMID: 4719695Keimowitz R.M., Annis B.L. Disseminated intravascular coagulation associated with massive brain injury. J. Neurosurg. 1973; 39 (2): 178-180. DOI: 10.3171/jns.1973.39.2.0178. PMID: 4719695Goodnight S.H., Kenoyer G., Rapaport S.I., Patch M.J., Lee J.A., Kurze T. Defibrination after bain-tissue destruction: a serious complication of head injury. N. Engl. J. Med. 1974; 290 (19): 1043-1047. DOI: 10.1056/NEJM197405092901903. PMID: 4821906Goodnight S.H., Kenoyer G., Rapaport S.I., Patch M.J., Lee J.A., Kurze T. Defibrination after bain-tissue destruction: a serious complication of head injury. N. Engl. J. Med. 1974; 290 (19): 1043-1047. DOI: 10.1056/NEJM197405092901903. PMID: 4821906Mackman N. Tissue-specific hemostasis: role of tissue factor. J. Thromb. Haemost. 2008; 6 (2): 303-305. DOI: 10.1111/j.1538-7836.2007.02873.x. PMID: 18088348Mackman N. Tissue-specific hemostasis: role of tissue factor. J. Thromb. Haemost. 2008; 6 (2): 303-305. DOI: 10.1111/j.1538-7836.2007.02873.x. PMID: 18088348Gando S. Disseminated intravascular coagulation in trauma patients. Semin. Thromb. Hemost. 2001; 27 (6): 585–592. DOI: 10.1055/s-200118864. PMID: 11740682Gando S. Disseminated intravascular coagulation in trauma patients. Semin. Thromb. Hemost. 2001; 27 (6): 585–592. DOI: 10.1055/s-200118864. PMID: 11740682Reilly P., Bullock R. Head injury, pathophysiology and management. 2nd ed. Hodder Arnold; 2005: 129-130. ISBN 0340-80724-5Reilly P., Bullock R. Head injury, pathophysiology and management. 2nd ed. Hodder Arnold; 2005: 129-130. ISBN 0340-80724-5Matta B., Menon D., Turner J. Textbook of neuroanaesthesia and critical care. Chapter: Management of acute head injury. London: Greenwich Medical Media Ltd; 2000: 285-297. ISBN 1-900151-73-1Matta B., Menon D., Turner J. Textbook of neuroanaesthesia and critical care. Chapter: Management of acute head injury. London: Greenwich Medical Media Ltd; 2000: 285-297. ISBN 1-900151-73-1van der Sande J.J., Veltkamp J.J., Boekhout-Mussert R.J., Bouwhuis-Hoogerwerf M.L. Head injury and coagulation disorders. J. Neurosurg. 1978; 49 (3): 357-365. DOI: 10.3171/jns.1978.49.3.0357. PMID: 681997van der Sande J.J., Veltkamp J.J., Boekhout-Mussert R.J., Bouwhuis-Hoogerwerf M.L. Head injury and coagulation disorders. J. Neurosurg. 1978; 49 (3): 357-365. DOI: 10.3171/jns.1978.49.3.0357. PMID: 681997Olson J.D., Kaufman H.H., Moake J., O’Gorman T.W., Hoots K., Wagner K., Brown C.K., Gildenberg P.L. The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery. 1989; 24 (6): 825-832. DOI: 10.1097/00006123-198906000-00007. PMID: 2747858Olson J.D., Kaufman H.H., Moake J., O’Gorman T.W., Hoots K., Wagner K., Brown C.K., Gildenberg P.L. The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery. 1989; 24 (6): 825-832. DOI: 10.1097/00006123-198906000-00007. PMID: 2747858Takahashi H., Urano T., Takada Y., Nagai N., Takada A. Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate. J. Neurosurg. 1997; 86 (5): 768-772. DOI: 10.3171/jns.1997.86.5.0768. PMID: 9126890Takahashi H., Urano T., Takada Y., Nagai N., Takada A. Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate. J. Neurosurg. 1997; 86 (5): 768-772. DOI: 10.3171/jns.1997.86.5.0768. PMID: 9126890Morel N., Morel O., Petit L., Hugel B., Cochard J.F., Freyssinet J.M., Sztark F., Dabadie P. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J. Trauma. 2008; 64 (3): 698-704. DOI: 10.1097/TA.0b013e31816493ad. PMID: 18332810Morel N., Morel O., Petit L., Hugel B., Cochard J.F., Freyssinet J.M., Sztark F., Dabadie P. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J. Trauma. 2008; 64 (3): 698-704. DOI: 10.1097/TA.0b013e31816493ad. PMID: 18332810Morel N., Morel O., Delabranche X., Jesel L., Sztark F., Dabadie P., Freyssinet J.M., Toti F. Microparticles during sepsis and trauma. A link between inflammation and thrombotic processes. Ann. Fr. Anesth. Reanim. 2006; 25 (9): 955-966. DOI: 10.1016/j.annfar.2006.04.013. PMID: 16926090Morel N., Morel O., Delabranche X., Jesel L., Sztark F., Dabadie P., Freyssinet J.M., Toti F. Microparticles during sepsis and trauma. A link between inflammation and thrombotic processes. Ann. Fr. Anesth. Reanim. 2006; 25 (9): 955-966. DOI: 10.1016/j.annfar.2006.04.013. PMID: 16926090Reininger A.J., Heijnen H.F., Schumann H., Specht H.M., Schramm W., Ruggeri Z.M. Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood. 2006; 107 (9): 3537-3545. DOI: 10.1182/blood-2005-02-0618. PMID: 16449527Reininger A.J., Heijnen H.F., Schumann H., Specht H.M., Schramm W., Ruggeri Z.M. Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood. 2006; 107 (9): 3537-3545. DOI: 10.1182/blood-2005-02-0618. PMID: 16449527Mooberry M.J., Key N.S. Microparticle analysis in disorders of hemostatsis and thrombosis. Cytometry A. 2016; 89 (2): 111–122. DOI: 10.1002/cyto.a.22647. PMID: 25704723Mooberry M.J., Key N.S. Microparticle analysis in disorders of hemostatsis and thrombosis. Cytometry A. 2016; 89 (2): 111–122. DOI: 10.1002/cyto.a.22647. PMID: 25704723Burnier L., Fontana P., Kwak B.R., Angelillo-Scherrer A. Cell-derived microparticles in haemostasis and vascular medicine. Thromb. Haemost. 2009; 101 (3): 439-451. DOI: 10.1160/TH08-08-0521. PMID: 19277403Burnier L., Fontana P., Kwak B.R., Angelillo-Scherrer A. Cell-derived microparticles in haemostasis and vascular medicine. Thromb. Haemost. 2009; 101 (3): 439-451. DOI: 10.1160/TH08-08-0521. PMID: 19277403Nekludov M., Mobarrez F., Gryth D., Bellander B.M., Wallen H. Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury. J. Neurotrauma. 2014; 31 (23): 1927-1933. DOI: 10.1089/neu.2013.3168. PMID: 24956150Nekludov M., Mobarrez F., Gryth D., Bellander B.M., Wallen H. Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury. J. Neurotrauma. 2014; 31 (23): 1927-1933. DOI: 10.1089/neu.2013.3168. PMID: 24956150Vikerfors A., Mobarrez F., Bremme K., Holmström M., Ågren A., Eelde A., Bruzelius M., Antovic A., Wallén H., Svenungsson E. Studies of microparticles in patients with the antiphospholipid syndrome (APS). Lupus. 2012; 21 (7): 802-805. DOI: 10.1177/0961203312437809. PMID: 22635239Vikerfors A., Mobarrez F., Bremme K., Holmström M., Ågren A., Eelde A., Bruzelius M., Antovic A., Wallén H., Svenungsson E. Studies of microparticles in patients with the antiphospholipid syndrome (APS). Lupus. 2012; 21 (7): 802-805. DOI: 10.1177/0961203312437809. PMID: 22635239Lustenberger T., Talving P., Kobayashi L., Inaba K., Lam L., Plurad D., Demetriades D. Time course of coagulopathy in isolated severe traumatic brain injury. Injury. 2010; 41 (9): 924-928. DOI: 10.1016/j.injury.2010.04.019. PMID: 20471013Lustenberger T., Talving P., Kobayashi L., Inaba K., Lam L., Plurad D., Demetriades D. Time course of coagulopathy in isolated severe traumatic brain injury. Injury. 2010; 41 (9): 924-928. DOI: 10.1016/j.injury.2010.04.019. PMID: 20471013Cortiana M., Zagara G., Fava S., Seveso M. Coagulation abnormalities in patients with head injury. J. Neurosurg. Sci. 1986; 30 (3): 133-138. PMID: 3783267Cortiana M., Zagara G., Fava S., Seveso M. Coagulation abnormalities in patients with head injury. J. Neurosurg. Sci. 1986; 30 (3): 133-138. PMID: 3783267Kutcher M.E., Redick B.J., McCreery R.C., Crane I.M., Greenberg M.D., Cachola L.M., Nelson M.F., Cohen M.J. Characterization of platelet dysfunction after trauma. J. Trauma Acute Care Surg. 2012; 73 (1): 13-19. DOI: 10.1097/TA.0b013e318256deab. PMID: 22743367Kutcher M.E., Redick B.J., McCreery R.C., Crane I.M., Greenberg M.D., Cachola L.M., Nelson M.F., Cohen M.J. Characterization of platelet dysfunction after trauma. J. Trauma Acute Care Surg. 2012; 73 (1): 13-19. DOI: 10.1097/TA.0b013e318256deab. PMID: 22743367Vecht C.J., Minderhoud J.M., Sibinga C.T. Platelet aggregability in relation to impaired consciousness after head injury. J. Clin. Pathol. 1975; 28 (10): 814-820. DOI: 10.1136/jcp.28.10.814. PMID: 1214015Vecht C.J., Minderhoud J.M., Sibinga C.T. Platelet aggregability in relation to impaired consciousness after head injury. J. Clin. Pathol. 1975; 28 (10): 814-820. DOI: 10.1136/jcp.28.10.814. PMID: 1214015Saillant N.N., Sims C.A. Platelet dysfunction in injured patients. Mol. Cell Ther. 2014; 2: 37. DOI: 10.1186/s40591-014-0037-8. PMID: 26056601Saillant N.N., Sims C.A. Platelet dysfunction in injured patients. Mol. Cell Ther. 2014; 2: 37. DOI: 10.1186/s40591-014-0037-8. PMID: 26056601Donahue D.L., Beck J., Fritz B., Davis P., Sandoval-Cooper M.J., Thomas S.G., Yount R.A., Walsh M., Ploplis V.A., Castellino F.J. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J. Neurotrauma. 2014; 31 (4): 404-410. DOI: 10.1089/neu.2013.3089. PMID: 24040968Donahue D.L., Beck J., Fritz B., Davis P., Sandoval-Cooper M.J., Thomas S.G., Yount R.A., Walsh M., Ploplis V.A., Castellino F.J. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J. Neurotrauma. 2014; 31 (4): 404-410. DOI: 10.1089/neu.2013.3089. PMID: 24040968Lapetina E.G., Cuatrecasas P. Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets. Proc. Natl. Acad. Sci. USA. 1979; 76 (1): 121-125. DOI: 10.1073/pnas.76.1.121. PMID: 218191Lapetina E.G., Cuatrecasas P. Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets. Proc. Natl. Acad. Sci. USA. 1979; 76 (1): 121-125. DOI: 10.1073/pnas.76.1.121. PMID: 218191Wohlauer M.V., Moore E.E., Thomas S., Sauaia A., Evans E., Harr J., Silliman C.C., Ploplis V., Castellino F.J., Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J. Am. Coll. Surg. 2012; 214 (5): 739–746. DOI: 10.1016/j.jamcollsurg.2012.01.050. PMID: 22520693Wohlauer M.V., Moore E.E., Thomas S., Sauaia A., Evans E., Harr J., Silliman C.C., Ploplis V., Castellino F.J., Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J. Am. Coll. Surg. 2012; 214 (5): 739–746. DOI: 10.1016/j.jamcollsurg.2012.01.050. PMID: 22520693Castellino F.J., Chapman M.P., Donahue D.L., Thomas S., Moore E.E., Wohlauer M.V., Fritz B., Yount R., Ploplis V., Davis P., Evans E., Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J. Trauma Acute Care Surg. 2014; 76 (5): 1169–1176. DOI: 10.1097/TA.0000000000000216. PMID: 24747445Castellino F.J., Chapman M.P., Donahue D.L., Thomas S., Moore E.E., Wohlauer M.V., Fritz B., Yount R., Ploplis V., Davis P., Evans E., Walsh M. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J. Trauma Acute Care Surg. 2014; 76 (5): 1169–1176. DOI: 10.1097/TA.0000000000000216. PMID: 24747445Davis P.K., Musunuru H., Walsh M., Cassady R., Yount R., Losiniecki A., Moore E.E., Wohlauer M.V., Howard J., Ploplis V.A., Castellino F.J., Thomas S.G. Platelet dysfunction is an early marker for traumatic brain injuryinduced coagulopathy. Neurocrit. Care. 2012; 18 (2): 201–208. DOI: 10.1007/s12028-012-9745-6. PMID: 22847397Davis P.K., Musunuru H., Walsh M., Cassady R., Yount R., Losiniecki A., Moore E.E., Wohlauer M.V., Howard J., Ploplis V.A., Castellino F.J., Thomas S.G. Platelet dysfunction is an early marker for traumatic brain injuryinduced coagulopathy. Neurocrit. Care. 2012; 18 (2): 201–208. DOI: 10.1007/s12028-012-9745-6. PMID: 22847397Briggs A., Gates J.D., Kaufman R.M., Calahan C., Gormley W.B., Havens J.M. Platelet dysfunction and platelet transfusion in traumatic brain injury. J. Surg. Res. 2015; 193 (2): 802–806. DOI: 10.1016/j.jss.2014.08.016. PMID: 25218281Briggs A., Gates J.D., Kaufman R.M., Calahan C., Gormley W.B., Havens J.M. Platelet dysfunction and platelet transfusion in traumatic brain injury. J. Surg. Res. 2015; 193 (2): 802–806. DOI: 10.1016/j.jss.2014.08.016. PMID: 25218281Joseph B., Aziz H., Zangbar B., Kulvatunyou N., Pandit V., O’Keeffe T., Tang A., Wynne J., Friese R.S., Rhee P. Acquired coagulopathy of traumatic brain injury defied by routine laboratory tests: which laboratory values matter? J. Trauma Acute Care Surg. 2014; 76 (1): 121–125. DOI: 10.1097/TA.0b013e3182a9cc95. PMID: 24368366Joseph B., Aziz H., Zangbar B., Kulvatunyou N., Pandit V., O’Keeffe T., Tang A., Wynne J., Friese R.S., Rhee P. Acquired coagulopathy of traumatic brain injury defied by routine laboratory tests: which laboratory values matter? J. Trauma Acute Care Surg. 2014; 76 (1): 121–125. DOI: 10.1097/TA.0b013e3182a9cc95. PMID: 24368366Massaro A.M., Doerfler S., Nawalinski K., Michel B., Driscoll N., Ju C., Patel H., Quattrone F., Frangos S., Maloney-Wilensky E., Sean Grady M., Stein S.C., Kasner S.E., Kumar M.A. Thromboelastography defies late hypercoagulopathy after TBI: a pilot study. Neurocrit. Care. 2015; 22 (1): 45–51. DOI: 10.1007/s12028-014-0051-3. PMID: 25127903Massaro A.M., Doerfler S., Nawalinski K., Michel B., Driscoll N., Ju C., Patel H., Quattrone F., Frangos S., Maloney-Wilensky E., Sean Grady M., Stein S.C., Kasner S.E., Kumar M.A. Thromboelastography defies late hypercoagulopathy after TBI: a pilot study. Neurocrit. Care. 2015; 22 (1): 45–51. DOI: 10.1007/s12028-014-0051-3. PMID: 25127903Corps K.N., Roth T.L., McGavern D.B. Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 2015; 72 (3): 355-362. DOI: 10.1001/jamaneurol.2014.3558. PMID: 25599342Corps K.N., Roth T.L., McGavern D.B. Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 2015; 72 (3): 355-362. DOI: 10.1001/jamaneurol.2014.3558. PMID: 25599342Ramlackhansingh A.F., Brooks D.J., Greenwood R.J., Bose S.K., Turkheimer F.E., Kinnunen K.M., Gentleman S., Heckemann R.A., Gunanayagam K., Gelosa G., Sharp D.J. Inflammation after trauma: microglial activation and traumatic brain injury. Ann. Neurol. 2011; 70 (3): 374-383. DOI: 10.1002/ana.22455. PMID: 21710619Ramlackhansingh A.F., Brooks D.J., Greenwood R.J., Bose S.K., Turkheimer F.E., Kinnunen K.M., Gentleman S., Heckemann R.A., Gunanayagam K., Gelosa G., Sharp D.J. Inflammation after trauma: microglial activation and traumatic brain injury. Ann. Neurol. 2011; 70 (3): 374-383. DOI: 10.1002/ana.22455. PMID: 21710619Ярилин А.А. Иммунология. М.: ГЭОТАР-Медиа; 2010: 93-96. ISBN 978-5-9704-1319-7Yarilin A.A. Immunology. Moscow: GEOTAR-Media; 2010: 93-96. ISBN 978-5-9704-1319-7. [In Russ.]Russo M.V., McGavern D.B. Immune surveillance of the CNS following infection and injury. Trends Immunol. 2015; 36 (10): 637-650. DOI: 10.1016/j.it.2015.08.002. PMID: 26431941Russo M.V., McGavern D.B. Immune surveillance of the CNS following infection and injury. Trends Immunol. 2015; 36 (10): 637-650. DOI: 10.1016/j.it.2015.08.002. PMID: 26431941Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 2007; 81 (1): 1-5. DOI: 10.1189/jlb.0306164. PMID: 17032697Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 2007; 81 (1): 1-5. DOI: 10.1189/jlb.0306164. PMID: 17032697Morgan B.P. Mechanisms of tissue damage by the membrane attack complex of complement. Complement Inflamm. 1989; 6 (2): 104-111. DOI: 10.1159/000463082. PMID: 2656078Morgan B.P. Mechanisms of tissue damage by the membrane attack complex of complement. Complement Inflamm. 1989; 6 (2): 104-111. DOI: 10.1159/000463082. PMID: 2656078Martel C., Cointe S., Maurice P., Matar S., Ghitescu M., Théroux P., Bonnefoy A. Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. PLoS One. 2011; 6 (4): e18812. DOI: 10.1371/journal.pone.0018812. PMID: 21526204Martel C., Cointe S., Maurice P., Matar S., Ghitescu M., Théroux P., Bonnefoy A. Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. PLoS One. 2011; 6 (4): e18812. DOI: 10.1371/journal.pone.0018812. PMID: 21526204Morgan B.P. The membrane attack complex as an inflammatory trigger. Immunobiology. 2016; 221 (6): 747-751. DOI: 10.1016/j.imbio.2015.04.006. PMID: 25956457Morgan B.P. The membrane attack complex as an inflammatory trigger. Immunobiology. 2016; 221 (6): 747-751. DOI: 10.1016/j.imbio.2015.04.006. PMID: 25956457Bellander B.M., von Holst H., Fredman P., Svensson M. Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat. J. Neurosurg. 1996; 85 (3): 468-475. DOI: 10.3171/jns.1996.85.3.0468. PMID: 8751634Bellander B.M., von Holst H., Fredman P., Svensson M. Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat. J. Neurosurg. 1996; 85 (3): 468-475. DOI: 10.3171/jns.1996.85.3.0468. PMID: 8751634Bellander B.M., Singhrao S.K., Ohlsson M., Mattsson P., Svensson M. Complement activation in the human brain after traumatic head injury. J. Neurotrauma. 2001; 18 (12): 1295-1311. DOI: 10.1089/08977150152725605. PMID: 11780861Bellander B.M., Singhrao S.K., Ohlsson M., Mattsson P., Svensson M. Complement activation in the human brain after traumatic head injury. J. Neurotrauma. 2001; 18 (12): 1295-1311. DOI: 10.1089/08977150152725605. PMID: 11780861Stahel P.F., Morganti-Kossmann M.C., Kossmann T. The role of the complement system in traumatic brain injury. Brain Res. Brain Res. Rev. 1998; 27 (3): 243-256. DOI: 10.1016/S0165-0173(98)00015-0. PMID: 9729408Stahel P.F., Morganti-Kossmann M.C., Kossmann T. The role of the complement system in traumatic brain injury. Brain Res. Brain Res. Rev. 1998; 27 (3): 243-256. DOI: 10.1016/S0165-0173(98)00015-0. PMID: 9729408Rostami E., Davidsson J., Gyorgy A., Agoston D.V., Risling M., Bellander B.M. The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. J. Neurotrauma. 2013; 30 (23): 1954-1965. DOI: 10.1089/neu.2012.2583. PMID: 23808389Rostami E., Davidsson J., Gyorgy A., Agoston D.V., Risling M., Bellander B.M. The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. J. Neurotrauma. 2013; 30 (23): 1954-1965. DOI: 10.1089/neu.2012.2583. PMID: 23808389Bellander B.M., Olafsson I.H., Ghatan P.H., Bro Skejo H.P., Hansson L.O., Wanecek M., Svensson M.A. Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B. Acta Neurochir. (Wien). 2011; 153 (1): 90-100. DOI: 10.1007/s00701-010-0737-z. PMID: 20686797Bellander B.M., Olafsson I.H., Ghatan P.H., Bro Skejo H.P., Hansson L.O., Wanecek M., Svensson M.A. Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B. Acta Neurochir. (Wien). 2011; 153 (1): 90-100. DOI: 10.1007/s00701-010-0737-z. PMID: 20686797Christiaans S.C., Wagener B.M., Esmon C.T., Pittet J.F. Protein C and acute inflammation: a clinical and biological perspective. Am. J. Physiol. Lung Cell Mol. Physiol. 2013; 305 (7): L455-L466. DOI: 10.1152/ajplung.00093.2013. PMID: 23911436Christiaans S.C., Wagener B.M., Esmon C.T., Pittet J.F. Protein C and acute inflammation: a clinical and biological perspective. Am. J. Physiol. Lung Cell Mol. Physiol. 2013; 305 (7): L455-L466. DOI: 10.1152/ajplung.00093.2013. PMID: 23911436Kushimoto S., Shibata Y., Yamamoto Y. Implications of fibrinogenolysis in patients with closed head injury. J. Neurotrauma. 2003; 20 (4): 357363. DOI: 10.1089/089771503765172318. PMID: 12866815Kushimoto S., Shibata Y., Yamamoto Y. Implications of fibrinogenolysis in patients with closed head injury. J. Neurotrauma. 2003; 20 (4): 357363. DOI: 10.1089/089771503765172318. PMID: 12866815Tian H.L., Chen H., Wu B.S., Cao H.L., Xu T., Hu J., Wang G., Gao W.W., Lin Z.K., Chen S.W. D-Dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases. Neurosurg. Rev. 2010; 33 (3): 359-365. DOI: 10.1007/s10143-010-0251-z. PMID: 20349100Tian H.L., Chen H., Wu B.S., Cao H.L., Xu T., Hu J., Wang G., Gao W.W., Lin Z.K., Chen S.W. D-Dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases. Neurosurg. Rev. 2010; 33 (3): 359-365. DOI: 10.1007/s10143-010-0251-z. PMID: 20349100Kushimoto S., Yamamoto Y., Shibata Y., Sato H., Koido Y. Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery. 2001; 49 (5): 1084-1089. DOI: 10.1097/00006123-200111000-00011. PMID: 11846901Kushimoto S., Yamamoto Y., Shibata Y., Sato H., Koido Y. Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery. 2001; 49 (5): 1084-1089. DOI: 10.1097/00006123-200111000-00011. PMID: 11846901Auer L. Disturbances of the coagulatory system in patients with severe cerebral trauma. I. Acta Neurochir. (Wien). 1978; 43 (1-2): 51-59. DOI: 10.1007/BF01809225. PMID: 707171Auer L. Disturbances of the coagulatory system in patients with severe cerebral trauma. I. Acta Neurochir. (Wien). 1978; 43 (1-2): 51-59. DOI: 10.1007/BF01809225. PMID: 707171Auer L.M., Ott E. Disturbances of the coagulatory system in patients with severe cerebral trauma II. Platelet function. Acta Neurochir. (Wien). 1979; 49 (3-4): 219-226. DOI: 10.1007/BF01808961. PMID: 517179Auer L.M., Ott E. Disturbances of the coagulatory system in patients with severe cerebral trauma II. Platelet function. Acta Neurochir. (Wien). 1979; 49 (3-4): 219-226. DOI: 10.1007/BF01808961. PMID: 517179Touho H., Hirakawa K., Hino A., Karasawa J., Ohno Y. Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury. Neurosurgery. 1986; 19 (4): 523-531. DOI: 10.1227/00006123-198610000-00005. PMID: 3785592Touho H., Hirakawa K., Hino A., Karasawa J., Ohno Y. Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury. Neurosurgery. 1986; 19 (4): 523-531. DOI: 10.1227/00006123-198610000-00005. PMID: 3785592Crone K.R., Lee K.S., Kelly D.L.Jr. Correlation of admission fibrin degradation products with outcome and respiratory failure in patients with severe head injury. Neurosurgery. 1987; 21 (4): 532-536. DOI: 10.1227/00006123-198710000-00015. PMID: 3683787Crone K.R., Lee K.S., Kelly D.L.Jr. Correlation of admission fibrin degradation products with outcome and respiratory failure in patients with severe head injury. Neurosurgery. 1987; 21 (4): 532-536. DOI: 10.1227/00006123-198710000-00015. PMID: 3683787Selladurai B.M., Vickneswaran M., Duraisamy S., Atan M. Coagulopathy in acute head injury: a study of its role as a prognostic indicator. Br. J. Neurosurg. 1997; 11 (5): 398-404. DOI: 10.1080/02688699745880. PMID: 9474270Selladurai B.M., Vickneswaran M., Duraisamy S., Atan M. Coagulopathy in acute head injury: a study of its role as a prognostic indicator. Br. J. Neurosurg. 1997; 11 (5): 398-404. DOI: 10.1080/02688699745880. PMID: 9474270

The authors declare that there are no conflicts of interest present.