rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2019-2-99-114rmt-1746Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSФосфолипиды синаптических мембран в патогенезе энцефалопатии при геморрагическом шоке (обзор)Phospholipids of Synaptic Membranes in the Pathogenesis of Encephalopathy During Hemorrhagic Shock (Review)ЛесковаГ. Ф.LeskovaG. F.

Галина Федоровна Лескова 

125315, г. Москва, ул. Балтийская, д. 8

Galina F. Leskova 

8 Baltiyskaya Str., Moscow 125315

 

leskovagalina@rambler.ruНаучно-исследовательский институт общей патологии и патофизиологииРоссияScientific Research Institute of General Pathology and PathophysiologyRussian Federation20193004201915299114Copyright © Лескова Г.Ф., 20192019Лескова Г.Ф.Leskova G.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1746

Коррекция клеточных повреждений головного мозга, вызванных массивной кровопотерей, является одной из наиболее трудно решаемых проблем при геморрагическом шоке, что создает необходимость изучения механизмов таких повреждений с перспективой теоретического обоснования подходов к восстановлению функциональной активности нейронов. Анализ представленных в статье данных позволяет считать, что дисрегуляция метаболизма фосфолипидов лежит в основе как структурных повреждений синаптических мембран, так и их функций, включая рецепторную сигнализацию, нарушения которой при геморрагическом шоке приводят к энцефалопатии. Коррекция фосфолипидного состава синаптических мембран имеет особенную значимость для повышения эффективности лечения шокогенных нарушений функций головного мозга.

Correction of brain cell damages caused by massive blood loss is one of the urgent problems of hemorrhagic shock, which ensures the need in clarification of mechanisms of such damages with the prospect of developing strategies to restore the functional activity of neurons. Analysis of the data presented in the review suggests that the dysregulation of phospholipid metabolism underlies both structural damage of synaptic membranes and their functions, including receptor signaling, the disturbances of which lead to encephalopathy in hemorrhagic shock. Correction of synaptic membranes phospholipid composition seems to possess a potential for increasing the effectiveness of treatment of shock-induced brain function disorders.

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The authors declare that there are no conflicts of interest present.