rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2019-2-79-98rmt-1751Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSРоль апоптоза в патогенезе некоторых критических состоянийThe Role of Apoptosis in the Pathogenic Mechanism of Critical States (Review)ГлуховА. И.GlukhovA. I.

Alexander I. Glukhov 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

ГрызуноваГ. К.GryzunovaG. K.

Galina K. Gryzunova 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

УсайЛ. И.UsaiL. I.

Людмила Ивановна Усай

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Ludmila I. Usai 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

usaylee@mail.ruАлейниковаТ. Л.AleynikovaT L.

Tatiana L. Aleynikova 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

ЧерниковаН. В.ChernikovaN. V.

Natalya V. Chernikova 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

БуртА. Ю.BurtA. Yu.

Andrey Yu. Burt 

8 Trubetskaya Str., Bldg. 2, 119991 Moscow

Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Московский государственный университет им. М. В. ЛомоносоваРоссияI. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; M. V. Lomonosov Moscow State UniversityRussian FederationПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииРоссияI. M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation2019300420191527998Copyright © Глухов А.И., Грызунова Г.К., Усай Л.И., Алейникова Т.Л., Черникова Н.В., Бурт А.Ю., 20192019Глухов А.И., Грызунова Г.К., Усай Л.И., Алейникова Т.Л., Черникова Н.В., Бурт А.Ю.Glukhov A.I., Gryzunova G.K., Usai L.I., Aleynikova T.L., Chernikova N.V., Burt A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1751

Цель обзора — анализ роли апоптоза в патогенезе некоторых критических состояний и описание особенностей биохимических процессов, вовлеченных в его развитие. В статью включено 117 публикаций, в том числе 76 за последние пять лет. Анализ обсуждаемых работ показывает, что способность управлять эндогенными апоптическими процессами открывает возможности для разработки подходов функциональной терапии ряда заболеваний.

The purpose of the overview is to analyze the role of apoptosis in the pathogenesis of critical illness and discuss specific features of contributed biochemical processes. The paper reviews 117 publications, 76 of which were published during the recent five years. Published data show that the ability to control endogenic apoptotic processes offers opportunities for the development of functional therapy approaches to various diseases.

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The authors declare that there are no conflicts of interest present.