rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2019-5-74-87rmt-1819Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSЗаболевания печени и гемостаз (обзор) Часть I. Нехолестатические заболевания печени и гемостазLiver Diseases and the Hemostasis (Rewiew) Part 1. Non-Cholestatic Diseases of the Liver and HemostasisРешетнякВ. И.ReshetnyakV. I.

Россия, 127473, г. Москва, ул. Делегатская, д. 20, стр. 1

20 Delegatskaya Str., Build 1, 127473 Moscow, Russia

vasiliy.reshetnyak@yandex.ruМаевИ. В.MaevI. V.

Россия, 127473, г. Москва, ул. Делегатская, д. 20, стр. 1

20 Delegatskaya Str., Build 1, 127473 Moscow, Russia

РешетнякТ. М.ReshetnyakT. M.

Россия, 115522, г. Москва, Каширское шоссе, д. 34А

34A Kashirskoye highway, Moscow 115522, Russia

ЖуравельС. В.ZhuravelS. V.

Россия, 129090, г. Москва, Большая Сухаревская пл., д. 3

3 Bolshaya Sukharevskaya Square, Moscow 129090, Russia

ПисаревВ. М.PisarevV. M.

Россия, 107031, г. Москва, ул. Петровка, д. 25, стр. 2

25 Petrovka Str., Build. 2, 107031 Moscow, Russia

Московский государственный медико-стоматологический университет им. А. И. Евдокимова Минздрава РоссииРоссияA. I. Evdokimov Moscow State University of medicine and dentistry, Ministry of Health of RussiaRussian FederationНИИ ревматологии им. В. А. НасоновойРоссияV. A. Nasonova Research Institute of RheumatologyRussian FederationНИИ скорой помощи им. Н. В. Склифосовского ДЗМРоссияN. V. Sklifosovsky Research Institute of Emergency Care, Moscow Healthcare DepartmentRussian FederationНИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРРоссияV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyRussian Federation2019081120191557487Copyright © Решетняк В.И., Маев И.В., Решетняк Т.М., Журавель С.В., Писарев В.М., 20192019Решетняк В.И., Маев И.В., Решетняк Т.М., Журавель С.В., Писарев В.М.Reshetnyak V.I., Maev I.V., Reshetnyak T.M., Zhuravel S.V., Pisarev V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/1819

При заболеваниях печени, особенно в терминальной стадии печеночной недостаточности, развиваются разнообразные гемостатические дефекты, которые затрагивают практически все звенья свертывающей системы крови. Это приводит к тому, что пациенты с заболеваниями печени имеют узкую полосу поддержания гемостатического баланса.Тяжесть нарушений гемостаза зависит от нозологической формы и степени повреждения печени. В зависимости от дисбаланса системы гемостаза, особенностей клинико-лабораторных данных, пациентов с заболеваниями печени условно можно разделить на три группы: 1. Нехолестатические повреждения печени; 2. Холестатические повреждения печени и 3. Повреждения печени сосудистого генеза.В первой части обзора обсуждаются вопросы изменения в системе гемостаза у пациентов с нехолестатическими заболеваниями печени, которые как правило, сопровождаются гипокоагуляцией.

In liver diseases, most commonly in the terminal stage of liver failure, a variety of hemostatic defects affecting almost all parts of the blood coagulation system are developing. This leads to diminishing the capabilities of patients with liver diseases to correctly maintain the hemostatic balance.The severity of hemostatic disorders depends on the nosological form and degree of a liver damage. Depending on the imbalance of the hemostasis system and accumulated clinical/laboratory data, patients with liver diseases can be subdivided into three groups as exhibiting: 1. non-cholestatic liver damage; 2. cholestatic liver damage and 3. liver damage of vascular origin.The first part of the review discusses multiple alterations in the hemostasis system in patients with noncholestatic liver diseases, which are commonly accompanied by hypocoagulation.

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The authors declare that there are no conflicts of interest present.