rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2021-1-27-33rmt-2012Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ И ПРАКТИКАCLINICAL STUDIES AND PRACTICEПрогнозирование возможности питания в тонкую кишку у пациентов с распространенным вторичным перитонитомPredicting The Feasibility of Small Bowel Feeding in Patients With Generalized Secondary PeritonitisСивковО. Г.SivkovO. G.

Олег Геннадьевич Сивков

625000, г. Тюмень, ул. Юрия Семовских, д. 8, стр. 1,

625023, г. Тюмень, ул. Одесская, д. 54

Oleg G. Sivkov

8/1 Yuri Semovskih Str., 625000 Tyumen

54 Odesskay Str., 625023 Tyumen

sivkovog@mail.ruМедико-санитарная часть «Нефтяник»; Тюменский государственный медицинский университет Минздрава РоссииРоссияMedical and Sanitary Unit «Neftyanik»; Tyumen State Medical University, Ministry of Health of RussiaRussian Federation2021250220211712733Copyright © Сивков О.Г., 20212021Сивков О.Г.Sivkov O.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/2012Цель

Цель. Оценить в пилотном исследовании информативность теста абсорбции ацетаминофена при постпилорическом введении препарата у больных с распространенным вторичным перитонитом.

Материалы и методы

Материалы и методы. Тест абсорбции ацетаминофена выполнили пациентам с распространенным вторичным перитонитом. В назоеюнальный зонд вводили 0,5 г препарата в просвет тонкой кишки и спустя 5, 10, 15, 20, 30, 40, 50 и 90 мин определяли его концентрацию в крови. Первую группу (n=14) составили пациенты, тест которым выполнили сразу после оперативного вмешательства. Вторую группу (n=10) составили те же пациенты, тест которым выполнили в период, когда они были способны усвоить >1 л/сут. энтерального питания без признаков его непереносимости.

Результаты

Результаты. При сравнении концентрации ацетаминофена в крови после его введения в тонкую кишку пациентам с перитонитом сразу после операции и в период возможности усвоения энтерального питания обнаружили, что наиболее выраженные статистически значимые различия выявляются во временном интервале 5–20 минут (P<0,001). Этот интервал времени является оптимальным для забора крови при проведении ацетаминофенового теста.

Заключение

Заключение. Тест абсорбции ацетаминофена в тонкий кишечник у пациентов с распространенным вторичным перитонитом может быть информативен для прогноза проведения полноценного постпилорического энтерального питания.

Finding a simple reproducible routine test is relevant for the determination of post-pyloric feeding tolerance.

Aim

Aim. To evaluate in a pilot study the usefulness of acetaminophen absorption test with post-pyloric drug administration in patients with generalized secondary peritonitis.

Materials and methods

Materials and methods. Acetaminophen absorption test was performed in patients with generalized secondary peritonitis. 0.5 g of drug was administered into the lumen of the small intestine through the nasojejunal tube and after 5, 10, 15, 20, 30, 40, 50 and 90 min its blood level was determined. The first group (n=14) of variables was taken from patients whose test was performed immediately after the surgery. The second group results (n=10) were obtained from the same patients who were tested when they were able to absorb >1 l/day of enteral nutrition without signs of intolerance.

Results

Results. When comparing the concentration of acetaminophen in the blood after the drug administration into the bowel of patients with peritonitis immediately after surgery and at the time when the assimilation of bowel feeding had become possible, it was found that the most significant differences were detected within the time interval of 5–20 minutes after the drug administration (P<0.001). This time interval is optimal for harvesting blood samples during the acetaminophen test procedure.

Conclusion

Conclusion. Bowel absorption of acetaminophen may be informative for predicting the feasibility of adequate post-pyloric enteral feeding of patients with generalized secondary peritonitis.

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The authors declare that there are no conflicts of interest present.