Материал

rmt

Общая реаниматология

General Reanimatology

1813-97792411-7110

FSBI "SRIGR" RAMS

10.15360/1813-9779-2021-1-69-82

rmt-2015

Research Article

ОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯ

REVIEWS & SHORT COMMUNICATIONS

Сроки хранения фильтрованных эритроцитов и посттрансфузионные осложнения (обзор)

Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review)

Мороз

В. В.

Moroz

V. V.

107031, г. Москва, ул. Петровка, д. 25, стр. 2

Viktor V. Moroz

25 Petrovka Str., Bldg. 2, 107031 Moscow

Шерстюкова

Е. А.

Sherstyukova

E. A.

Екатерина Александровна Шерстюкова

107031, г. Москва, ул. Петровка, д. 25, стр. 2,

119991, г. Москва, ул. Большая Пироговская, д. 2, стр. 4

Ekaterina A. Sherstyukova

25 Petrovka Str., Bldg. 2, 107031 Moscow,

2-4 Bolshaya Pirogovskaya Str., 119991 Moscow

orbf@mail.ru

Козлова

Е. К.

Kozlova

E. K.

107031, г. Москва, ул. Петровка, д. 25, стр. 2,

119991, г. Москва, ул. Большая Пироговская, д. 2, стр. 4

Elena K. Kozlova

25 Petrovka Str., Bldg. 2, 107031 Moscow,

2-4 Bolshaya Pirogovskaya Str., 119991 Moscow

Сергунова

В. А.

Sergunova

V. A.

107031, г. Москва, ул. Петровка, д. 25, стр. 2

Victoria A. Sergunova

25 Petrovka Str., Bldg. 2, 107031 Moscow

НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРРоссияV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyRussian Federation

НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР; Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииРоссияV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation

2021

25022021

1716982

2021

Мороз В.В., Шерстюкова Е.А., Козлова Е.К., Сергунова В.А.

Moroz V.V., Sherstyukova E.A., Kozlova E.K., Sergunova V.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.reanimatology.com/rmt/article/view/2015

Эритроциты являются наиболее востребованным продуктом для переливания крови во всем мире. При этом вопрос безопасности и эффективности гемотрансфузии остается актуальным. Неясна причина и патогенез возникновения посттрансфузионных осложнений.

Цель обзора — обобщить данные клинических и научных исследований по эффективности гемотрансфузии эритроцитарной взвеси различных сроков хранения.

Материал

Материал. В базах данных Web of Science, Scopus и РИНЦ отобрали 76 источников, содержавших актуальные данные клинических и научных исследований по теме данного обзора, а также рекомендации по переливанию крови.

Результаты

Результаты. Рассмотрели основные этапы заготовки и условия хранения фильтрованных эритроцитов; описали биохимические и структурные изменения, которые происходят во время ее хранения; привели клинические данные, касающиеся посттрансфузионных осложнений; проанализировали клинические последствия и нарушения молекулярной структуры эритроцитов в зависимости от срока их хранения.

Заключение

Заключение. Во время длительного хранения эритроциты подвергаются значительным структурным и метаболическим изменениям. Использование в клинике относительно «старых» эритроцитов увеличивает риск возникновения посттрансфузионных осложнений. Однако остается неясно, в чем состоят патофизиологические отличия «молодых» и «старых» эритроцитов. Проведение больших клинических и научных исследований на молекулярном уровне в совокупности могут найти ответы на эти вопросы.

Red blood cells are the most required blood transfusion products worldwide. Safety and efficacy of blood transfusion are still relevant issues. Clarification of the causes and mechanisms of post-transfusion complications requires additional research.

Aim of the review is to summarize the data of clinical and research studies on transfusion of red blood cell suspension with various storage times.

Material

Material. We selected 76 sources from Web of Science, Scopus, and RSCI databases containing pertinent clinical and scientific research data, as well as blood transfusion guidelines.

Results

Results. We reviewed the main stages of preparation and storage of filtered red blood cells, described biochemical and structural alterations occurring during blood storage, summarized clinical data on post-transfusion complications, and analyzed clinical consequences and molecular structure abnormalities of red blood cells in relation to their storage time.

Conclusion

Conclusion. During long-term storage, red blood cells undergo significant structural and metabolic changes. The clinical use of relatively «old» red blood cells increases the risk of post-transfusion complications. However, the pathophysiological differences between «young» and «old» erythrocytes remain unclear. Large clinical and molecular research studies may add to our understanding of the complex issues related to blood transfusion.

хранение эритроцитарной взвесигемотрансфузияпосттрансфузионные осложнения

storage of packed red blood cellblood transfusionpost-transfusion complications

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The authors declare that there are no conflicts of interest present.