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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rmt</journal-id><journal-title-group><journal-title xml:lang="ru">Общая реаниматология</journal-title><trans-title-group xml:lang="en"><trans-title>General Reanimatology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-9779</issn><issn pub-type="epub">2411-7110</issn><publisher><publisher-name>FSBI "SRIGR" RAMS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15360/1813-9779-2023-4-2341</article-id><article-id custom-type="elpub" pub-id-type="custom">rmt-2341</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOR PRACTIONER</subject></subj-group></article-categories><title-group><article-title>Особенности респираторной поддержки у пациентов  с различным индексом массы тела во время робот-ассистированной радикальной простатэктомии</article-title><trans-title-group xml:lang="en"><trans-title>Features of Mechanical Lung Ventilation During Robot-Assisted  Radical Prostatectomy in Patients with Different Body Mass Index</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-2271-1627</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казаков</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazakov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Сергеевич Казаков</p><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2  </p><p>101234, г. Москва, ул. Вучетича, д. 21 </p></bio><bio xml:lang="en"><p>25 Petrovka Str., Bldg. 2, 107031 Moscow</p><p>21 Vuchetich Str., 101234 Moscow</p></bio><email xlink:type="simple">anesteziolog@icloud.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гребенчиков</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grebenchikov</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2  </p></bio><bio xml:lang="en"><p>25 Petrovka Str., Bldg. 2, 107031 Moscow</p></bio><email xlink:type="simple">oleg.grebenchikov@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5758-8552</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ершов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ershov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>107031, г. Москва, ул. Петровка, д. 25, стр. 2  </p><p>119992, Москва, ул. Трубецкая, д. 8, стр. 2 </p></bio><bio xml:lang="en"><p>25 Petrovka Str., Bldg. 2, 107031 Moscow</p><p>8 Trubetskaya Str., Bldg. 2, 119991 Moscow</p></bio><email xlink:type="simple">salavatprof@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральный научно-клинический центр реаниматологии и реабилитологии;  Городская клиническая больница им. С.И. Спасокукоцкого Департамента здравоохранения г. Москвы<country>Россия</country></aff><aff xml:lang="en">Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Spasokukotsky City Clinical Hospital, Moscow City Health Department<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральный научно-клинический центр реаниматологии и реабилитологии<country>Россия</country></aff><aff xml:lang="en">Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Федеральный научно-клинический центр реаниматологии и реабилитологии; Первый Московский государственный медицинский университет им. И. М. Сеченова Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology;	I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2023</year></pub-date><volume>19</volume><issue>4</issue><fpage>20</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Казаков А.С., Гребенчиков О.А., Ершов А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Казаков А.С., Гребенчиков О.А., Ершов А.В.</copyright-holder><copyright-holder xml:lang="en">Kazakov A.S., Grebenchikov O.A., Ershov A.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.reanimatology.com/rmt/article/view/2341">https://www.reanimatology.com/rmt/article/view/2341</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Оценка влияния карбоксиперитонеума и положения Тренделенбурга на биомеханику дыхания и показатели газообмена пациентов с различным индексом массы тела во время робот-ассистированной радикальной простатэктомии (РРП) и разработка алгоритма выбора оптимального режима респираторной поддержки. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включили 141 пациента с верифицированным раком предстательной железы, которым предстояло выполнение РРП. В зависимости от индекса массы тела (ИМТ) пациентов разделили на 2 группы: в группу I вошли 88 человек с ИМТ30, в группу II — 53 человека с ИМТ30. В каждой группе изучили показатели биомеханики дыхания и газообмена при ИВЛ в различных режимах (Volume Control Ventilation (VCV), Pressure Control Ventilation (PCV), Pressure Control Ventilation — Inverse Ratio Ventilation (PCV-IRV)). Данные показатели анализировали на 5 этапах операции.</p></sec><sec><title>Результаты</title><p>Результаты. Основные параметры эффективности и безопасности респираторной поддержки при РРП в группе пациентов с ИМТ30 при любом использованном режиме ИВЛ значимо не отличались. У пациентов с ожирением использование режима VCV, начиная с этапа приведения в 35° положение Тренделенбурга, привело к значимому росту величины пикового давления в дыхательных путях Ppeak, угрожая развитием бароповреждения легких, а также сопровождалось значимо меньшими значениями SpO₂, начиная с этапа наложения карбоксиперитонеума и до окончания оперативного вмешательства.</p></sec><sec><title>Заключение</title><p>Заключение. У пациентов без ожирения выбор какого-либо конкретного режима ИВЛ не имеет решающего значения в достижении безопасности и эффективности анестезиологического обеспечения РРП. Оптимальным методом ИВЛ при проведении анестезии у пациентов с РРП и ИМТ30 можно считать вентиляцию с управляемым давлением (PCV) и ее вариант с инверсией времени вдоха-выдоха (PCV-IRV), с соотношением вдох/выдох 1,5:1. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The aim of the study</title><p>The aim of the study. To evaluate effects of carboxyperitoneum and steep Trendenburg position on respiratory biomechanics and gas exchange indicators in patients with different body mass index (BMI) during robotic-assisted radical prostatectomy (RRP). To develop an algorithm for choosing the optimal mechanical lung ventilation (MLV) regimen. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 141 patients with verified prostate cancer who were candidates for RPR. Participants were divided into 2 groups based on BMI: group I included 88 patients with BMI30 kg/m2, group II — 53 patients with BMI30 kg/m2. Indicators of respiratory biomechanics and gas exchange during ventilation in various modes (Volume Controlled Ventilation (VCV), Pressure Controlled Ventilation (PCV), Pressure Controlled– Inverse Ratio Ventilation (PC-IRV) were analyzed in each group at 5 consecutive stages of the procedure.</p></sec><sec><title>Results</title><p>Results. The key parameters evidencing the effectiveness and safety of MLV during RRP procedure did not vary significantly under various ventilation regimens in the group of patients with a BMI30 kg/m2. Whilst in obese patients the use of VCV mode resulted in a significant increase of airway peak pressure (Ppeak) already at the stage of placing them into a steep Trendelenburg position (35°), thus endangering with the development of ventilator-induced lung injury. Increased Ppeak was also accompanied by the drop in oxygen saturation and significantly lower SpO₂ values, starting from the stage of applying carboxyperitoneum and until the end of surgical intervention.</p></sec><sec><title>Conclusion</title><p>Conclusion. In non-obese patients, there’s no particular ventilator regimen that is crucial for achieving the safety and effectiveness of RRP anesthesia management, all regimens can be used. In patients with BMI30 kg/m2 PCV regimen and PC-IRV with inhalation/exhalation ratio of 1.5:1  can be considered as the optimal strategy for MLV during anesthesia for RRP surgery.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>робот-ассистированная простатэктомия</kwd><kwd>положение Тренделенбурга</kwd><kwd>респираторная поддержка</kwd><kwd>ожирение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>robotic-assisted prostatectomy</kwd><kwd>Trendelenburg position</kwd><kwd>respiratory support</kwd><kwd>obesity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пушкарь Д.Ю., Колонтарев К.Б. Робот-ассистированная радикальная простатэктомия. Функциональный результат. Часть I. Хирургия. Журнал им. Н. И. Пирогова. 2019; 3: 83–86. DOI 10.17116/hirurgia201904180.</mixed-citation><mixed-citation xml:lang="en">Pushkar D.Yu., Kolontarev K.B. 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