References

rmt

Общая реаниматология

General Reanimatology

1813-97792411-7110

FSBI "SRIGR" RAMS

10.15360/1813-9779-2011-6-59

rmt-257

Research Article

ОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯ

REVIEWS & SHORT COMMUNICATIONS

Ишемическое и фармакологическое прекондиционирование

Ischemic and Pharmacological Preconditioning

Лихванцев

В. В.

Likhvantsev

V. V.

lik0704@gmail.com

Мороз

В. В

Moroz

V. V.

Гребенчиков

О. А.

Grebenchikov

O. A.

Гороховатский

Ю. И,

Gorokhovatsky

Yu. I.,

Заржецкий

Ю. В.

Zarzhetsky

Yu. V.

Тимошин

С. С.

Timoshin

S. S.

Левиков

Д. И.

Levikov

D. I.

Шайбакова

В. Л.,

Shaibakova

V. L.

2011

20122011

Том VII № 6 2011 г.

5959

2011

Лихванцев В.В., Мороз В.В., Гребенчиков О.А., Гороховатский Ю.И., Заржецкий Ю.В., Тимошин С.С., Левиков Д.И., Шайбакова В.Л.

Likhvantsev V.V., Moroz V.V., Grebenchikov O.A., Gorokhovatsky Y.I., Zarzhetsky Y.V., Timoshin S.S., Levikov D.I., Shaibakova V.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.reanimatology.com/rmt/article/view/257

Обзорная статья посвящена проблеме ишемического прекондиционирования — универсального физиологического механизма защиты клетки от гипоксии. «Прекондиционирование» — термин, используемый для описания феномена повышения толерантности клетки к воздействию повреждающего фактора в результате предварительного влияния на нее стрессорных стимулов. В статье описан феномен ишемического прекондиционирования, суммированы результаты исследования возможных механизмов реализации данного эффекта в органах и тканях. Обсуждается ключевая роль фермента гликогенсинтазы киназы 3 бета в регуляции митохондриальной поры и последней в защите клетки от гипоксии. Приведены данные экспериментальных исследований по тестированию различных препаратов в качестве фармакологических агентов инициирующих/ингибирующих прекондиционирование. Анализируются причины избирательной эффективности некоторых антигипоксантов и антиоксидантов с позиции теории ишемического преконди-ционирования. Рассматриваются традиционные анестетики и анальгетики как потенциальные индукторы или ингибиторы обсуждаемого процесса. Ключевые слова: ишемическое прекондиционирование, гипоксия, анестетики, цитопротекция.

The review article deals with the problem of ischemic preconditioning, the universal physiological mechanism of cell protection from hypoxia. Preconditioning is the term used to describe a phenomenon of the enhanced tolerance of a cell to a damaging factor due to its preliminary effects of stressful stimuli. The article describes the phenomenon of ischemic preconditioning and summarizes the results of a study of the possible mechanisms of this effect in organs and tissues. It discusses the key role of the enzyme glycogen synthase 3fl in the regulation of the mitochondrial pore and that of the latter in the protection of a cell from hypoxia. Experimental data are given on the testing of different drugs as pharmacological agents that initiate/inhibit preconditioning. Reasons for the selective efficacy of some antihypoxants and antioxidants are analyzed in the context of the ischemic preconditioning theory. Conventional anesthetics and analgesics as potential inductors or inhibitors of the process in question are discussed. Key words: ischemic preconditioning, hypoxia, anesthetics, cyto-protection.

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The authors declare that there are no conflicts of interest present.