rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2011-3-70rmt-306Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSРоль триггерного рецептора, экспрессируемого на миелоидных клетках, в активации врожденного иммунитетаRole of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate ImmunityМатвееваВ. Г.MatveyevaV. G.-ГоловкинА. С.GolovkinA. S.golovkin_a@mail.ruГригорьевЕ. В.GrigoryevE. V.-ПонасенкоА. В.PonasenkoA. V.-20112006201173Том VII № 3 2011 г.7070Copyright © Матвеева В.Г., Головкин А.С., Григорьев Е.В., Понасенко А.В., 20112011Матвеева В.Г., Головкин А.С., Григорьев Е.В., Понасенко А.В.Matveyeva V.G., Golovkin A.S., Grigoryev E.V., Ponasenko A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/306

Ключевую роль в запуске системного воспалительного ответа (СВО) играет врожденная иммунная система. Рецептор TREM-1 (триггерный рецептор, экспрессируемый на миелоидных клетках), расположенный на нейтрофилах и моноцитах, участвует в системном воспалительном ответе, регулируя эффекторные механизмы врожденного иммунитета. Патогенетическим звеном гиперергической фазы острого системного воспаления является гиперпродукция провоспалительных цитокинов. Одновременная активация Toll-like рецепторов (TLRs) и TREM-1 многократно усиливает продукцию цитокинов. Это носит компенсаторно-приспособительный характер, однако при чрезмерной выработке приводит к повреждению органов и тканей. Ключевые слова: TREM-1, TLR, цитокины, воспаление.

The innate immune system plays a key role in triggering a systemic inflammatory response (SIR). The triggering receptor expressed on myeloid cells (TREM-1), which is located on neutrophils and monocytes, is involved in SIR, by regulating the effector mechanisms of innate immunity. Hyperproduction of proinflammatory cytokines is a pathogenetic component of the hyperergic phase of acute systemic inflammation. The simultaneous activation of Toll-like receptors and TREM-1 increases the production of cytokines manifold. This is compensatory and adaptive, however, resulting in damage to organs and tissues during excessive production of cytokines. Key words: triggering receptor expressed on myeloid cells, Toll-like receptors, cytokines, inflammation.

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The authors declare that there are no conflicts of interest present.