<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rmt</journal-id><journal-title-group><journal-title xml:lang="ru">Общая реаниматология</journal-title><trans-title-group xml:lang="en"><trans-title>General Reanimatology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-9779</issn><issn pub-type="epub">2411-7110</issn><publisher><publisher-name>FSBI "SRIGR" RAMS</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15360/1813-9779-2010-5-31</article-id><article-id custom-type="elpub" pub-id-type="custom">rmt-388</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOR PRACTIONER</subject></subj-group></article-categories><title-group><article-title>Полиорганная недостаточность после кардиохирургических вмешательств</article-title><trans-title-group xml:lang="en"><trans-title>Multiple Organ Dysfunction After Cardiosurgical Interventions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>L. S.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoryev</surname><given-names>Ye. V.</given-names></name></name-alternatives><email xlink:type="simple">Grigorievev@mail.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотников</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikov</surname><given-names>G. P.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаес</surname><given-names>Б. Л.,</given-names></name><name name-style="western" xml:lang="en"><surname>Hayes</surname><given-names>B. L,</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеенков</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseyenkov</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шукевич</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shukevich</surname><given-names>D. L.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Одаренко</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Odarenko</surname><given-names>Yu. N.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2010</year></pub-date><volume>6</volume><issue>5</issue><issue-title>Том VI № 5 2010 г.</issue-title><fpage>31</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барбараш Л.С., Григорьев Е.В., Плотников Г.П., Хаес Б.Л., Моисеенков Г.В., Шукевич Д.Л., Иванов С.В., Одаренко Ю.Н., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Барбараш Л.С., Григорьев Е.В., Плотников Г.П., Хаес Б.Л., Моисеенков Г.В., Шукевич Д.Л., Иванов С.В., Одаренко Ю.Н.</copyright-holder><copyright-holder xml:lang="en">Barbarash L.S., Grigoryev Y.V., Plotnikov G.P., Hayes B.L., Moiseyenkov G.V., Shukevich D.L., Ivanov S.V., Odarenko Y.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.reanimatology.com/rmt/article/view/388">https://www.reanimatology.com/rmt/article/view/388</self-uri><abstract><p>Цель исследования — изучить клиническую эффективность внедрения алгоритма органопротективной интенсивной терапии. Материал и методы. Ретроспективный анализ 3278 историй болезни пациентов, поступавших в клинику в 2000—2009 гг. для оперативного лечения (в условиях искусственного кровообращения) ишемической болезни сердца (ИБС) и приобретенных пороков сердца (ППС). За весь анализируемый период пациентов, оперированных по поводу ИБС — 2068 (63,1%), по поводу ППС — 1210 (36,9%); частота развития полиорганной недостаточности у всех пациентов в послеоперационном периоде 11,8% (378 пациентов); летальность при ПОН 3,75% (123) от всех оперированных (включенных в исследование), или 32,5% от всех с ПОН. Заключение. Частота развития ПОН пропорциональна количеству оперативных вмешательств, зависит от особенностей вмешательства (повторный характер, исходная тяжесть больных и сопутствующая патология, мультифокальный атеросклероз). Превентивная интенсивная терапия ПОН снизила летальность и изменила синдромальную структуру в сторону преобладания гнойно-септических осложнений. Ключевые слов: кардиохирургия, искусственное кровообращение, полиорганная недостаточность.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to study the clinical efficiency of introducing an algorithm for organ-protective intensive care. Materials and methods. 3278 case histories of patients admitted to the clinic in 2000—2009 for surgical treatment (under extracorporeal circulation) for coronary heart disease (CHD) and acquired heart defects (AHD) were retrospectively analyzed. Throughout the analyzed period, the patients operated on for CHD and AHD were 2068 (63.1%) and 1210 (36.9%), respectively; the postoperative incidence of multiple organ dysfunction (MOD) among all the patients was 11.8% (378 patients); mortality in MOD was 3.75% (n=123) of the operated patients (included into the study) or 32.5% of all the patients with MOD. Conclusion. The incidence of MOD is in proportion to the number of surgical interventions and depends on their specific features (recurrence, baseline severity, comorbidity, or multifocal atherosclerosis). Preventive intensive therapy for MOD reduced mortality and altered its syndromic pattern towards a preponderance of pyoseptic complications. Key words: cardiosurgery, extracorporeal circulation, multiple organ dysfunction.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Groetzner J. P., Graeter T., Lauermann I. et al. Is gastric malperfusion and endotoxemia one motor of the systemic inflammatory response syndrome following cardiac surgery? Crit. Care 1999; 3 (Suppl A): 494—495.</mixed-citation><mixed-citation xml:lang="en">Groetzner J. P., Graeter T., Lauermann I. et al. Is gastric malperfusion and endotoxemia one motor of the systemic inflammatory response syndrome following cardiac surgery? Crit. Care 1999; 3 (Suppl A): 494—495.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rossi M., Sganga G., Mazzone M. et al. Cardiopulmonary bypass in man: role of the intestine in a selflimiting inflammatory response with demonstrable bacterial translocation. Ann. Thorac. Surg. 2004; 77 (2): 612—618.</mixed-citation><mixed-citation xml:lang="en">Rossi M., Sganga G., Mazzone M. et al. Cardiopulmonary bypass in man: role of the intestine in a selflimiting inflammatory response with demonstrable bacterial translocation. Ann. Thorac. Surg. 2004; 77 (2): 612—618.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Baue A. E., Chaudry I. H. Prevention of multiple systems failure. Surg. Clin. North Amer. 1990; 60 (5): 1167—1178.</mixed-citation><mixed-citation xml:lang="en">Baue A. E., Chaudry I. H. Prevention of multiple systems failure. Surg. Clin. North Amer. 1990; 60 (5): 1167—1178.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов И. А., Дзыбинская Е. В., Романов А. А., Баландюк А. Е. Коррекция нарушения оксигенирующей функции легких при ранней активизации кардиохирургических больных. Общая реаниматология 2009; V (2): 37—43.</mixed-citation><mixed-citation xml:lang="en">Козлов И. А., Дзыбинская Е. В., Романов А. А., Баландюк А. Е. Коррекция нарушения оксигенирующей функции легких при ранней активизации кардиохирургических больных. Общая реаниматология 2009; V (2): 37—43.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Плотников Г. П., Григорьев Е. В., Чижов А. В. и соавт. Ранняя экстракорпоральная детоксикация после кардиохирургических вмешательств. Общая реаниматология 2009; V (1): 79—82.</mixed-citation><mixed-citation xml:lang="en">Плотников Г. П., Григорьев Е. В., Чижов А. В. и соавт. Ранняя экстракорпоральная детоксикация после кардиохирургических вмешательств. Общая реаниматология 2009; V (1): 79—82.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Uchino S., Kellum J. A., Bellomo R. et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294 (7): 813—818.</mixed-citation><mixed-citation xml:lang="en">Uchino S., Kellum J. A., Bellomo R. et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294 (7): 813—818.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Oberholzer A., Oberholzer C., Moldawer L. L. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001; 16 (2): 83—96.</mixed-citation><mixed-citation xml:lang="en">Oberholzer A., Oberholzer C., Moldawer L. L. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001; 16 (2): 83—96.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Brun:Buisson C. The epidemiology of the systemic inflammatory response. Intensive Care Med. 2000; 26 (Suppl 1): S64—S74.</mixed-citation><mixed-citation xml:lang="en">Brun:Buisson C. The epidemiology of the systemic inflammatory response. Intensive Care Med. 2000; 26 (Suppl 1): S64—S74.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Белобородова Н. В., Попов Д. А., Бачинская Е. Н. Послеоперационные инфекции в кардиохирургии: современное состояние проблемы и перспективы. Грудная и сердечнососудистая хирургия 2004; 4: 25—31.</mixed-citation><mixed-citation xml:lang="en">Белобородова Н. В., Попов Д. А., Бачинская Е. Н. Послеоперационные инфекции в кардиохирургии: современное состояние проблемы и перспективы. Грудная и сердечнососудистая хирургия 2004; 4: 25—31.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
