rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2009-2-31rmt-594Research ArticleСЕРДЕЧНО-ЛЕГОЧНАЯ РЕАНИМАЦИЯCARDIOPULMONARY RESUSCITATIONThrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary ResuscitationThrombolysis for Prevention of Cerebral No-Reflow After Cardiopulmonary ResuscitationHossmannK. -A.HossmannK. -A.hossmann@nf.mpg.deHossmannV.HossmannV.BottigerB. W.BottigerB. W.20092004200952Том V № 2 2009 г.3131Copyright © Hossmann K.-., Hossmann V., Bottiger B.W., 20092009Hossmann K.-., Hossmann V., Bottiger B.W.Hossmann K.-., Hossmann V., Bottiger B.W.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/594

Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the thrombolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiology of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject. 

Thrombolytic treatment during cardiopulmonary resuscitation is thought to reverse the cerebral no-reflow phenomenon which is widely considered to limit neurological recovery after prolonged cardio-circulatory arrest. However, the recent multicenter randomized double-blind TROICA (Thrombolysis in Cardiac Arrest) trial revealed that patients with witnessed out-of-hospital cardiac arrest did not experience an improvement of neurological outcome when treated with the throm-bolytic agent tenecteplase [1]. This raises the question of the importance of coagulation disturbances in the pathophysiol-ogy of no-reflow and its reversal by thrombolytic interventions. This article provides an overview of the experimental literature on this subject.

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The authors declare that there are no conflicts of interest present.