rmtОбщая реаниматологияGeneral Reanimatology1813-97792411-7110FSBI "SRIGR" RAMS10.15360/1813-9779-2008-1-80rmt-829Research ArticleОБЗОРЫ И КРАТКИЕ СООБЩЕНИЯREVIEWS & SHORT COMMUNICATIONSНарушения метаболизма НАД+ в нейрональной дисфункции при критических состоянияхImpaired NAD+ Metabolism in Neuronal Dysfunction in Critical ConditionsСалминаА. Б.SalminaA. V-ФурсовА. А.FursovA. A.-МихуткинаС. В.MikhutkinaS. V-ШахмаеваС. В.ShakhmayevaS. V.-МантороваН. С.MantorovaN. S.-20082002200841Том IV № 1 2008 г.8080Copyright © Салмина А.Б., Фурсов А.А., Михуткина С.В., Шахмаева С.В., Манторова Н.С., 20082008Салмина А.Б., Фурсов А.А., Михуткина С.В., Шахмаева С.В., Манторова Н.С.Salmina A.V., Fursov A.A., Mikhutkina S.V., Shakhmayeva S.V., Mantorova N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.reanimatology.com/rmt/article/view/829

Анализируются современные представления о патогенезе развития нейрональной дисфункции при критических состояниях с позиции нарушений клеточного метаболизма НАД+, активности НАД+-утилизирующих ферментов, в том числе АДФ-рибозилциклазы/€В38, возможности создания новых нейропротективных стратегий. Ключевые слова: нейрональная дисфункция, АДФ-рибозилциклаза /CD38, НАД+, критическое состояние.

The present views of the pathogenesis of neuronal dysfunction in critical conditions are analyzed, by taking into account of impairments of cellular NAD+ metabolism, the activity of NAD+-converting enzymes, including ADP-ribosyl cyclase/CD38, the possibilities of developing new neuroprotective strategies. Key words: neuronal dysfunction, ADP-rybosyl cyclase/CD38, NAD+, critical condition.

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The authors declare that there are no conflicts of interest present.