Preview

General Reanimatology

Advanced search

Proinflammatory Cytokines in Pneumonias of Various Genesis

https://doi.org/10.15360/1813-9779-2007-3-72

Abstract

Objective: to define the diagnostic and prognostic value of the serum levels of proinflammatory cytokines in patients with pneumonia of various genesis. Materials and methods. Enzyme immunoassay was used to investigate proinflammatory cytokines (tumors necrosis factor-a (TNF-a), interleukin(IL)-1a, IL-1/3, IL-6) in the venous blood serum of patients with primary (n=4) and secondary (n=20) pneumonia. Results. Critically patients with pneumonia of various genesis were observed to have statistically significantly higher venous blood TNF-a and IL-6 levels. Primary and secondary pneumonias are characterized by statistically significant differences in the levels of TNF-a and IL-6 within the first 24 hours on day 3 of the patients’ stay in an intensive care unit. In the study group, two subgroups of patients with heterodirectionally and statistically significant changes in the content of all the test cytokines within 1 to 3 days were identified. With a poor outcome of the disease, there was a statistically significant increase in IL-1/8 within the first 24 hours and in TNF-a and IL-6 on day 3. Conclusion. Measurement of proinflammatory cytokines in critically ill patients with pneumonia is of diagnostic and predictive value. Key words: pneumonia, cytokines.

References

1. Чучалина А. Г.

2. Croce M. A., Fabian T. C., SchurrM.J.Using bronhoalveolar lavage to distinguish nosocomial pneumonia from systemic in-flammatory response syndrome: a prospective analysis. J. Trauma 1995; 39 (6): 1134—1139.

3. Balkwwill F.Cytokine сell biology. Oxford: University Press; 2001.

4. Хаитов В. А., Гусев Е. Ю.Иммунология локального и системного воспаления. Аллергология и иммунология 2001; 5: 6—7.

5. Симбирцев А. С.Цитокины — новая система регуляции защитных реакций организма. Цитокины и воспаление 2002; 1 (1): 9—17.

6. Pesci A., Majori M., Caminati A.Bronchoalveolar lavage in intensive care units. Monaldi Arch. Chest Dis. 2004; 61 (1): 39—43.

7. Iregui M., Ward S., Sherman G. et al.Clinical importance of delays in the initation of appropriate antibiotic treatmen for ventilator-associated pneumonia. Chest 2002; 122: 262—268.

8. Tasaka S., Ishizaka A.Pharmacology of acate lung injury. Glea book of intensive care and emergency medicine. Springer; 2005. 73—79.

9. При неблагоприятном исходе заболевания отмечается статистически значимое возрастание в первые сутки IL-1/3, а на третьи сутки — TNF-a и IL-6.

10. Lee Ch., Chang I. J., Yen Z. Sh. 6t al.Delayed fluid resuscitation in hem-orrhagic shok induces proinflammary cytokine response. Ann. Emergency Medicine 2007; 49 (1): 37—44.

11. Strieter R. M., Belperio J. A., Keane M. P.Cytokines in innate host defense in the lung. J.Clin.Invest. 2002; 109: 699—705.

12. Боровик А. В., Руднов В. А.Нозокомиальная пневмония при проведении продленной ИВЛ. Вестн. интенс. терапии 1996; 2—3: 29—33.

13. Блюм Н. Э., Антонов А. Р., Асадуллина Р. Р., Сафронов И. Д.Особенности цитокинового баланса при хронической обструктивной болезни легких. РМЖ. Болезни органов дыхания 2006; 14, 22 (274): 1620—1621.

14. Проценко Д. Н., Ярошецкий А. И., Гельфанд Б. Р., Игнатенко О. В.Значение цитогеногенеза в развитии вентилятор-ассоциированно-го повреждения легких. Вестн. интенс. терапии 2005; 3: 5—10.

15. Martin T. R.Lung cytokines and ARDS: Roger S. Mitehell Lectore. Chest 1999; 116: 2S—8S.


Review

For citations:


Golubev A.M., Smelaya T.V., Moroz V.V., Golubev M.A., Veligan Ye.P., Marsova L.A., Sharshavykh M.V., Lazareva N.M. Proinflammatory Cytokines in Pneumonias of Various Genesis . General Reanimatology. 2007;3(3):72. https://doi.org/10.15360/1813-9779-2007-3-72

Views: 1423


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-9779 (Print)
ISSN 2411-7110 (Online)