Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran
https://doi.org/10.15360/1813-9779-2006-3-12-17
Abstract
Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.
Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.
Results: no-reflow was shown to be caused by pial arteriolar collapse that occurred in ischemia and lasted during reperfusion. Delayed postischemic hypoperfusion was induced by increased pial arteriolar tone.
Conclusion: Intraarterial injection of perfluorane alleviates the manifestation of both phenomena due to better oxygen supply to ischemic brain tissue and, probably, to calcium channel blockage.
About the Authors
V. V. Aleksandrin
Laboratory of Experimental Therapy for Terminal States, Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
V. L. Kozhura
Laboratory of Experimental Therapy for Terminal States, Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
I. S. Novoderzhkina
Laboratory of Experimental Therapy for Terminal States, Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
V. V. Moroz
Laboratory of Experimental Therapy for Terminal States, Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
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Review
For citations:
Aleksandrin V.V., Kozhura V.L., Novoderzhkina I.S., Moroz V.V. Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran. General Reanimatology. 2006;2(3):12-17. (In Russ.) https://doi.org/10.15360/1813-9779-2006-3-12-17
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