New Diagnostic Candidate Molecular Biomarkers of Acute Respiratory Distress Syndrome
https://doi.org/10.15360/1813-9779-2014-4-6-10
Abstract
Editorial dedicated to the development of the algorithm of diagnosis and prognosis of acute respiratory distress syndrome (ARDS), based on the use of recent data (2012—2014) from the V. A. Negovsky Institute of General reanimatology. Modern approaches to the diagnosis and treatment of ARDS are discussed. Available modern data including results of own recent investigation have clearly demonstrated the potential of quantifying surfactant proteins SPA and SPD, which pro duced by cells of the respiratory epithelium, for the early diagnosis and prognosis of ARDS. A new algorithm for diagnosis and prognosis of ARDS based on a sequential quantification of SPA and SPD molecules in the plasma of patients in crit ical conditions is suggested. Circulating SPA and SPD are considered as valuable candidate biomarkers for developing
multiparametric panel of biomarkers for diagnosis and prognosis of ARDS in patients with lifethreatening critical illness.
About the Authors
V. V. Moroz
V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
A. M. Golubev
V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
A. N. Kuzovlev
V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
V. M. Pisarev
V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
References
1. Moroz V.V., Golubev A.M. Klassifikatsiya ostrogo respiratornogo dis tresssindroma. Obshchaya Reanimatologiya. [Classification of acute respiratory distress syndrome. General Reanimatology]. 2007; 3 (5—6): 7—9. [In Russ.]
2. Moroz V.V., Golubev A.M. Printsipy diagnostiki rannikh proyavlenii ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Principles in the diagnosis of early manifestations of acute lung lesion. General Reanimatology]. 2006; 2 (4): 5—7. [In Russ.]
3. Moroz V.V. (red.). Ostryi respiratornyi distresssindrom: klassifikat siya, diagnostika, differentsirovannoe lechenie. Uchebnometodich eskoe posobie. [Acute respiratory distress syndrome: Classification, diagnosis, differentiated treatment. A teaching guide]. Moscow: NIIOR RAMN; 2013: 99. [In Russ.]
4. Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Patogenez i differentsialnaya diagnostika ostrogo respiratornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etiologicheskimi faktorami. Obshchaya Reanimatologiya. [The pathogenesis and differential diagnosis of acute respiratory dis tress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (3): 5—13. [In Russ.]
5. Moroz V.V., Vlasenko A.V., Golubev A.M., Yakovlev V.N., Alekseyev V.G., Bulatov N.N., Smelaya T.V. Differentsirovannoe lechenie ostrogo respira tornogo distresssindroma, obuslovlennogo pryamymi i nepryamymi etio logicheskimi faktorami. Obshchaya Reanimatologiya. [Differentiated treat ment for acute respiratory distress syndrome induced by direct and indirect etiological factors. General Reanimatology]. 2011; 7 (4): 5—15. [In Russ.]
6. Marchenkov Yu.V., Vlasenko A.V., Moroz V.V., Yakovlev V.N. Evolyutsiya diagnostiki i lecheniya ostrogo respiratornogo distress sindroma na osnove noveishikh meditsinskikh tekhnologii. Obshchaya Reanimatologiya. [Evolution of the diagnosis and treatment of acute respiratory distress syndrome on the basis of uptodate medical tech nologies. General Reanimatology]. 2012; 8 (4): 22—30. [In Russ.]
7. Agrawal A., Zhuo H., Brady S., Levitt J., Steingrub J., Siegel M.D., Soto G., Peterson M.W., Chesnutt M.S., Matthay M.A., Liu K.D. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am. J. Physiol. Lung Cell Mol. Physiol. 2012; 303 (8): L634—L639. http://dx.doi.org /10.1152/ajplung.00195.2012. PMID: 22865551
8. Cross L., Matthay M. Biomarkers of acute lung injury: insights into the pathogenesis pf acute lung injury. Crit. Care Clin. 2011; 27 (2): 355—377. http://dx.doi.org/10.1016/j.ccc.2010.12.005. PMID: 21440206
9. Flori H.R., Ware L.B., Glidden D., Matthay M.A. Early elevation of plas ma soluble intercellular adhesion molecule1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr. Crit. Care Med. 2003; 4 (3): 315–321. http://dx.doi.org/10. 1097/01.PCC.0000074583.27727.8E. PMID: 12831413
10. Proudfoot A., Hind M., Griffiths M. Biomarkers of acute lung injury: worth their salt? BMC Med. 2011; 9: 132—140. http://dx.doi.org/10.1186/174170159132. PMID: 22152131
11. Grigoryev Ye.V, Churlyaev Yu.A., Razumov A.S. Biomarkery ostrogo povrezhdeniya legkikh. Obshchaya Reanimatologiya. [Biomarkers of acute lung lesion. General Reanimatology]. 2006; 2 (4): 94—99.
12. Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Shabanov A.K., Golubev М.А. Surfaktantnyi protein D – biomarker ostrogo respira tornogo distresssindroma. Obshchaya Reanimatologiya. [Surfactant protein D is a biomarker of acute respiratory distress syndrome. General Reanimatology]. 2013; 9 (4): 11—18. [In Russ.]
13. Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M., Polovnikov S.G., Shabanov A.K., Golubev М.А. Surfaktantnyi protein A (SPA) – prog nostichesky molekulyarnyi biomarker pri ostrom respiratornom dis tresssindrome. Obshchaya Reanimatologiya. [Surfactant protein A (SPA) is a prognostic molecular biomarker in acute respiratory dis tress syndrome. General Reanimatology]. 2013; 9 (3): 5—13. [In Russ.]
14. Cheng I.W., Ware L.B., Greene K.E., Nuckton T.J., Eisner M.D., Matthay M.A. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003; 31 (1): 20–27. http://dx.doi.org/10.1097/0000324620030100000003. PMID: 12544988
15. Eisner M.D., Parsons P., Matthay M.A., Ware L., Greene K.; Acute Respiratory Distress Syndrome Network. Plasma surfactant protein lev els and clinical outcomes in patients with acute lung injury. Thorax. 2003; 58 (11): 983–988. http://dx.doi.org/10.1136/thorax.58.11.983. PMID: 14586055
16. Ware L.B., Koyama T., Zhao Z., Janz D.R., Wickersham N., Bernard G.R., May A.K., Calfee C.S., Matthay M.A. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit. Care. 2013; 17 (5): R253. PMID: 24156650
Review
For citations:
Moroz V.V., Golubev A.M., Kuzovlev A.N., Pisarev V.M. New Diagnostic Candidate Molecular Biomarkers of Acute Respiratory Distress Syndrome. General Reanimatology. 2014;10(4):6-10. https://doi.org/10.15360/1813-9779-2014-4-6-10
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