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Pathogenetic Role of Cholesterol and Triglyceride Metabolic Disturbances in the Development of Critical Conditions

https://doi.org/10.15360/1813-9779-2015-5-67-74

Abstract

The review considers mechanisms for the development of respiratory failure caused by lipid metabolic disturbances. It gives data on the lung surfactant composition and lipid imbalance in severe concomitant injury, sepsis, and gestosis. Information on the prenatal and postnatal synthesis of triglycerides and cholesterol is detailed. 

About the Authors

S. A. Perepelitsa
V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia 25, Petrovka St., Build. 2, Moscow 107031 Imannuel Kant Baltic Federal University, Kaliningrad, Russia 14, Aleksandr Nevsky St., Kaliningrad 236041
Russian Federation


O. V. Sednev
Imannuel Kant Baltic Federal University, Kaliningrad, Russia 14, Aleksandr Nevsky St., Kaliningrad 236041
Russian Federation


References

1. Khubutiya M.Sh., Romanov A.A., Kurilova O.A., Timerbaev V.Kh., Pervakova E.I., Poplavsky I.V., Levitskaya N.N., Gasanov A.M., Galaiko S.V., Tsurova D.Kh., Golovinsky S.V., Tarabarin E.A. Ranneye ispolzo vanie surfaktanta BL pri transplantatsii legkikh. Obshchaya Reanimatologiya. [Early use of surfactant BL after lung transplanta tion. General Reanimatology]. 2013; 9 (2): 12–17. http://dx.doi.org/ 10.15360/1813 9779 2013 2 12. [In Russ.]

2. Lomivorotov V.V., Efremov S.M., Pokushalov E.A., Romanov A.B., Ponomarev D.N., Chernyavskaya A.M., Shilova A.N. Est li antiaritmich eskie effekty omega 3 polinenasyshchennykh zhirnykh kislot u kar diokhirurgicheskikh bolnykh? Obshchaya Reanimatologiya. [Are there the antiarrhythmic effects of omega 3 polyunsaturated fatty acids in cardiosurgical patients? General Reanimatology] 2014; 10 (5): 33–43. http://dx.doi.org/10.15360/1813 9779 2014 5 33 43. [In Russ.]

3. Perepelitsa S.A., Luchina A.A. Ingalyatsionnaya surfaktant terapiya u novorozhdennykh pri iskusstvennoi ventilyatsii legkikh. Obshchaya Reanimatologiya. [Inhaled surfactant therapy in newborns in artificial lung ventilation. General Reanimatology]. 2014; 10 (5): 44–51. http://dx.doi.org/10.15360/1813 9779 2014 5 44 51. [In Russ.]

4. Rozenberg O.A. Preparaty legochnogo surfactanta pri ostrykh i khronicheskikh zabolevaniyakh legkikh (chast 2). Obshchaya Reanimatologiya. [Pulmonary surfactants for acute and chronic lung diseases (part 2). General Reanimatology]. 2014; 10 (5): 69–86. http://dx.doi.org/10.15360/1813 9779 2014 5 69 86. [In Russ.]

5. Bauer R.R. Surfaktant v neonatologii. Profilaktika i lechenie respira tornogo distress sindroma novorozhdennykh. [Surfactant in neonatol ogy. Prevention and treatment of respiratory distress syndrome in newborn]. Moscow: Meditsinskaya Literatura; 2011: 96. [In Russ.]

6. Phelps D.S. Surfactant regulation of host defense function in the lung: a question of balance. Pediatr. Pathol. Mol. Med. 2001; 20 (4): 269–274. http://dx.doi.org/10.1080/152279501750412225. PMID: 11486734

7. Shabalov N.P. Neonatologiya. t.1. [Neonatology. v.1]. Moscow: MEDpress inform; 2007: 496. [In Russ.]

8. Rozenberg O.A. Preparaty legochnogo surfactanta pri ostrykh i khronicheskikh zabolevaniyakh legkikh (chast 1). Obshchaya Reanimatologiya. [Pulmonary surfactants for acute and chronic lung diseases (part 1). General Reanimatology]. 2014; 10 (4): 51–73. http://dx.doi.org/ 10.15360/1813 9779.2014.10.4.51 73. [In Russ.]

9. Milovanov A.P., Savelyeva S.V. Vnutriutrobnoe razvitie cheloveka. Rukovodstvo dlya vrachei. [Intrauterine human development. Guidelines for physicians]. Moscow: MDV; 2006: 384. [In Russ.]

10. Orgeig S., Daniels C.B., Johnston S.D., Sullivan L.C. The pattern of sur factant cholesterol during vertebrate evolution and development: does ontogeny recapitulate phylogeny? Reprod. Fertil. Dev. 2003; 15 (1–2): 55–73. http://dx.doi.org/10.1071/RD02087. PMID: 12729504

11. Levit A.L., Leiderman I.N., Malkova O.G., Nitenko S.P. Rasstroistva lipidnogo obmena pri tyazhelom sepsise: klinicheskoe znachenie i novye metody korrektsii. Obshchaya Reanimatologiya. [Lipid metabol ic disturbances in severe sepsis: clinical significance and new methods of correction. General Reanimatology]. 2009; 5 (4): 66–74. http://dx.doi.org/10.15360/1813 9779 2009 4 66. [In Russ.]

12. Kuzkov V.V., Fot E.V., Smetkin A.A., Komarov S.A., Kirov M.Yu. Svyaz mezhdu kontsentratsiei triglitseridov plazmy i tyazhestyu ostrogo respiratornogo distress sindroma. Obshchaya Reanimatologiya. [The relation ship between the plasma triglyceride concentration and the severity of acute respiratory distress syndrome. General Reanimatology]. 2012; 8 (1): 22–25. http://dx.doi.org/10.15360/1813 9779 2012 1 22. [In Russ.]

13. Marshall V.J. Klinicheskaya biokhimiya. 6 e izd. [Clinical biochemistry. 6th ed.]. Moscow: BINOM; 2015: 408. [In Russ.]

14. Shcherbakova L.N., Molchanova L.V., Malakhova S.V. Dislipidemiya pri kriticheskikh sostoyaniyakh razlichnoi etiologii. Obshchaya Reanimatologiya. [Dyslipidemia in critical conditions of various etiol ogy. General Reanimatology]. 2008; 4 (1): 36–40. http://dx.doi.org/ 10.15360/1813 9779 2008 1 36. [In Russ.]

15. Malkova O.G., Leiderman I.N., Levit A.L. Izmenenie pokazatelei lipidnogo obmena u bolnykh s tyazhelym sepsisom. [Changes in lipid metabolic parameters in patients with severe sepsis]. Anesteziologiya i Reanimatologiya. 2009; 2: 23–26. PMID: 19514436. [In Russ.]

16. Moroz V.V., Reshetnyak V.I., Muravyeva M.Yu., Zhanataev A.K., Marchenkov Yu.V., Durnev A.D. Obmen kholesterina, DNK povrezh deniya, apoptoz i nekroz kletok v krovi pri tyazheloi sochetannoi travme. Obshchaya Reanimatologiya. [Cholesterol exchange, DNA damages, apoptosis and necrosis of blood cells in severe concomitant injury. General Reanimatology]. 2008; 4 (1): 4–13. http://dx.doi.org/ 10.15360/1813 9779 2008 1 4. [In Russ.]

17. Moroz V.V., Shcherbakova L.N., Nazarov B.F., Galushka S.V., Molchanova L.V. Informativnost biokhimicheskikh pokazatelei plazmy pri gestoza kh. Obshchaya Reanimatologiya. [Information value of biochemical plasma parameters in gestosis. General Reanimatology]. 2005; 1 (4): 6–10. http://dx.doi.org/10.15360/1813 9779 2005 4. [In Russ.]

18. Osochuk S.S., Randarenko I.G., Yarotskaya N.N., Ivanova S.V. Vliyanie anemii na sostav i fiziko khimicheskie svoistva membran eritrotsitov beremennykh zhenshchin. [The impact of anemia on content and phys ical chemical characteristics of membranes of erythrocytes in pregnant women]. Klinicheskaya Laboratornaya Diagnostika. 2013; 6: 20–23. PMID: 24340943. [In Russ.]

19. Whitsett J.A., Weaver T.E. Alveolar development and disease. Am. J. Respir. Cell Mol. Biol. 2015; 53 (1): 1–7. http://dx.doi.org/10.1165/ rcmb.2015 0128PS. PMID: 25932959

20. Danilova L.A. (red.). Vozrastnaya biokhimiya. Uchebnoe posobie. [Age biochemistry. Textbook]. Sankt Peterburg: SOTIS; 2007: 152. [In Russ.]

21. Perepelitsa S.A., Golubev A.M., Moroz V.V. Respiratornyi distress sindrom novorozhdennykh: rannyaya diagnostika, profilaktika, lechenie. Obshchaya Reanimatologiya. [Neonatal respiratory distress syndrome: early diagnosis, prevention, and treatment. General Reanimatology]. 2012; 8 (4): 95–102. http://dx.doi.org/10.15360/1813 9779 2012 4 95. [In Russ.]

22. Hegde S.V., Greenberg B. Newborn respiratory distress: airway abnor malities. Semin. Ultrasound CT MR. 2015; 36 (2): 138–145. http://dx.doi.org/10.1053/j.sult.2015.01.005. PMID: 26001943

23. Lindenskov P.H., Castellheim A., Saugstad O.D., Mollnes T.E. Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies. Neonatology. 2015; 107 (3): 225–230. PMID: 25721501

24. Zhang X., Kiechle F.L. Review: Glycosphingolipids in health and dis ease. Ann. Clin. Lab. Sci. 2004; 34 (1): 3–13. PMID: 15038664

25. Moroz V.V., Golubev A.M., Perepelitsa S.A. Respiratornyi distress sin drom novorozhdennykh. Patogenez, diagnostika, klinika, lechenie. [Neonatal respiratory distress syndrome. Pathogenesis, diagnosis, clin ic, treatment.]. Saarbrücken: Palmarium Academic Publishing; 2014: 126. [In Russ.]

26. Volodin N.N. (red.). Neonatologiya. Natsionalnoe rukovodstvo. [Neonatology. National guide]. Moscow: GEOTAR Media; 2009. [In Russ.]

27. Favrais G., Tourneux P., Lopez E., Durrmeyer X., Gascoin G., Ramful D., Zana Taieb E., Baud O. Impact of common treatments given in the peri natal period on the developing brain. Neonatology. 2014; 106 (3): 163–172. http://dx.doi.org/10.1159/0003634 92. PMID: 25012048

28. Popova A.S., Krupitskaya L.I., Tseilikman V.E., Ryabinin V.E., Sinitsky A.I., Deyev R.V. Sostoyanie energeticheskogo obmena u novorozhden nykh v norme i pri razvitii narushenii adaptatsii v rannem postnatal nom periode. [The energetic metabolism in newborns in normal condi tions and under development of disorders of adaptation in early postnatal period]. Klinicheskaya Laboratornaya Diagnostika. 2013; 1: 22–24. PMID: 23807989. [In Russ.]

29. Chirkin A.A., Danchenko E.O., Bokut S.B. Biokhimiya filogeneza i onto geneza. [Biochemistry of phylogeny and ontogeny]. Minsk: INFRA M; 2012: 288. [In Russ.]


Review

For citations:


Perepelitsa S.A., Sednev O.V. Pathogenetic Role of Cholesterol and Triglyceride Metabolic Disturbances in the Development of Critical Conditions. General Reanimatology. 2015;11(5):67-74. https://doi.org/10.15360/1813-9779-2015-5-67-74

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