PERINATAL TRIGLYCERIDE AND CHOLESTEROL METABOLIC DISTURBANCES IN NEWBORN INFANTS

Objective. Investigate the impact of the course of pregnancy and labor on some lipid metabolic disturbances in newborn infants.

Subjects and methods. The anamnestic data of the course of pregnancy, which were used to identify a high risk for intranatal hypoxia and the birth of a critically ill baby, were analyzed in 217 pregnant women. In addition to assessment of a baby's status at birth, the newborn infants underwent measurements of cholesterol and triglyc-erides in their central venous blood just after birth and on day 5 of life Results. The low levels of triglycerides and cholesterol are an inherent feature in the newborns born via an emergency cesarean section due to bleeding-complicated placental presentation or abruption and other obstetric causes. The most critical plasma level of triglycerides in extremely premature infants born at 22—29 weeks' gestation and in those having extremely low birth weight was no more than 0.01—0.2 mmol/l. Gestational age and birth weight have an impact on the production of triglycerides. Acute intranatal hypoxia affects the perinatal concen-tration of cholesterol in the newborns; the severer is hypoxia, the lower are blood cholesterol levels.

Conclusion. Varying perinatal triglyceride and cholesterol metabolic disturbances are specific in newborn infants with respiratory failure who were born via an emergency cesarean section due to placental abruption or discoordinated labor activity. The low blood levels of the test substances are detectable in babies at birth. Gestational age and birth weight are another factors that influence blood triglyceride concentrations. The lowest triglyceride levels are a characteristic feature in newborn infants at 22—29 weeks' gestation and in those having extremely low birth weight.

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