Early Postnatal Adaptation of a Newborn from a Mother with Type I Diabetes Mellitus
https://doi.org/10.15360/1813-9779-2016-1-43-49
Abstract
Objective: to demonstrate the course of early period of postnatal adaptation of a premature newborn born from a mother with type 1 diabetes mellitus (T1DM), characterized by abnormal glucose and lipid metabolism. Adverse factors included complications during pregnancy.
Conclusion. Medical examination of the newborn born from a mother T1DM included the assessment of glycemic profile and a full evaluation of metabolism, including lipid metabolism. Respiratory therapy was selected based on clinical and laboratory data. The aim of care was normalize the metabolism and eliminate hypoxia and its consequences as soon as possible. The highfrequency oscillatory ventilation was the possible priority in the selection of mechanical ventilation mode, which allowed to quickly eliminate hypoxia. This strategy resulted in reconstitution of spontaneous breathing, the normalization of metabolism and stabilization of the newborn's condition by the end of the early neonatal period.
About the Author
S. A. PerepelitsaRussian Federation
25, Petrovka St., Build. 2, Moscow 107031;
14, Aleksandr Nevsky St., Kaliningrad 236041
References
1. Dedov I.I., Shestakova M.V., Vikulova O.K. Gosudarstvennyi registr sakharnogo diabeta v Rossiiskoi Federatsii: status 2014 goda i perspektivy razvitiya. [Russian Federation State registry of diabetes mellitus: 2014 update and prospects]. Sakharnyi Diabet. 2015; 3: 5—23. [In Russ.]
2. Nold J.L., Georgieff M.K. Infants of diabetic mothers. Pediatr. Clin. North Am. 2004; 51 (3): 619—637. PMID: 15157588
3. Bolotskaya L.K., Efremova N.V., Suntsov Yu.I. Osobennosti techeniya beremennosti u patsientok s debyutom sakharnogo diabeta 1go tipa v prepubertatnyi period. Dannye 15letnego klinicheskogo nablyudeniya. [Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15year long clinical observation]. Sakharnyi Diabet. 2009; 4: 28—31. [In Russ.]
4. Weindling M.A. Offspring of diabetic pregnancy: shortterm outcomes. Semin. Fetal. Neonatal. Med. 2009; 14 (2): 111—118. http://dx.doi.org/10.1016/j.siny.2008.11.007. PMID: 19249005
5. Esayan R.M., Grigoryan O.R., Pekareva E.V. Rol kompensatsii uglevodnogo obmena u beremennykh s sakharnym diabetom 1 tipa v razvitii perinatalnykh oslozhnenii. [The role of compensation of carbohydrate metabolism in pregnant women with type 1 diabetes mellitus in the development of perinatal complications]. Sakharnyi Diabet. 2009;4:23—27. [In Russ.]
6. Shchegolev A.I., Dubova E.A., Pavlov K.A., Esayan R.M., Shestakova M.V., Sukhikh G.T. Sravnitelnaya immunogistokhimicheskaya otsenka faktora rosta endoteliya sosudov i ego retseptorov v vorsinakh platsenty pri gestatsionnom i sakharnom diabete 1 tipa. [Comparative immunohistochemical evaluation of vascular endothelial growth factor and its receptors in the placental villi in gestational diabetes mellitus and type 1 diabetes]. Arkhiv Patologii. 2013; 75 (5): 13—18. PMID: 24341227. [In Russ.]
7. Emmanuilidis G.K., Bailen B.G. Serdechnolegochnyi distress u novorozhdennykh. [Cardiopulmonary distress in newborns]. Moscow: Meditsina Publishers; 1994: 400. [In Russ.]
8. Ikeda H., Shiojima I., Oka T., Yoshida M., Maemura K., Walsh K., Igarashi T., Komuro I. Increased AktmTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice. Mol. Cell Biol. 2011; 31 (5): 1054—1065. http://dx.doi.org/10. 1128/MCB.0073210. PMID: 21189286
9. Dekowski S.A., Snyder J.M. Insulin regulation of messenger ribonucleic acid for the surfactantassociated proteins in human fetal lung in vitro. Endocrinology.1992; 131 (2): 669—676. http://dx.doi.org/10.1210/endo.131.2.1639013. PMID: 1639013
10. Andreyeva T.V. Obsledovanie konechnogo respiratornogo trakta dlya opredeleniya sootvetstviya legkikh sroku gestatsii v perinatalnom periode. Norma. [Examination of the terminal respiratory tract for determining the relationship between the lungs and gestational stage in the perinatal period. Normal conditions]. Arkhiv Patologii. 1994; 56 (2): 69—73. PMID: 8037601. [In Russ.]
11. Mokres L.M., Parai K., Hilgendorff A., Ertsey R., Alvira C.M., Rabinovitch M., Bland R.D. Prolonged mechanical ventilation with air induced apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Am. J. Physiol. Lung Cell Mol. Physiol. 2010; 298 (1): L23—L35. http://dx.doi.org/10.1152/ajplung.00251.2009. PMID: 19854954
12. Potin V.V., Borovik N.V., Tiselko A.V. Insulinoterapiya bolnykh sakharnym diabetom 1go tipa vo vremya beremennosti. [Insulin therapy during pregnancy in women with type 1 diabetes]. Sakharnyi Diabet. 2009; 1: 39—41. [In Russ.]
Review
For citations:
Perepelitsa S.A. Early Postnatal Adaptation of a Newborn from a Mother with Type I Diabetes Mellitus. General Reanimatology. 2016;12(1):43-49. https://doi.org/10.15360/1813-9779-2016-1-43-49