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Impact of Complete Parenteral Nutrition on Metabolic Processes in Cancer Patients in the Early Postoperative Period

https://doi.org/10.15360/1813-9779-2011-2-51

Abstract

Objective: to estimate blood glucose levels during complete parenteral nutrition (CPN), by using the three-in-one system with a high glucose level. Subjects and methods. Thirty adult patients without diabetes mellitus (including 18 men) were examined. Twelve and 18 patients were operated on for colonic and gastric cancers, respectively. CPN (Oliclinomel No. 7 — 1000, 1500 ml; glucose, 240 g in 1500 ml, Baxter, Belgium) was carried out at the Surgery Department in the early postoperative period (3-5 postoperative days) with stable hemodynamics and no organ dysfunction (acute respiratory, renal, hepatic failure). The preparation was administered at a rate of about 83 ml/h over 18 hours. Insulin was not used. Serum glucose concentrations were measured before the study and then for 24 hours at an interval of 6 hours. Results. Glucose concentrations were not found to exceed the allowable values in the majority of patients during CPN at the given rate. In 5 (16.7%) patients, short-term glucose increases up to 13.3 mmol/l were corrected, by decreasing the infusion rate. There was no hypoglycemia or other complications during CPN. Conclusion. Our findings suggest that three-in-one parenteral feeding is safe and causes no metabolic disturbances if simple principles are followed, the basic ones of which are to observe the intake of an adequate total dose and the rate of administration of nutrients. Key words: parenteral feeding, hyperglycemia, metabolic disturbances.

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Obukhova O.A., Kashia Sh.R., Kurmukov I.A., Baikova V.N., Borovkova N.B., Klimanov I.A., Madzhuga A.V. Impact of Complete Parenteral Nutrition on Metabolic Processes in Cancer Patients in the Early Postoperative Period . General Reanimatology. 2011;7(2):51. (In Russ.) https://doi.org/10.15360/1813-9779-2011-2-51

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