Use of Lactoferrin in the Treatment of Patients with Severe Concomitant Injury
https://doi.org/10.15360/1813-9779-2009-5-10
Abstract
Objective: to define the degree of activation of lipid peroxidation in patients with severe concomitant injury and to determine whether they could be corrected with the antioxidant agent Laprot. Subjects and methods. The time course of changes in lipid peroxidation parameters and clinical data was studied in 68 patients with severe concomitant injury, in 35 of whom Laprot (made by P. A. Herzen Moscow Oncological Research Institute, Russian Agency for Medical Technologies (Russia), was added to the standard treatment. Results. The significant activation of oxidative processes and lipid peroxi-dation, which was accompanied by antioxidant system imbalance, was ascertained to occur in severe concomitant injury. Key words: injury, lipid peroxidation, lactoferrin.
References
1. Эделева Н. В., Якубовская Р. И., Осипова Н. А. и соавт.
2. Goode H. F., Cowley H. C., Walker B. E. et al.Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit. Care Med. 1995; 23 (4): 645—651.
3. Borrelli E., Rouz-Lombard P., Grau G. E. et al.Plasma concentrations of cytokins, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit. Care Med. 1996; 24 (3): 392—397.
4. Richard C., Lemonnier F., Thibault M. et al.Vitamin E deficiency and lipoperoxidation during adult respiratory distress syndrome. Crit. Care Med. 1990; 18 (1): 4—9.
5. Пасечник И. Н.Механизмы повреждающего действия активированных форм кислорода на биологические структуры у больных в критических состояниях. Вестн. интенс. терапии 2000; 4: 3—9.
6. McCord J. M.The evolution of free radicals and oxidative stress. Am. J. Med. 2000; 108 (8): 652—659.
7. Cuzzocrea S., Riley D. P., Caputi A. P., Salvemini D.Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 2001; 53 (1): 135—159.
8. Гембицкий Е. В., Клячкин Л. М., Кириллов М. М.Патология внутренних органов при травме. М.: Медицина; 1994.
9. Мороз В. В.Фундаментальные проблемы реаниматологии: Шок. Введение в проблему. Тр. Института общей реаниматологии РАМН. М.; 2003.
10. Зенков Н. К., Ланкин В. З., Меньшикова Е. Б.Окислительный стресс: Биохимический и патофизиологический аспекты. М.: МАИК Наука/Интерпериодика; 2001.
11. Меньшикова Е. Б., Ланкин В. З., Зенков Н. К.Окислительный стресс. Прооксиданты и антиоксиданты. М.: Слово; 2006.
12. Bettering G. I.What is oxidative stress? Metabolism 2000; 49: 3—8.
13. Немцова Е. Р., Уткин М. М., Звягин А. А. и соавт.Антиоксиданты в интенсивной терапии — теория и практика. Роса мед. журнал 2006; 4: 18—22.
14. Lovat R., Preiser J. C.Antioxidant therapy in intensive care. Curr. Opin. Crit. Care. 2003; 9 (4): 266—270.
15. Giladi A. et al.Treatment of acutely injured patients with high-dose anti-oxidantts is associated with a significant reduction in pulmonary failure, catheter-related infections, and abdominal wall complications. J.Am. College Surgeons 2008; 207: 40—41.
16. Остапченко Д. А.Тупая травма груди, как клиническая модель гипоксии смешанного типа: автореф. дисс. … д-ра. мед. наук. М.; 2005.
17. Биленко М. В.Ишемические и реперфузионные повреждения органов. М.: Медицина; 1989.
Review
For citations:
Kapitonov V.M., Ostapchenko D.A., Nemtsova Ye.R. Use of Lactoferrin in the Treatment of Patients with Severe Concomitant Injury . General Reanimatology. 2009;5(5):10. (In Russ.) https://doi.org/10.15360/1813-9779-2009-5-10
Views:
1071
Email this article 