Calcium Metabolic Disturbances in Severe Mechanical Injury in the Presence of Steroid-Induced Osteoporosis: Experimental Study

Abstract

Objective: to reveal the specific features and major mechanisms of development of calcium metabolic disturbances in severe mechanical injury in the presence of steroid-induced osteoporosis. Materials and methods. Experimental studies were performed on 197 albino outbred male rats weighing 250—300 g. The studies used physiological, pathophysiological, X-ray, biochemical studies, enzyme immunoassay, and statistical methods. Results. Calcium metabolic changes in standard mechanical injury depend on the specific features of the body’s individual responsiveness that modulates the course of a posttraumatic reaction and makes up 3 types: non-shock; shock non-fatal, and shock fatal. Osteoporosis aggravates the course of all types of a posttraumatic reaction and reduces the rats’ survival. The new mechanisms responsible for calcium metabolic disturbances, which specify the diagnosis and evaluation of the severity of injury running in the presence of glucocorticoid osteoporosis, are established. Conclusion. The osteoporosis-deteriorated course of a posttraumatic reaction is caused by the mechanism of inadequate bone formation, by relevant parathyroid hormone, thyroid-stimulating hormone, T4, and T3 changes, and hypercytokinemic indices. Key words: severe mechanical injury, glucocorticoid-induced osteoporosis, calcium metabolism, cytokines.