Cardiological Syndrome X: Diagnosis and Intensive Care
https://doi.org/10.15360/1813-9779-2007-4-83-87
Abstract
Objective: to study the efficacy of the atypical neuroleptic sulpiride in the complex intensive therapy for cardialgic syndrome X (CSX).
Subjects and methods. Sixty-six patients with CSX were randomly divided into 2 groups comparable by clinical and history data. Group 1 including 33 patients received traditional intensive antianginal therapy. Group 2 patients were additionally given the atypical neuroleptic sulpiride. The duration of therapy was 4 weeks; thereafter the impact of the therapy performed was evaluated by the time course of changes in anginal symptoms, the frequency of attacks a day, the adaptive capacities of the cardiovascular system, and psychoneurological status.
Results. In Group 2 patients taking sulpiri-de in complex therapy, there were more reductions in the number of anginal attacks, their severity and duration. Pain syndrome relief was achieved in the earlier periods. Sulpiride exerted a positive effect on the patients’ psychoneurological status, which made itself evident in the abolishment of the anxious and depressive manifestations of the disease.
Conclusion. Reduced symptoms and improved adaptive capacities of the cardiovascular system in CSX patients treated with sulfide leads to the conclusion that the drug used in complex and intensive therapy for CSX is a current effective psychocorrect-ing agent that is well tolerated and safe, which promotes the improvement of final treatment Results.
About the Authors
Yu. V. Shirokikh
Department of Anesthesiology and Reanimatology, Institute of Postgraduate Medical Education N. N. Burdenko Voronezh State Medical Academy, Federal Agency for Health Care and Social Development, Voronezh
Voronezh Regional Clinical Hospital One
S. I. Kuznetsov
Department of Anesthesiology and Reanimatology, Institute of Postgraduate Medical Education N. N. Burdenko Voronezh State Medical Academy, Federal Agency for Health Care and Social Development, Voronezh
Voronezh Regional Clinical Hospital One
N. V. Shapovalova
Department of Anesthesiology and Reanimatology, Institute of Postgraduate Medical Education N. N. Burdenko Voronezh State Medical Academy, Federal Agency for Health Care and Social Development, Voronezh
Voronezh Regional Clinical Hospital One
References
1. Григорьянц Р. А. Особенности клиники и течения ишемической болезни сердца у лиц с неизмененными по данным ангиографии коронарными артериями: автореф. дис... д ра мед. наук. М.; 1983.
2. Linkoff W., Segal B. L., Kasparian H. Paradox of normal selective coronary arteriograms in patients considered to have unmistable coronary heart disease. N. Engl. J. Med. 1967; 276: 1063—1066.
3. Kemp H. J., Elliot W. C., Gorlin R. The Anginal Syndrome with normal coronary arteriography. Tras. Ass. Am. Physicians 1967; 80: 59—70.
4. Лавлинская Н. Н., Зыбина И. И., Шанин В. Ю. и др. Кардиалгический синдром Х. Медицинский академический журнал 2003; 3 (2); 74—79.
5. Cannon R. O. , Camici P. G., Epstein S. E. Pathophysiological dilemma of sindrome X. Circulation 1992; 85: 883—892.
6. Костин В. И., Ефремов С. Д., Богданов О. Ю. и др. Особенности коронарной гемодинамики у больных кардиальным синдромом Х. Кардиология 2004; 10: 10—13.
7. Kaski J. C. Pathophysiology and management of patient with chest pain and normal coronary arteriograms (cardiac syndrome X). Circulation 2004; 109: 568—572.
8. Lanza G. A., Pasceri V., Colonna et al. Acute effects of nitrates on exercise testing in patients with syndrome X. Clinical and patophysiologi implications. Am. J. Cardiol. 2004; 79 (9): 1174—1179.
9. Lanza G. A., Pasceri V., Colonna et al. Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X. Am. J. Cardiol. 2002; 84 (7): 854—856.
10. Смулевич А. Б. Депрессии в общемедицинской практике. М.: Медицина; 2000.
11. Маколкин В. И., Ромасенко Л. В. Психосоматические расстройства в клинике внутренних болезней. М.: Медицина; 2003.
12. Смулевич А. Б. Терапия психосоматических расстройств. Клинические эффекты эглонила (сульпирида). Психиатрия и психофармакотерапия 2000; 2 (3): 11—15.
13. Говорин Н. В. Дифференцированная психофармакотерапия при ИБС. Клиническая фармакология и терапия 1997; 6; 63—64.
14. Довгалевский П. Я., Рыбак О. К., Фурман Н. В. Показатели вариабельности сердечного ритма у больных ишемической болезнью сердца в зависимости от тяжести атеросклероза коронарных артерий (по данным коронароангиографии) и функционального класса стенокардии. Кардиология 2004; 9: 17—20.
Review
For citations:
Shirokikh Yu.V., Kuznetsov S.I., Shapovalova N.V. Cardiological Syndrome X: Diagnosis and Intensive Care. General Reanimatology. 2007;3(4):83-87. (In Russ.) https://doi.org/10.15360/1813-9779-2007-4-83-87
Views:
1612
Email this article 