Preview

General Reanimatology

Advanced search

Differential Intensive Therapy for Generalized Peritonitis and Abdominal Sepsis

https://doi.org/10.15360/1813-9779-2005-3-36-40

Abstract

The study was undertaken to substantiate a differential choice of intensive care of abdominal sepsis on the basis of its clinical and pathogenetic types. Clinical and biochemical parameters were retro- and prospectively studied in 60 patients diagnosed as having generalized peritonitis and abdominal sepsis. The patients were divided into 3 groups in accordance with their clinical and pathogenetic characteristics. The clinical and pathogenetic types of the course of abdominal sepsis were identified. The first type required additions of the above complex of intensive care by supplementing enteral detoxification. In the second clinical and pathogenetic type of abdominal sepsis, therapy is extended through simultaneous intravenous administration of perfluorane and enteral detoxification with an enterosorbent. In the third type, therapy is extended through intravenous infusion of perfluorane, followed by enteral detoxification.

About the Authors

Ye. V. Grigoryev
Kemerovo State Medical Academy, Ministry of Health of the Russian Federation, Kemerovo; Branch of the Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Novokuznetsk


Yu. A. Churlyaev
Kemerovo State Medical Academy, Ministry of Health of the Russian Federation, Kemerovo; Branch of the Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Novokuznetsk


References

1. Гельфанд Б. Р., Гологорский В. А., Бурневич С. З., Гельфанд Е. Б. Абдоминальный сепсис: современный взгляд на нестареющую проблему. Анестезиология и реаниматология 1999; 5: 12—15.

2. Шелестюк П. И., Благитко Е. М., Ефремов А. В. Перитонит. Новосибирск: Наука; 2000.

3. Baue A. E., Berlot G., Gullo A. Sepsis and organ dysfunction: Springer; 1998.

4. Hotchkiss R. S., Karl I. E. The pathophysiology and treatment of sepsis. New Engl. J. Med. 2003; 348 (2): 133—148.

5. Russwurm S., Vickers J., MeierZHellman A. Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 2002; 17 (4): 263—268.

6. Казначеев В. П., Дзизинский А. А. Клинические аспекты проблемы проницаемости капилляр-соединительнотканных структур. М: Медицина; 1971.

7. Мишнев О. Д., Щеголев А. И. Печень при эндотоксикозах. М: Издательство РАМН; 2001.

8. Balogh Z., McKinley B. A., Cox C. S. Von Willebrand factor antigen is anindependent marker of poor outcome in patients with early acute lung injury. Shock 2003; 20 (6): 483—492.

9. Ikuta S., Ono S., Kinoshita M. et al. Interleukin 18 concentration in the peritoneal fluid correlates with the severity of peritonitis. Am. J. Surg. 2003; 185 (6): 550—555.

10. Vallet B. Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction. Crit. Care 2003; 7 (3): 130—138.

11. Чурляев Ю. А., Григорьев Е. В., Шерстобитов А. В. и др. Характеристика некоторых компонентов системной воспалительной реакции у больных с распространенным перитонитом. Анестезиология и реаниматология 2003; 3: 25—27.

12. Reinhart K., Bayer O., Brunkhorst F., Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit. Care Med. 2002; 30 (5): S302—S312.

13. Rosenberg R. D., Aird W. C. Vascular-bed specific hemostasis and hypercoagulable states. New Engl. J. Med. 2003; 340 (20): 1555—1564.

14. Бурневич С. З. Энтеральная детоксикация и деконтаминация при распространенном перитоните: автореф… дис. канд. мед. наук. М; 1994.

15. Бассараб Д. А., Кожура В. Л., Голубев А. М. Исследование эффектов перфторана на модели острой интестинальной ишемии. Анестезиология и реаниматология 2002; 6: 31—36.


Review

For citations:


Grigoryev Ye.V., Churlyaev Yu.A. Differential Intensive Therapy for Generalized Peritonitis and Abdominal Sepsis. General Reanimatology. 2005;1(3):36-40. (In Russ.) https://doi.org/10.15360/1813-9779-2005-3-36-40

Views: 1330


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-9779 (Print)
ISSN 2411-7110 (Online)