Role of Plasma D-Dimers in the Diagnosis of Thrombotic Events in Patients with Chronic Coronary Heart Disease
https://doi.org/10.15360/1813-9779-2006-6-66-69
Abstract
Objecive: to estimate hemostatic parameters in 15 cardiosurgical patients with chronic coronary heart disease. Ten parameters of the hemostatic system were determined at 4 stages. The patients were divided into 2 groups in relation to the baseline level of D-dimers. The study demonstrated that hypercoagulation and depressed fibrinolysis retained despite the baseline coagulative potential and the performed therapy in all the patients before discharge. It is obvious that the standard approaches to diagnosing hemostatic disorders and correcting them should be revised.
About the Authors
Yu. V. Nikiforov
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
G. G. Chernysheva
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
O. V. Vukolova
O. M. Filatov City Clinical Hospital No. 15, Moscow
L. V. Molchanova
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow
M. Ye. Yevdokimov
O. M. Filatov City Clinical Hospital No. 15, Moscow
References
1. Donmez A., Aksu K., Celik H. A. et al. Thrombin activable fibrinolysis inhibitor in Bencet's disease. Thrombosis Res. 2005; 115 (4): 287—292.
2. Bauer K. A., Rosendaal F. R., Heit J. A. Hypercoagulability: too many tests, too much conflicting data. Hematology 2002; 1: 353—378.
3. Mills J. D., Mansfield M. W., Grant P. J. Tissue plasminogen activator, fibrin-D-dimer and insulin resistanse in the relatives of patients with premature coronary artery disease. Arterioscler. Thromb. Vascul. Biology 2002; 22: 704—709.
4. Lowe G. D. O., Sweetnam P. M., Garnel J. W. G. et al. C-reactive proteine, fibrin-D-dimer, and risk of ischemic heart disease (The Caerphilly and Speedwell studies). Arterioscl. Vascul. Вiology 2004; 24: 1957—1962.
5. Папаян Л. П., Князева Е. С. D-димер в клинической практике. М.: ООО Инсайт полиграфик; 2002.
6. Тиц Н.У. Энциклопедия клинических лабораторных тестов. М.: Лабинформ; 1997.
7. Эмануэль В. Л., Лаевская Н. Д., Вавилова Т. В. Клиническая лабораторная диагностика: гемограмма и коагулограмма. СПб.; 1996.
8. Хоффманн Ф. Полезные факты о коагуляции. М.: Рош-Москва; 2000.
9. Sandercock P., Gubitz G., Counsell C. Anticoagulants for acute ischemic stroke. Stroke 2004; 35: 2916—2917.
10. Баркаган З. С., Момот А. П. Основные методы лабораторной диагностики нарушений системы гемостаза. Барнаул; 1998.
11. Mohe I., Drouet L., Charsany O. et al. D-dimer: a characteristic of the coagulation sta te of each patient with chronic arterial fibrillation. Thrombosis Res. 2002; 107(1): 1—-6.
12. Angstwurm M. W. A., Reininger A. J., Spannagl M. D-dimer as marker for microcirculatory failure: correlation with LOP and APACHE II scores. Thrombosis Res. 2004; 113 (6): 353—359.
Review
For citations:
Nikiforov Yu.V., Chernysheva G.G., Vukolova O.V., Molchanova L.V., Yevdokimov M.Ye. Role of Plasma D-Dimers in the Diagnosis of Thrombotic Events in Patients with Chronic Coronary Heart Disease. General Reanimatology. 2006;2(6):66-69. (In Russ.) https://doi.org/10.15360/1813-9779-2006-6-66-69
Views:
1030
Email this article 