Preview

General Reanimatology

Advanced search

Comprehensive Measures for Reducing Perinatal Blood Loss

https://doi.org/10.15360/1813-9779-2014-3-15-24

Abstract

Objective: to develop a procedure to reduce perinatal blood loss, by permitting the lower use of allogeneic blood.

Subjects and methods. The investigation enrolled 96 female patients with moderate and severe preeclampsia, whose status was complicated by massive blood loss. The women were divided into 2 groups: a study group (n=55) that was treated by a package of proposed measures and a control group (n=41) that was retrospectively assessed. During the study, the investigators made a dynamic assessment of peripheral blood parameters and hemostatic system markers, monitored blood and central venous pressures, hourly and daily diuresis, acid base and water electrolyte balance parameters, and collected medical history data.

Results. The investigation established that a package of proposed measures to reduce massive obstetric blood loss significantly accelerated the restoration of general clinical and biochemical parameters in the early postoperative period.

Conclusion. The proposed procedure is easy-to-use and it is of obvious practical use because it can reduce the use of donor blood components by twice and the length of hospital stay by 6. 5 bed-days. 

About the Authors

S. Yu. Timokhova
Kuban State Medical University, Krasnodar Krasnodar Regional Clinical Hospital Two, Krasnodar
Russian Federation
Department of Anesthesiology, Intensive Care and Transfusiology, Faculty for Advanced Training and Occupational Retraining    


V. V. Golubtsov
Kuban State Medical University, Krasnodar Krasnodar Regional Clinical Hospital Two, Krasnodar
Russian Federation
Department of Anesthesiology, Intensive Care and Transfusiology, Faculty for Advanced Training and Occupational Retraining    


References

1. Gerasimov L.V., Samorukov V.Yu., Moroz V.V., Ivanova G.P. Primenenie eritropoetina u bolnykh s travmoi i krovopoterei. Obshchaya Reanimatologiya. [Use of erythropoietin in patients with injury and blood loss. General Reanimatology]. 2012; 8 (5): 11—18. [In Russ.]

2. Podolsky Yu.S. Osobennosti patogeneza i korrektsii kriticheskikh sostoyanii v akusherstve. Obshchaya Reanimatologiya. [The specific features of the pathogenesis and correction of critical conditions in obstetric care. General Reanimatology]. 2012; 8 (4): 103—110. [In Russ.]

3. Borisov K.Yu., Moroz V.V., Grebenchikov O.A., Plotnikov E.Yu., Levikov D.I., Cherpakov R.A., Likhvantsev V.V. Vliyanie propofola na anesteticheskoe prekonditsionirovanie miokarda sevofluranom v eksperimente. Obshchaya Reanimatologiya. [Effect of propofol on sevoflurane-induced myocardial preconditioning in the experiment. General Reanimatology]. 2013; 9 (4): 30—35. [In Russ.]

4. Borovkova N.V., Valetova V.V., Timerbayev V.Kh., Kazakov M.G., Nikitina O.V., Khvatov V.B. Reaktsiya leikotsitov i apoptoz limfotsitov perifericheskoi venoznoi krovi kak marker tkanevoi ishemii pri ostroi massivnoi krovopotere. Obshchaya Reanimatologiya. [Leukocytic response and peripheral venous blood lymphocyte apoptosis as a marker of tissue ischemia in acute massive blood loss. General Reanimatology]. 2013; 9 (4): 18—22. [In Russ.]

5. Filatov V.V., Dolgikh V.T. Osobennosti gemodinamiki i svertyvayushchei sistemy krovi u bolnykh, operirovannykh po povodu krovotechenii yazvennoi bolezni. Obshchaya Reanimatologiya. [Hemodynamics and blood coagulation system in patients operated following ulcer disease hemorrhagia. General Reanimatology]. 2013; 9 (3): 30—34. [In Russ.]

6. Yakovlev A.Yu., Kichin V.V., Nikolsky V.O., Kalentyev G.V., Ryabikov D.V., Ryabikova M.A., Protasov D.M., Galanina T.A., Smorkalov A.Yu., Evdokimova O.S. Effektivnost primeneniya sterofundina izotonicheskogo posle ostroi massivnoi krovopoteri v eksperimente. Obshchaya Reanimatologiya. [Efficacy of employment of isotonic sterofundin after experimental hemorrhagic shock. General Reanimatology]. 2013; 9 (3): 24—29. [In Russ.]

7. Shen N.P., Kukarskaya I.I., Shvechkova M.V. Ostraya massivnaya krovopoterya v akusherstve: est li perspektivy sokratit obyem? [Acute massive blood loss in obstetrics: are there promises to reduce its volume?] Vestnik Intensivnoi Terapii. 2013; 2: 43—49. [In Russ.]

8. Ailamazyan E.K., Kulakov V.I., Radzinsky V.E., Savelyeva G.M. Akusherstvo. Natsionalnoe rukovodstvo. [Obstetrics. National Guidelines]. Moscow: GEOTAR-Media; 2009: 1200. [In Russ.]

9. Vorobyev A.I., Gorodetsky V.M., Shulutko E.M. Ostraya massivnaya krovopoterya. [Acute massive blood loss]. Moscow: GEOTAR-Media; 2001: 340. [In Russ.]

10. Dementyeva I.I., Charnaya M.A., Morozov Yu.A. Patologiya sistemy gemostaza. [Pathology of the hemostatic system]. Moscow: GEOTAR-Media; 2011: 283. [In Russ.]

11. Gelfand B.R., Saltanov A.I. (red.). Intensivnaya terapiya. Natsionalnoe rukovodstvo. t.1,2. [Intensive therapy. National Guidelines. vol. 1,2]. Moscow: GEOTAR-Media; 2009: 784. [In Russ.]

12. Lantsev E.A., Abramchenko V.V. Anesteziya, intensivnaya terapiya i reanimatsiya v akusherstve. [Anesthesia, intensive therapy, and intensive care in obstetrics]. Moscow: MEDpress-Inform; 2011: 623. [In Russ.]

13. Malyshev V.D., Sviridov S.V. Intensivnaya terapiya. [Intensive therapy]. Moscow: Meditsinskoe Informatsionnoe Agentstvo; 2009: 705. [In Russ.]

14. Makatsariya A.D., Bitsadze O.V. Trombofilin i protivotromboticheskaya terapiya v akusherskoi praktike. [Thrombophilias and antithrombotic therapy in obstetric practice]. Moscow: Triada — X; 2003: 903. [In Russ.]

15. Makatsariya A.D., Bitsadze O.V., Akinshina S.V. Trombozy i tromboembolii v akusherskoginekologicheskoi klinike. [Thromboses and thrombophilias in obstetric/gynecological clinical practice]. Moscow: Meditsinskoe Informatsionnoe Agentstvo; 2007: 1064. [In Russ.]

16. Zabolotskikh I.B., Sinkov S.V., Shaposhnikov S.A. Diagnostika i korrektsiya rasstroistv sistemy gemostaza. [Diagnosis and correction of hemostatic system disorders]. Moscow: Prakticheskaya Meditsina; 2008: 331. [In Russ.]

17. Serov V.N., Sukhikh G.T., Baranov I.I., Pyregov A.V., Tyutyunnik V.L., Shmakov R.G. Neotlozhnye sostoyaniya v akusherstve. [Emergencies in obstetrics]. Moscow: GEOTAR-Media; 2011: 784. [In Russ.]

18. Kozek-Langenecker S.A., Afshari A., Albaladejo P., Santullano C.A., De Robertis E., Filipescu D.C., Fries D., Görlinger K., Haas T., Imberger G., Jacob M., Lancé M., Llau J., Mallett S., Meier J., Rahe-Meyer N., Samama C.M., Smith A., Solomon C., Van der Linden P., Wikkelsø A.J., Wouters P., Wyffels P. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur. J. Anestesiol. 2013; 30 (6): 270—382. http://dx.doi.org/10.1097/EJA.0b013e32835f4d5b. PMID: 23656742

19. Carvalho A. Hematologic pathophysiology. 2009; 446.

20. Brenner B. Haemostatic changes in pregnancy. Thromb. Res. 2004; 114 (5—6): 409—414. http://dx.doi.org/10.1016/j.thromres.2004.08.004. PMID: 15507271

21. Sukhikh G.T., Serov V.N., Savelyeva G.M. Profilaktika i terapiya massivnoi krovopoteri v akusherstve. [Prevention and therapy of massive blood loss in obstetrics]. Moscow: Meditsinskaya Tekhnologiya; 2010: 20. [In Russ.]

22. Ministerstvo zdravookhraneniya RF. Prikaz No183-n «Ob utverzhdenii pravil klinicheskogo ispolzovaniya donorskoi krovi i (ili) ee komponentov» ot 2 aprelya 2013 g. [Ministry of Health of the Russian Federation. Order No. 183-n «On approval of the rules of clinical application of donor blood and/or its components» dated 2 April 2013]. [In Russ.]

23. Muzychenko V.P., Timokhova S.Yu., Kapushchenko I.N., Sinkov S.V., Zabolotskikh I.B. Struktura narushenii gemostaza u beremennykh s gestozom. [Pattern of hemostatic disorders in pregnant women with gestosis]. Kubansky Nauchnyi Meditsinsky Vestnik. 2011; 5 (128): 99— 102. [In Russ.]

24. Muzychenko V.P., Timokhova S.Yu., Zabolotskikh I.B., Golubtsov V.V., Grigoryev S.V. Sostoyanie sistemy gemostaza v usloviyakh razlichnykh vidov anestezii pri rodorazreshenii u beremennykh s gestozami. [The hemostatic system in pregnant women with gestosis during delivery under different modes of anest]. Vestnik Intensivnoi Terapii. 2012; 5: 93—101. [In Russ.]

25. Tumanyan S.V., Sidko D.V., Surovtsev R.F. Korrektsiya massivnykh krovotechenii pri tyazhelykh formakh gestoza. Obshchaya Reanimatologiya. [Correction of massive bleeding in severe forms of gestosis. General Reanimatology]. 2005; 1 (3): 25—31. [In Russ.]

26. Bulanov A.Yu., Shulutko E.M., Sinauridze E., Vasilyev S.A., Gorbatenko A.S. Gemodilyutsiya i gemodilyutsionnaya koagulopatiya. [Hemodilution and hemodilution coagulopathy]. Terapevtichesky Arkhiv. 2006; 78 (7): 90—94. PMID: 16944759. [In Russ.]


Review

For citations:


Timokhova S., Golubtsov V. Comprehensive Measures for Reducing Perinatal Blood Loss. General Reanimatology. 2014;10(3):15-24. https://doi.org/10.15360/1813-9779-2014-3-15-24

Views: 1196


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1813-9779 (Print)
ISSN 2411-7110 (Online)