РОЛЬ СУКЦИНАТОВ ПРИ КРИТИЧЕСКИХ СОСТОЯНИЯХ
https://doi.org/10.15360/1813-9779-2014-6-65-82
Аннотация
В обзоре литературы отражен современный взгляд на патофизиологические механизмы развития митохондриальной дисфункции при гипоксии критических состояний. Отмечена роль сукцинатов в развитии митохондриальной дисфункции, последующих органных расстройств и полиорганной недостаточности при различной патологии в период срочной адаптации к гипоксии, которая осуществляется за счет мобилизации энергоресурсов: их централизации, интенсификации катаболизма углеводов, жиров и белков, а также подавления анаболических процессов в тканях. Механизм срочной адаптации к гипоксии при критических состояниях развивается с характерным уменьшением количества сукцината (субстрата для фермента), что позволяет проводить коррекцию его дефицита с перспективой увеличения потребления кислорода, активации процессов аэробного окисления и восстановления процессов внутриклеточного аэробного метаболизма.
Об авторах
Ю. П. Орлов
Омская государственная медицинская академия Министерства здравоохранения России, Омск, Россия 644043, Омск, ул. Ленина, д. 12
Россия
Россия
Н. В. Говорова
Омская государственная медицинская академия Министерства здравоохранения России, Омск, Россия 644043, Омск, ул. Ленина, д. 12
Россия
Россия
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Рецензия
Для цитирования:
Орлов Ю.П., Говорова Н.В. РОЛЬ СУКЦИНАТОВ ПРИ КРИТИЧЕСКИХ СОСТОЯНИЯХ. Общая реаниматология. 2014;10(6):65-82. https://doi.org/10.15360/1813-9779-2014-6-65-82
For citation:
Orlov Yu.P., Govorova N.V. Role of Succinates in Critical Conditions. General Reanimatology. 2014;10(6):65-82. https://doi.org/10.15360/1813-9779-2014-6-65-82
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