SUCCESSFUL TREATMENT FOR ATYPICAL HEMOLYTIC UREMIC SYNDROME IN A PUERPERA
https://doi.org/10.15360/1813-9779-2015-6-61-68
Abstract
Objective: to show the problems of differential diagnosis and treatment of atypical hemolytic-uremic syndrome in a 23-year-old patient.
Results. Eculizumab (Soliris), (Alexon Pharmaceuticals Inc., USA) that is a glycosylated humanized monoclonal antibody to immunoglobulins (IgG2/4k) is shown to be effective in treating this disease.
Conclusion. Atypical hemolytical-uremic syndrome in pregnancy is a disease, whose treatment difficulties are largely associated with the problem of differential diagnosis with thrombotic thrombocytopenic purpura and man-ifestations of multiple organ dysfunction. The treatment for this disease gives a key role to Eculizumab.
About the Authors
O. N. Ulitkina
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
Zh. S. Filippovskaya
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
E. I. Prokopenko
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
A. M. Ovezov
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
V. V. Likhvantsev
M. F. Vladimirsky Moscow Regional Research Clinical Institute
V. A. Negovsky Research Institute of General Reanimatology
Russian Federation
Russian Federation
61/2, Shchepkin St., Moscow 129110, Russia
25, Petrovka St, Build. 2, Moscow 107031, Russia
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Review
For citations:
Ulitkina O.N., Filippovskaya Zh.S., Prokopenko E.I., Ovezov A.M., Likhvantsev V.V. SUCCESSFUL TREATMENT FOR ATYPICAL HEMOLYTIC UREMIC SYNDROME IN A PUERPERA. General Reanimatology. 2015;11(6):61-68. https://doi.org/10.15360/1813-9779-2015-6-61-68
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