Role of Secondary Brain Damage Factors in Activation of VascularPlatelet Hemostasis in Traumatic Brain Injury
https://doi.org/10.15360/1813-9779-2016-5-42-51
Abstract
Purpose of the study. To evaluate the role of secondary brain damage factors in activation of vascularplatelet hemostasis in traumatic brain injury (TBI).
Material and methods. In the ICU, 30 patients with complex traumatic brain injury were examined and treated. In the posttraumatic period, in patient measurement of heart and vascular tone, platelets, hemoglobin, lactate, and active forms of oxygen in the blood were investigated.
The study results have showed that damaged brain secondary factors accompanying concomitant TBI (circulatory insufficiency, hypoxia, acidosis and increased free radical formation) represent at the same time nonspecificstimuli for platelets and cells of blood vessels that consequently, cause systemic activation of the vascularplatelet link within the hemostasis system.
Conclusion. Nonspecific systemic activation of the vascularplatelet hemostasis by secondary factors in the patients with concomitant TBI is one of pathogenetic components of ischemic brain damage.
About the Authors
G. A. Boyarinov
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
L. V. Boyarinova
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
A. V. Deryugina
N. I. Lobachevsky Nizhny Novgorod National Research State University
Russian Federation
23, Gagarin Av., Nizhny Novgorod GSP20, 603950, Russia
Russian Federation
23, Gagarin Av., Nizhny Novgorod GSP20, 603950, Russia
O. D. Solov'eva
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
R. R. Zaytsev
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
O. V. Voyennov
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
E. V. Moshnina
Nizhny Novgorod State Medical Academy, Ministry of Health of Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
Russian Federation
10/1, Minin and Pozharsky Sq., Nizhny Novgorod GSP470, 603950, Russia
A. V. Shumilova
N. I. Lobachevsky Nizhny Novgorod National Research State University
Russian Federation
23, Gagarin Av., Nizhny Novgorod GSP20, 603950, Russia
Russian Federation
23, Gagarin Av., Nizhny Novgorod GSP20, 603950, Russia
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Review
For citations:
Boyarinov G.A., Boyarinova L.V., Deryugina A.V., Solov'eva O.D., Zaytsev R.R., Voyennov O.V., Moshnina E.V., Shumilova A.V. Role of Secondary Brain Damage Factors in Activation of VascularPlatelet Hemostasis in Traumatic Brain Injury. General Reanimatology. 2016;12(5):42-51. (In Russ.) https://doi.org/10.15360/1813-9779-2016-5-42-51
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