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Сорбенты для экстракорпорального удаления токсических веществ и молекул с нежелательной биологической активностью (обзор)

https://doi.org/10.15360/1813-9779-2016-6-82-107

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Аннотация

В обзоре рассмотрены сорбенты и медицинские изделия на их основе, применяемые в клинической практике для экстракорпоральной детоксикации с помощью процедуры гемосорбции. Представлены данные исследователей, свидетельствующие об эффективности такого подхода с целью удаления бактериальных эндотоксинов, липопротеинов низкой плотности, билирубина, а также при лечении аутоиммунных заболеваний. Основное внимание уделено применению гемосорбции при лечении тяжелого сепсиса и септического шока. Обосновывается необходимость разработки и применения новых «мультимодальных» сорбентов, сочетающих свойства как «селективных», так и «неселективных» сорбентов. В обзоре приведены сведения о клинической эффективности гемосорбции и молекулярном взаимодействии сорбента с циркулирующими молекулами, патогенетически значимыми для развития критических состояний и тяжелых заболеваний. Библиография — 137 ссылок.

Об авторах

А. С. Морозов
АО Перспективные медицинские технологии
Россия
107045, г. Москва, Луков пер., д. 4, оф. 8


И. В. Бессонов
АО Перспективные медицинские технологии
Россия
107045, г. Москва, Луков пер., д. 4, оф. 8


А. В. Нуждина
Московский государственный технический университет им. Н. Э. Баумана
Россия
105005, г. Москва, 2-я Бауманская ул., д. 5, стр. 1


В. М. Писарев
НИИ общей реаниматологии им. В. А. Неговского
Россия
107031, г. Москва, ул. Петровка, д. 25, стр. 2


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Для цитирования:


Морозов А.С., Бессонов И.В., Нуждина А.В., Писарев В.М. Сорбенты для экстракорпорального удаления токсических веществ и молекул с нежелательной биологической активностью (обзор). Общая реаниматология. 2016;12(6):82-107. https://doi.org/10.15360/1813-9779-2016-6-82-107

For citation:


Morozov A.S., Bessonov I.V., Nuzhdina A.V., Pisarev V.M. Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review). General Reanimatology. 2016;12(6):82-107. (In Russ.) https://doi.org/10.15360/1813-9779-2016-6-82-107

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