Новые методы лечения при сепсисе: модели на животных «не работают» (обзор)
https://doi.org/10.15360/1813-9779-2018-3-46-53
Аннотация
Сепсис, как и многие патологические инфекционные процессы, в основном изучается in vivo с использованием моделей на мышах. За последние 30 лет подобные исследования привели к значимым достижениям в понимании патофизиопатологии сепсиса. Однако, к сожалению, ни одно из них не привело к каким-либо «открытиям» в терапии пациентов. В настоящем обзоре мы ставим под сомнение актуальность используемых экспериментальных моделей, перечислим некоторые из редко принимаемых во внимание аспектов и обсудим пути выхода из создавшегося тупика. Ключевые слова: модели на животных; лечение сепсиса
Текст является переводом статьи Cavaillon J. M. Nouvelles therapies du sepsis: l'echec des modeles animaux, Bull. Assoc. Anc. El. Inst. Pasteur, 2017, 59, 230, 58—60. Перевод с французского выполнен фирмой «Академперевод», Москва, Россия.
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Рецензия
Для цитирования:
Кавайон Ж. Новые методы лечения при сепсисе: модели на животных «не работают» (обзор). Общая реаниматология. 2018;14(3):46-53. https://doi.org/10.15360/1813-9779-2018-3-46-53
For citation:
Cavaillon J. New Approaches to Treat Sepsis: Animal Models «Do Not Work» (Review). General Reanimatology. 2018;14(3):46-53. https://doi.org/10.15360/1813-9779-2018-3-46-53
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