Neuroprotection Mechanisms in Cerebral Hypothermia (Review)
https://doi.org/10.15360/1813-9779-2019-6-94-114
Abstract
The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.
The concept of hypothermic pre-conditioning based on the development of typical nonspecific reactions for the formation of the cytoprotective phenotype of neurons due to potentially dangerous stimuli, such as ischemia, reperfusion, and hypothermia, was used to explain the effects of low temperatures. The data confirming the role of therapeutic cerebral hypothermia as a technique of selective brain exposure to mild cold for the neuroprotection and correction of temperature balance disorders are shown.
The approach to therapeutic hypothermia as a hypothermic pre-conditioning allows to significantly expand the scope of its use in various procedural variants.
About the Authors
Oleg A. Shevelev
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology;
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
777 Lytkino 141534, Solnechnogorsk district, Moscow region;
6 Miklukho-Maсlaya Str., 117198 Moscow
Marina V. Petrova
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology;
Peoples’ Friendship University of Russia
Russian Federation
777 Lytkino 141534, Solnechnogorsk district, Moscow region;
6 Miklukho-Maсlaya Str., 117198 Moscow
Russian Federation
777 Lytkino 141534, Solnechnogorsk district, Moscow region;
6 Miklukho-Maсlaya Str., 117198 Moscow
Shavkat Kh. Saidov
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Russian Federation
777 Lytkino 141534, Solnechnogorsk district, Moscow region
Russian Federation
777 Lytkino 141534, Solnechnogorsk district, Moscow region
Nadezhda A. Khodorovich
Peoples’ Friendship University of Russia
Russian Federation
6 Miklukho-Maсlaya Str., 117198 Moscow
Russian Federation
6 Miklukho-Maсlaya Str., 117198 Moscow
Pranil Pradkhan
2 Peoples’ Friendship University of Russia
Nepal
6 Miklukho-Maсlaya Str., 117198 Moscow
Nepal
6 Miklukho-Maсlaya Str., 117198 Moscow
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Review
For citations:
Shevelev O.A., Petrova M.V., Saidov Sh.Kh., Khodorovich N.A., Pradkhan P. Neuroprotection Mechanisms in Cerebral Hypothermia (Review). General Reanimatology. 2019;15(6):94-114. https://doi.org/10.15360/1813-9779-2019-6-94-114
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