Effect of NaCl/Hydroxyethyl Starch 200/0.5 on Lung Function and Hemodynamics in Patients Operated on under Extracorporeal Circulation
https://doi.org/10.15360/1813-9779-2012-5-38
Abstract
Objective: to study the effect of 7.2% NaCl/hydroxyethyl starch 200/0.5 on extravascular lung water and respiratory and cardiovascular systems in patients with coronary heart disease (CHD) after myocardial revascularization under extracorporeal circulation (EC). Subjects and methods. A prospective, randomized study was conducted in 40 patients with coronary artery disease. A study group (n=20) received 7.2% NaCl/hydroxyethyl starch 200/0.5; a control group (n=20) had 0.9% NaCl in a dose of 4 ml/kg within 30 min before EC. Extravascular lung water and central hemodynamic parameters were assessed using transpulmonary thermodilution and a Swan-Ganz catheter; respiratory function was estimated by the arterial oxygenation index, alveolar-arterial oxygen tension difference, and venous shunt fraction. Plasma osmolality and Na concentration were determined using an Osmomat 030 device. Conclusion. The intraoperative use of 7.2% NaCl/hydroxyethyl starch 200/0.5 in patients with CHD leads to a significant reduction in extravascular lung water after myocardial revascularization, thereby effectively protecting pulmonary oxygenizing function. The single administration of 7.2% NaCl/hydroxyethyl starch causes a short-term increase in cardiac index and it is a relatively safe in preventing neurological disorders and heart failure. Key words: 7.2% NaCl/hydroxyethyl starch 200/0.5; extravascular lung water, respiratory function, cardiac index, osmolarity.
About the Authors
V. V. LomivorotovE. V. Fominsky
V. A. Nepomnyashchikh
S. M, Efremov
A. M. Chernyavsky
V. N. Lomivorotov
A. N. Shilova
A. M. Karaskov
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For citations:
Lomivorotov V.V., Fominsky E.V., Nepomnyashchikh V.A., Efremov S.M., Chernyavsky A.M., Lomivorotov V.N., Shilova A.N., Karaskov A.M. Effect of NaCl/Hydroxyethyl Starch 200/0.5 on Lung Function and Hemodynamics in Patients Operated on under Extracorporeal Circulation . General Reanimatology. 2012;8(5):38. (In Russ.) https://doi.org/10.15360/1813-9779-2012-5-38
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