Lung Morphological Changes in Closed Chest Injury (an experimental study)
https://doi.org/10.15360/1813-9779-2012-2-11
Abstract
Objective: to study lung morphological changes in a closed chest injury model in laboratory animals. Material and methods. Experiments were carried out in 30 male albino nonbred rats weighing 350—380 g. Closed chest injury was simulated, by exposing the chest of anesthetized rats to a 300-g metal cylinder falling from a height of 30 cm. The observation periods were 1, 3, 6, and 24 hours. Results. The signs of evident perivenular edema that was uncharas-teristic to acute respiratory distress syndrome induced by other causes are an important peculiarity of lung morphological changes in this experimental model of closed chest injury. Conclusion. The experimental studies clarified the pattern of lung morphological changes in the early period after closed chest injury. Key words: closed chest injury, pulmonary edema.
About the Authors
A. M. GolubevE. M. Antoshina
Yu. V., Marchenkov
V. V. Moroz
A. N. Kuzovlev
D. V. Sundukov
References
1. Мороз В. В., Власенко А. В., Голубев А. М. и соавт.
2. Raghavendran K., Davidson B. A., Hutson A. D. et al.Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration. J. Trauma 2009; 67 (6): 1182—1190.
3. Cohn S. M., Dubose J. J.Pulmonary contusion: an update on recent advances in clinical management. World J. Surg. 2010; 34 (8): 1959—1970.
4. Wang N. D., Stevens M. H., Doty D. B., Hammond E. H.Blunt chest trauma: an experimental model for heart and lung contusion. J. Trauma 2003; 54 (4): 744—748.
5. Мороз В. В., Голубев А. М., Марченков Ю. В. и соавт.Морфологические признаки острого повреждения легких различной этиологии (экспериментальное исследование). Общая реаниматология 2010; VI (3): 29—34.
6. Mastroroberto P., Di Mizio G., Colosimo F., Ricci P.Occlusion of left and right coronary arteries and coronary sinus following blunt chest trauma. J. Forensic. Sci. 2011; 56 (5): 1349—1351.
7. Closey D. N., Long G., Lin Z. et al.Isolated ventricular septal defect secondary to low-velocity blunt chest trauma. Crit. Care Resusc. 2001; 3 (2): 95—96.
8. Vougiouklakis T., Peschos D., Doulis A. et al.Injury. Sudden death from contusion of the right atrium after blunt chest trauma: case report and review of the literature. Injury 2005; 36 (1): 213—217.
Review
For citations:
Golubev A.M., Antoshina E.M., Marchenkov Yu.V., Moroz V.V., Kuzovlev A.N., Sundukov D.V. Lung Morphological Changes in Closed Chest Injury (an experimental study) . General Reanimatology. 2012;8(2):11. (In Russ.) https://doi.org/10.15360/1813-9779-2012-2-11
Views:
1245
Email this article 