Genetic Polymorphism and the Rate of Development of Complications in Pneumonia of Varying Genesis
https://doi.org/10.15360/1813-9779-2011-2-10
Abstract
Objective: to study the genetic polymorphism of the genes of phase I and II xenobiotic detoxification (GSTM1, GSTP1, GSTT1, CYP1A1), as well as ACE, CCR5, MTHFR, and those of the cytokines IL-6 and TNF-a to reveal hereditary predisposition to pneumonia of varying genesis and its complications. Materials and methods. The frequency of the allele variants of 7 genes was studied in the groups of patients with pneumonia (n=524) and healthy donors (a control group (n=178). Results. There were are genotypes associated with predisposition to community-acquired and nosocomial pneumonia (CAP and NP): GSTM I*, CYP1A1 606T/T, ACE D/D and those associated with a higher risk for complicated CAP. There were effects of the allelic variants of the ACE gene in developing complications, such as acute respiratory distress syndrome, multiple organ dysfunction, and sepsis: ACEI/I insertion homozygotes linked to survival and the alternative ACE D/D genotype to mortality. Conclusion: The study revealed an association of detoxification gene polymorphism with predisposition to CAP and NP and with the development of complications in CAP. Key words: xenobiotic detoxification genes, key ACE renin-angiotensin system gene, chemokine receptor 5 (CCR5) gene, pneumonia, acute respiratory distress syndrome, sepsis, multiple organ dysfunction.
About the Authors
T. V. SmelayaL. Ye. Salnikova
V. V. Moroz
A. M., Golubev
Yu. V. Zarzhetsky
A. V. Rubanovich
References
1.
2. Сеитова Г. Н, Буйкин С. В., Рудко А. А., Фрейдин М. Б.Наследственность и болезни легких (Наследственность и здоровье), Учебное пособие. Пузырев В. П. (ред.). Томск: Печатная мануфактура; 2008.
3. Lockwood W. W, Chari R, Chi B, Lam W. L.Recent advances in array comparative genomic hybridization technologies and their applications in human genetics. Eur. J. Hum. Genet. 2006; 14 (2): 139—148.
4. Pugin J, Auckenthaler R, Mili N. et al.Diagnosis of ventilator-associated pneumonia by bacteriological analysis of bronchoscopic and non bronchoscopic «blind» bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 1991; 143 (5Pt 1): 1121 — 1129.
5. Сальникова Л. Е, Фомин Д. К, Елисова Т. В. и соавт.Изучение связи цитогенетических и эпидемиологических показателей с генотипами у ликвидаторов последствий аварии на ЧАЭС. Радиационная биология. Радиология 2008; 48 (3): 303-312.
6. Электронная ссылка программы Primer3 [http://frodo.wi.mit.edu/primer3/].
7. Электронная ссылка (трендовый тест Армитажа) [http://www.bio-medcentral.com/1753-6561/3/S7/S37].
8. Электронная ссылка on-line программы SNPStats [http://bioinfo. iconcologia.net].
9. Сальникова Л. Е., Смелая Т. В., Мороз В. В. и соавт.Генетическая предрасположенность к развитию острой внебольничной пневмонии. Общая реаниматология 2010; VI (1): 5—11.
10. Баранов В. С., Баранова Е. В., Иващенко Т. Э., Асеев М. В.Геном человека и гены «предрасположенности». Введение в предиктивную медицину. СПб.: Интермедика; 2000.
11. Ivaschenko T., Sideleva O., Baranov V.Glutathione-S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J. Mol. Med. 2002; 80 (1): 39-43.
12. Kirsch-Volders M., Mateuca R. A., Roelants M. et al.The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo. Cancer Epidemiol. Biomarkers Prev. 2006; 15 (5): 1038—1042.
13. СальниковаЛ. Е., ИвановаТ. И., КондрашоваТ. В. исоавт.GSTM1: иметь или не иметь? Технологии живых систем 2009; 2: 31—38.
14. Rotunno M., Yu K., LubinJ. H. et al.Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. PLоS One 2009; 4 (5): e5652.
15. Wang K., Baldassano R., Zhang H. et al.Comparative genetic analysis of inflammatory bowel disease and type 1diabetes implicates multiple loci with opposite effects. Hum. Mol. Genet. 2010; 19 (10): 2059-2067.
16. Casas J. P., Hingorani A. D., Bautista L. E., Sharma P.Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch. Neurol. 2004; 61 (11): 1652—1661.
17. Wakahara S., Konoshita T., Mizuno S. et al.Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio. Endocrinology 2007; 148 (5): 2453—2457.
18. Payne J. R., Dhamrait S. S., Gohlke P. et al.The impact of ACE genotype on serum ACE activity in a black South African male population. Ann. Hum. Genet. 2007; 71 (Pt 1): 1—7.
19. Han T. Y., Li Z. L., Ye H. M.Relationship of the disease severity with ACE gene polymorphism and serum ACE activity in preterm infants. Zhongguo Dang Dai Er Ke Za Zhi 2008; 10 (6): 693—696.
20. Godschalk R. W., OstertagJ. U., Zandsteeg A. M.Impact of GSTM1 on aromatic-DNA adducts and P53 accumulation in human skin and lymphocytes. Pharmacogenetics 2001; 11 (6): 537—543.
21. Habdous M., Herbeth B., Haddy N. et al.Smoking, genetic polymorphisms of glutathione S-transferases and biological indices of inflammation and cellular adhesion in the STANISLAS study. EXCLI J. 2004; 3: 58—67.
22. Haataja R., Marttila R., Uimari P. et al.Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test. Hum. Genet. 2001; 109 (3): 351—355.
23. Makri V., Hospes B., Stoll-Becker S. et al.Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome? Eur. J. Pediatr. 2002; 161 (11): 604—608.
24. van Sonderen L., Halsema E. F., Spiering E. J., KoppeJ. G.Genetic influences in respiratory distress syndrome: a twin study. Semin. Perinatol. 2002; 26 (6): 447—449.
25. Marttila R., Haataja R., Ramet M. et al.Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. Hum. Genet. 2003; 112 (1): 18—23.
26. Floras J.Sleep apnea in heart failure: implications of sympathetic nervous system activation for disease progression and treatment. Curr. Heart Fail Rep. 2005; 2 (4): 212—217.
27. Аульченко Ю. С., Аксенович Т. И.Методические подходы и стратегии картирования генов, контролирующих комплексные признаки человека. Информ. вестн. ВОГиС 2006; 10 (1): 189—202.
28. Богданова Р. З., Фатыхова А. И., Данилко К. В. и соавт.Генетические маркеры дыхательных расстройств у новорожденных. Вопросы практич. педиатрии 2008; 3 (6): 12—16.
29. de Mesa R. L., Sierrasesumaga L., de Cerain A. L. et al.Pediatric meningosarcoma: clinical evolution and genetic instability. Pediatr. Neurol. 2005; 32 (5): 352—354.
Review
For citations:
Smelaya T.V., Salnikova L.Ye., Moroz V.V., Golubev A.M., Zarzhetsky Yu.V., Rubanovich A.V. Genetic Polymorphism and the Rate of Development of Complications in Pneumonia of Varying Genesis . General Reanimatology. 2011;7(2):10. (In Russ.) https://doi.org/10.15360/1813-9779-2011-2-10
Views:
1783
Email this article 